Diagnosis of tuberculosis infection in patients awaiting liver transplantation.


:This study examined the performance of a tuberculosis (TB)-specific enzyme-linked immunospot assay in 48 patients awaiting liver transplantation. They were tested with T-SPOT.TB, tuberculin skin test (TST), and lymphocyte transformation test (LTT) using tuberculin as a stimulus. A questionnaire was used to gain information on TB exposure. Four patients were defined as positive by T-SPOT.TB, 6 by TST, and 28 by LTT. The patients displaying positive results to T-SPOT.TB were also positive in the TST and LTT. We considered them to have latent TB because they were repeatedly (two or three times) positive to the T-SPOT.TB and reported TB exposure. Active TB was excluded by negative multislice computed tomography, negative culture, and absence of symptoms. In 1 patient, T-cell reactivity toward TB peptides was lost 1 and 2 months posttransplantation. Another patient, however, tested 8 and 13 months posttransplantation, displayed measurable cellular TB immune responses. This finding suggests that the measurement of cellular TB immune responses shortly after transplantation may fail. If possible, patients with end-stage liver disease should be screened for TB prior to transplantation. Our data are the first evidence that T-SPOT.TB may be useful to diagnose latent TB in patients awaiting liver transplantation.


Hum Immunol


Human immunology


Lindemann M,Dioury Y,Beckebaum S,Cicinnati VR,Gerken G,Broelsch CE,Wrighton-Smith P,Grosse-Wilde H




Has Abstract


2009-01-01 00:00:00














  • Vitamin D receptor upregulation in alloreactive human T cells.

    abstract::Vitamin D deficiency is adversely associated with diseases characterized by inflammation. The combination of the high incidence of vitamin D deficiency in patients undergoing allogeneic stem cell transplants (SCT) and the potential role of vitamin D deficiency in influencing graft-versus-host disease led us to further...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Joseph RW,Bayraktar UD,Kim TK,St John LS,Popat U,Khalili J,Molldrem JJ,Wieder ED,Komanduri KV

    更新日期:2012-07-01 00:00:00

  • Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus.

    abstract::The aim of this study was to test whether the functional variant rs2076530 of the BTNL2 gene confers susceptibility to the autoimmune diseases type 1 diabetes (T1D), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Our study populations consisted of 326 patients with T1D and 351 healthy subjects, 808...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Orozco G,Eerligh P,Sánchez E,Zhernakova S,Roep BO,González-Gay MA,López-Nevot MA,Callejas JL,Hidalgo C,Pascual-Salcedo D,Balsa A,González-Escribano MF,Koeleman BP,Martín J

    更新日期:2005-12-01 00:00:00

  • Microsatellite mapping of a susceptible locus within the HLA region for Behçet's disease using Jordanian patients.

    abstract::Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Mizuki N,Yabuki K,Ota M,Verity D,Katsuyama Y,Ando H,Onari K,Goto K,Imagawa Y,Mandanat W,Fayyad F,Stanford M,Ohno S,Inoko H

    更新日期:2001-02-01 00:00:00

  • Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.

    abstract::Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Tassiulas I,Park-Min KH,Hu Y,Kellerman L,Mevorach D,Ivashkiv LB

    更新日期:2007-03-01 00:00:00

  • TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

    abstract:INTRODUCTION:Tyrosine kinase 2 gene (TYK2) is part of the janus kinase (JAK) that binds to the type I interferon-α receptor (IFNAR) on the cell surface of IFN-producing cells, and have crucial importance in the etiology of autoimmune and inflammatory diseases. Many polymorphisms of the TYK2 gene have been identified, a...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Peluso C,Christofolini DM,Goldman CS,Mafra FA,Cavalcanti V,Barbosa CP,Bianco B

    更新日期:2013-01-01 00:00:00

  • 4-Locus high-resolution HLA allele and haplotype frequencies in admixed population from Nicaragua.

    abstract::A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Arrieta-Bolaños E,Madrigal-Sánchez JJ,Stein JE,Moreira-Espinoza MJ,Paredes-Carias E,Vanegas-Padilla Y,Salazar-Sánchez L,Madrigal JA,Marsh SGE,Shaw BE

    更新日期:2019-07-01 00:00:00

  • Increased RUNX1 expression in patients with immune thrombocytopenia.

    abstract::Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th17 and associated IL-17 were involved in the pathogenesis of ITP. Runt-related transcription factor 1 (RUNX1), a member of the runt domain-containing family of transcription factors, is required ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Zhong X,Wu Y,Liu Y,Zhu F,Li X,Li D,Li Z,Zeng L,Qiao J,Chen X,Xu K

    更新日期:2016-08-01 00:00:00

  • Rapid evaluation of soluble HLA-G levels in supernatants of in vitro fertilized embryos.

    abstract::Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Rebmann V,Switala M,Eue I,Schwahn E,Merzenich M,Grosse-Wilde H

    更新日期:2007-04-01 00:00:00

  • High-resolution characterization of allelic and haplotypic HLA frequency distribution in a Spanish population using high-throughput next-generation sequencing.

    abstract::Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obta...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Montero-Martín G,Mallempati KC,Gangavarapu S,Sánchez-Gordo F,Herrero-Mata MJ,Balas A,Vicario JL,Sánchez-García F,González-Escribano MF,Muro M,Moya-Quiles MR,González-Fernández R,Ocejo-Vinyals JG,Marín L,Creary LE,Osoegawa K

    更新日期:2019-07-01 00:00:00

  • Impaired circulating CD56dim NK cells are associated with decompensation of HBV-related cirrhosis.

    abstract::NK cells play an important role in immune regulation and defense of infection, but their characteristics in patients with decompensated cirrhosis and their relationship with liver function remain unclear. We studied the functional properties of NK cells (including CD56dim NK and CD56bright NK cells) in patients with H...

    journal_title:Human immunology

    pub_type: 临床试验,杂志文章


    authors: Jiang Y,Chen Y,Chen L,Yao W,Guan J,Liu X,Wei X,Lin X

    更新日期:2020-01-01 00:00:00

  • MHC class I and class II phenotype, gene, and haplotype frequencies in Greeks using molecular typing data.

    abstract::In the present study, DNA typing for HLA-A, C, B, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 was performed for 246 healthy, unrelated Greek volunteers of 20-59 years of age. Phenotype, genotype frequencies, Hardy-Weinberg equilibrium fit, and 3-locus haplotype frequencies for HLA-A, C, B, HLA-A, B, DRB1, HLA-DRB1, D...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Papassavas EC,Spyropoulou-Vlachou M,Papassavas AC,Schipper RF,Doxiadis IN,Stavropoulos-Giokas C

    更新日期:2000-06-01 00:00:00

  • Genetic diversity of HLA system in two populations from Yucatán, Mexico: Mérida and rural Yucatán.

    abstract::We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haploty...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Lara-Riegos J,Barquera R,Castillo-Chávez OD,Medina-Escobedo CE,Hernández-Zaragoza DI,Arrieta-Bolaños E,Clayton S,Ponnandai-Shanmugavel KS,Bravo-Acevedo A,Zúñiga J,Yunis EJ,Bekker-Méndez C,Granados J

    更新日期:2020-09-01 00:00:00

  • MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ.

    abstract::To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICA5 was significantly increased in the T1D patient grou...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Van Autreve JE,Koeleman BP,Quartier E,Aminkeng F,Weets I,Gorus FK,Van der Auwera BJ,Belgian Diabetes Registry.

    更新日期:2006-01-01 00:00:00

  • Different HLA antigen associations for the functionally active and inactive products of the complement C4F1 allele.

    abstract::The genetic polymorphism of the fourth component of human complement, C4, was studied in 945 unrelated Caucasian individuals. A third allele of the C4F (Rodgers) locus, termed C4F1 was demonstrated. This allele is characterized using immunofixation electrophoresis, by the presence of an additional fast-moving anodal b...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: O'Neill GJ,Miniter P,Pollack MS,Dupont B

    更新日期:1980-07-01 00:00:00

  • Anti-HLA antibodies interfere in the detection of soluble HLA class I molecules.

    abstract::Heart transplant rejection is routinely defined by histological evaluation of endomyocardial biopsies (EMB). As elevated levels of donor derived sHLA (dsHLA) can be detected in the serum of transplanted patients just before or during rejection, quantification of donor specific soluble counterparts of HLA Class I (sHLA...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Koelman CA,Ensink W,Mulder A,Tanke J,Doxiadis II,Claas FH

    更新日期:1999-05-01 00:00:00

  • Identification of endothelial cell surface antigens encoded by genes other than HLA. A combined immunoprecipitation and proteomic approach for the identification of antigens recognized by antibodies against endothelial cells in transplant recipients.

    abstract::It has been known for some time that transplant recipients may have antibodies to endothelial cells which are not detected on lymphocytes. However, little progress has been made in the analysis of these endothelial antigens. In the present experiments we have attempted to characterize endothelial cell surface antigens...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Qin Z,Zou Y,Lavingia B,Stastny P

    更新日期:2013-11-01 00:00:00

  • Natural killer cells in patients with polycythemia vera.

    abstract::Natural killer cells (NK) are pivotal cells of innate immunity. They are potent antileukemic cytotoxic effectors. A defect in their cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma and myelodysplastic syndromes. This defect is at least partially linked...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Sanchez C,Baier C,Colle JG,Chelbi R,Rihet P,Le Treut T,Imbert J,Sébahoun G,Venton G,Costello RT

    更新日期:2015-09-01 00:00:00

  • Ancestry markers from the human chromosome 6: Alu repeats from the MHC in autochthonous Basques.

    abstract::Polymorphic Alu insertions from the MHC class I region were analyzed in 215 autochthonous Basques from Guipuzcoa and Navarre provinces, with the aim of contributing new MHC Alu data in European ancestry populations. We also seek to assess both the genetic position of native Basques among worldwide samples and the effi...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: García-Obregón S,Alfonso-Sánchez MA,Pérez-Miranda AM,Gómez-Pérez L,de Parcorbo MM,Peña JA

    更新日期:2012-07-01 00:00:00

  • Genetic polymorphisms of interleukin-6 modulate fibrosis progression in mild chronic hepatitis C.

    abstract::Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Falleti E,Fabris C,Vandelli C,Colletta C,Cussigh A,Smirne C,Fontanini E,Cmet S,Minisini R,Bitetto D,Toniutto P,Pirisi M

    更新日期:2010-10-01 00:00:00

  • Soluble HLA-G molecules are increased in lymphoproliferative disorders.

    abstract::The immunomodulatory properties of soluble human leukocyte antigen G (sHLA-G) explain its potential interest in malignancies. HLA-G frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. In this article, we will demonstrate that the plasmatic level of soluble HLA-G was significant...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Sebti Y,Le Friec G,Pangault C,Gros F,Drénou B,Guilloux V,Bernard M,Lamy T,Fauchet R,Amiot L

    更新日期:2003-11-01 00:00:00

  • Structural aspects of HLA class I epitopes reacting with human monoclonal antibodies in Ig-binding, C1q-binding and lymphocytotoxicity assays.

    abstract::This study addresses the reactivity patterns of human cytotoxic HLA class I epitope-specific monoclonal antibodies in Ig-binding and complement component C1q-binding Luminex assays in comparison with complement-dependent lymphocytotoxicity data reported at the 13th International HLA Workshop. Some monoclonal antibodie...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Duquesnoy RJ,Marrari M,Jelenik L,Zeevi A,Claas FH,Mulder A

    更新日期:2013-10-01 00:00:00

  • Characterization of an expressible nonclassical class I HLA gene.

    abstract::Screening of a human cosmid library representing genomic DNA from an individual homozygous for the HLA-DR2 B7 A2 haplotype yielded 109 class I HLA-specific clones. One cosmid clone, Ice 6.23, had a full-length nonclassical class I gene within a 5.4-kb HindIII fragment. The Ice 6.23-5.4H gene was cloned into the unique...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Pook MA,Woodcock V,Tassabehji M,Campbell RD,Summers CW,Taylor M,Strachan T

    更新日期:1991-10-01 00:00:00

  • Narcolepsy without unique MHC class II antigen association: studies in the canine model.

    abstract::Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Dean RR,Kilduff TS,Dement WC,Grumet FC

    更新日期:1989-05-01 00:00:00

  • Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain.

    abstract::Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Vidales MC,Zubillaga P,Zubillaga I,Alfonso-Sánchez MA

    更新日期:2004-04-01 00:00:00

  • Interaction of KIR genes and G1M immunoglobulin allotypes confer susceptibility to type 2 diabetes in Puerto Rican Americans.

    abstract::The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Zuniga J,Romero V,Azocar J,Stern JN,Clavijo O,Almeciga I,Encinales L,Avendano A,Fridkis-Hareli M,Pandey JP,Yunis EJ

    更新日期:2006-11-01 00:00:00

  • DNA sequence analysis of the HLA-DRw12 allele.

    abstract::The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Navarrete C,Seki T,Miranda A,Winchester R,Gregersen PK

    更新日期:1989-05-01 00:00:00

  • TCRBV CDR3 diversity of CD4+ and CD8+ T-lymphocytes in HIV-infected individuals.

    abstract::TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Raaphorst FM,Schelonka RL,Rusnak J,Infante AJ,Teale JM

    更新日期:2002-01-01 00:00:00

  • Transnational validation of the Australian algorithm for virtual crossmatch allocation in kidney paired donation.

    abstract::An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Böhmig GA,Fidler S,Christiansen FT,Fischer G,Ferrari P

    更新日期:2013-05-01 00:00:00

  • Isoforms of human leukocyte antigen-G and their inhibitory receptors in human kidney allograft acceptance.

    abstract::Novel therapeutic strategies such as the modulation of dendritic cell and T-cell function have exhibited great potential in clinical transplantation. Human leukocyte antigen (HLA)-G is a molecule that plays a significant role in establishing complex mechanisms to protect semiallogeneic fetuses from rejection by the ma...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Wu J,Zhang W,Hernandez-Lopez P,Fabelo E,Parikh M,Mulloy LL,Horuzsko A

    更新日期:2009-12-01 00:00:00

  • Human melanoma cell secreting human leukocyte antigen-G5 inhibit natural killer cell cytotoxicity by impairing lytic granules polarization toward target cell.

    abstract::Human leukocyte antigen-G (HLA-G) is a nonclassical tolerogenic molecule that can be expressed either as membrane bound (HLA-G1) or secreted (HLA-G5) isoforms. Upregulation of HLA-G1 or HLA-G5 expression by tumor cells constitutes an efficient way to escape from antitumoral immune responses. The inhibitory role of HLA...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Lesport E,Baudhuin J,LeMaoult J,Sousa S,Doliger C,Carosella ED,Favier B

    更新日期:2009-12-01 00:00:00