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HLA-DRw52a is involved in alloimmunization against PL-A1 antigen.

Abstract：

:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction fragment length polymorphism analysis had the DRw52a specificity at the DRB3 locus whatever their HLA-DRB1 gene product. This finding strongly suggests that the DRB3 chain is directly involved in the presentation of the PL-A1 antigen to the specific T cell. In addition, the similarities between DR3 and DRw52 structures due to a hypothetical gene conversion event should be considered in order to understand the high frequency of DR3 among the DRw52a-responding women. Alternatively, the high frequency of DR3 among the DRw52-responding mothers might be due to the high responder status associated with the former specificity.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

doi

10.1016/0198-8859(90)90104-w

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

73-9

issue

2

eissn

0198-8859

issn

1879-1166

pii

0198-8859(90)90104-W

journal_volume

27

pub_type

杂志文章

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