Abstract:
:Previous studies indicate the distribution of major histocompatibility complex class I chain-related genes A (MICA) and B (MICB) alleles and haplotypes varies widely between different ethnic populations and geographic areas. It is meaningful to investigate allelic frequencies and establish a genetic database. In this study, we firstly reported the polymorphic variation of MICA/B in 187 healthy, unrelated Tujia individuals in Zhangjiajie region, China. Using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (PCR-SBT), we identified eight MICA-sequence alleles, four MICA-short tandem repeat variants, and 13 MICB variants, of which MICA(∗)008:04 (29.41%), MICA(∗)A5 (29.68%), MICA(∗)A5.1 (29.68%) and MICB(∗)005:02 (39.57%) were the most frequent. Linkage disequilibrium analysis further revealed MICB(∗)005:02-MICA(∗)019 (13.10%) and MICB(∗)002-MICA(∗)008:04 (9.89%) as the most common two-locus haplotypes. Data comparison by neighbor-joining dendrograms and principal component analysis to verify allelic frequencies in other Chinese and Asia ethnic groups showed that the Zhangjiajie Tujias were genetically closer to the Guangdong Han population, based on MICA loci variability. Our results provide new information about the MICA/B gene polymorphism in Chinese Tujia population, which will form the basis for future studies on the potential role of MICA/B in allogeneic organ transplantation and disease susceptibility in related ethnic groups.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Wang YJ,Zhang NJ,Chen E,Chen CJ,Bu YH,Yu Pdoi
10.1016/j.humimm.2016.03.005subject
Has Abstractpub_date
2016-05-01 00:00:00pages
411-7issue
5eissn
0198-8859issn
1879-1166pii
S0198-8859(16)30028-3journal_volume
77pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::DNA sequences that distinguish the subsets of HLA-DR4 are also found on several other alleles. This makes typing of heterozygotes with oligonucleotide probes quite impractical. We have therefore developed a procedure in which, in a first step, DNA of the genes to be analyzed is amplified selectively, using group-speci...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90094-6
更新日期:1990-01-01 00:00:00
abstract::The 2',5'-oligoadenylate synthetase 1 (OAS1) is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection. A single nucleotide polymorphism (SNP), rs10774671, presumably responsible for alternate splicing of this gene, has frequently been associated with...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.11.011
更新日期:2013-03-01 00:00:00
abstract::FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing self-reactivity. With the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding thei...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2009.02.007
更新日期:2009-05-01 00:00:00
abstract::The tumor necrosis factor (TNF) and TNF receptor (TNF-TNFR) superfamily plays crucial roles in immune regulation and host immune responses. The superfamily has been also associated with many immune-mediated diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and diabetes. In order to investigate...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.04.005
更新日期:2004-07-01 00:00:00
abstract::Serological identification of a new HLA-Bw16 subtype, B39B, was made by the analysis of reaction patterns of many alloantisera and one monoclonal antibody. The B39B pattern of reactivity was shown to be distinct from HLA-Bw38, Bw39, and 8w57. Cytotoxicity testing before and after absorption suggests that the B39B spec...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90059-x
更新日期:1985-09-01 00:00:00
abstract::Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.12.008
更新日期:2007-03-01 00:00:00
abstract::Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on human T cells. We found that soluble CD52 inhibited T cell signalling by ligating Siglec-10, but the presence of Siglec-10 on human T cells has been questioned. To address this concern, we ex...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2020.01.009
更新日期:2020-01-01 00:00:00
abstract::CD4+ T cells were cultured from posttransplant cardiac biopsies placed on irradiated feeder cells of autologous cloned donor major histocompatibility complex class II-specific T-cell lines cultured and grown from previous biopsies. Fourteen of the CD4+ T-cell cultures were expanded and cloned using the same feeder cel...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90011-d
更新日期:1990-06-01 00:00:00
abstract::The goal of this study was to evaluate the influence of KIR-HLA genotypes on the outcome of patients undergoing treatment for haematological malignancies by non-T-depleted lymphocyte haematopoietic stem cell transplantation (HSCT) from HLA-matched sibling donors. The prospective study was conducted at the Center of He...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.003
更新日期:2016-10-01 00:00:00
abstract::One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(99)00169-x
更新日期:2000-01-01 00:00:00
abstract::Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.12.002
更新日期:2017-02-01 00:00:00
abstract::Perforin (PRF1) gene mutations have been associated with Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2). Substitution p.A91V (c.272C>T) in exon 2 was first described as a neutral polymorphism. Nonetheless, recent clinical evidence and functional assays, suggest a potential pathogenic role for p.A91V, especi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.10.011
更新日期:2013-01-01 00:00:00
abstract::TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00361-5
更新日期:2002-01-01 00:00:00
abstract::TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90183-2
更新日期:1993-07-01 00:00:00
abstract::Detection and avoidance of donor-reactive antibodies in the sera of potential organ transplant recipients is key to a successful transplant outcome. Techniques of antibody detection that use flow cytometry are more sensitive than those that rely upon a visual determination of cytotoxicity. However, as conventionally p...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90016-g
更新日期:1992-10-01 00:00:00
abstract::The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.04.004
更新日期:2016-11-01 00:00:00
abstract::Mannose-binding lectin (MBL) role in the carriage of oropharyngeal bacteria is not known. We investigated the association of smoking, MBL2 polymorphisms, and MBL concentrations with oropharyngeal carriage of respiratory bacteria in young men. Oropharyngeal specimens, MBL concentrations, and MBL2 gene polymorphisms wer...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.12.009
更新日期:2010-03-01 00:00:00
abstract::The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.11.005
更新日期:2017-02-01 00:00:00
abstract::It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00128-7
更新日期:2000-03-01 00:00:00
abstract::Ninety healthy and unrelated volunteers were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIRs) in a Chilean (Talca) population. KIR typing was resolved by PCR-single specific primer (SSP), and their gene frequencies were calculated by direct counting of the number of p...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.06.007
更新日期:2018-09-01 00:00:00
abstract::The class II MHC gene DPA is inducible by interferon-gamma (IFN-gamma), whereas the DQB gene is not inducible in most cell types. To investigate the DNA region specifically responsible for inducibility or its lack that may be required (in addition to the elements required for constitutive expression of class II genes)...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90100-2
更新日期:1992-11-01 00:00:00
abstract::This review discusses the current understanding of biomarkers of immune quiescence based on reviews of published literature in kidney transplant operational tolerance and mechanistic studies based on a better characterization of the stable, well-functioning renal allograft. ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.016
更新日期:2018-05-01 00:00:00
abstract::Polymorphic Alu insertions from the MHC class I region were analyzed in 215 autochthonous Basques from Guipuzcoa and Navarre provinces, with the aim of contributing new MHC Alu data in European ancestry populations. We also seek to assess both the genetic position of native Basques among worldwide samples and the effi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.04.010
更新日期:2012-07-01 00:00:00
abstract::The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)00152-g
更新日期:1995-07-01 00:00:00
abstract::Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.011
更新日期:2016-06-01 00:00:00
abstract::The aim of this study was to investigate the possible association between the inducible nitric oxide synthase (NOS2) gene promoter polymorphism, CCTTTn microsatellite, with celiac disease susceptibility. We carried out a familial study in which 53 Spanish families were genotyped by a polymerase chain reaction (PCR)-ba...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00443-3
更新日期:2002-11-01 00:00:00
abstract::The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We ...
journal_title:Human immunology
pub_type: 杂志文章,meta分析
doi:10.1016/j.humimm.2014.09.005
更新日期:2014-12-01 00:00:00
abstract::HLA-G molecules seem to have a protective effect for the semi-allogeneic fetus by mother immunosuppression. Also, pregnancy pathologies have been associated to HLA-G(∗)01:05N "null allele". In addition, other general regulatory immune functions have been associated to HLA-G in infections, tumors and autoimmunity. Thus...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.12.013
更新日期:2013-04-01 00:00:00
abstract::To evaluate the role of LMP (low molecular weight protein) genes as susceptibility markers for spondyloarthritis (SpA), LMP gene polymorphisms were analyzed in 223 Mexican patients with SpA (81 undifferentiated SpA [U-SpA], 117 with ankylosing spondylitis [AS], 25 with reactive arthritis) and in 139 ethnically matched...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.09.007
更新日期:2004-12-01 00:00:00
abstract::T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90060-0
更新日期:1984-12-01 00:00:00