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Cytomegalovirus (CMV)-specific cellular immune responses.

Abstract：

:A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of the current strategies to identify CMV-specific T cells are centered on the assessment of the functions of memory T cells including their ability to mediate effector function, to proliferate or to secrete cytokines following antigen-specific stimulation. The investigation of these functions has allowed the characterization of the CMV-specific T-cell responses that are present during different phases of the infection. Furthermore, it has also been shown that the combination of virus-specific CD4 and CD8 T-cell responses are critical components of the immune response in the control of virus replication.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Harari A,Zimmerli SC,Pantaleo G

doi

10.1016/j.humimm.2004.02.012

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

500-6

issue

5

eissn

0198-8859

issn

1879-1166

pii

S0198885904000485

journal_volume

65

pub_type

杂志文章,评审

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