Infection with a virus generates a polyclonal immune response with broad alloreactive potential.

abstract：:The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...

journal_title：Human immunology

authors： Prins JR,van der Hoorn MLP,Keijser R,Ris-Stalpers C,van Beelen E,Afink GB,Claas FHJ,van der Post JAM,Scherjon SA

更新日期：2016-01-01 00:00:00

abstract：:Better outcome for hematopoietic stem cell transplantation (HSCT) requires optimal matching between donor and recipient at the HLA-A, -B, -C, and -DRB1 loci. This study estimates the likelihood of identifying HLA matched donors in Hong Kong. 7595 volunteer unrelated Chinese donors at the Hong Kong Bone Marrow Donor Re...

journal_title：Human immunology

authors： Kwok J,Guo M,Yang W,Ip P,Chan GCF,Ho J,Lee CK,Middleton D,Lu L

更新日期：2017-10-01 00:00:00

abstract：:The contributions of individual amino acids in the polymorphic beta chain and the conserved alpha chain of HLA-DR1 to influenza HA-specific DR1-restricted and anti-DR1 allospecific T-cell recognition were analyzed. The genes encoding HLA-DR1 were subjected to site-directed mutagenesis in order to introduce single amin...

journal_title：Human immunology

authors： Tuosto L,Karr RW,Fu XT,Olson RR,Cundari E,Piccolella E,Lechler R,Lombardi G

更新日期：1994-08-01 00:00:00

abstract：:The genetic polymorphism of the fourth component of human complement, C4, was studied in 945 unrelated Caucasian individuals. A third allele of the C4F (Rodgers) locus, termed C4F1 was demonstrated. This allele is characterized using immunofixation electrophoresis, by the presence of an additional fast-moving anodal b...

journal_title：Human immunology

authors： O'Neill GJ,Miniter P,Pollack MS,Dupont B

更新日期：1980-07-01 00:00:00

abstract：:The aim of this study was to determine the prognostic significance of soluble human leukocyte antigen (HLA) class I (sHLA-I) and HLA-G molecules in lung cancer patients. A total of 23 small-cell lung cancer (SCLC) and 114 non-small-cell lung cancer (NSCLC) patients, including 55 adenocarcinoma, 46 squamous cell carcin...

journal_title：Human immunology

authors： Schütt P,Schütt B,Switala M,Bauer S,Stamatis G,Opalka B,Eberhardt W,Schuler M,Horn PA,Rebmann V

更新日期：2010-05-01 00:00:00

abstract：:Using a large battery of Bw16, w38, and w39 antisera, a new variant of Bw16 has been identified in four unrelated Mexican-American families. The serologic pattern obtained is distinct from that for Bw38, Bw39, and 8W57 antigens. Absorption studies confirm the existence of this new Bw16 subtype which we term ST-16. ST-...

journal_title：Human immunology

authors： Ness DB,Watson AK,Grumet FC

更新日期：1982-02-01 00:00:00

abstract：:Indirect immunofluorescence staining with monoclonal antibodies has shown a differential distribution of HLA-DR, DQ, and DP antigens in normal tissues of nonlymphoid origin. The distribution of HLA-DP antigens is similar to that of HLA-DR antigens, while that of HLA-DQ antigens is more restricted. Malignant transforma...

journal_title：Human immunology

authors： Natali P,Bigotti A,Cavalieri R,Nicotra MR,Tecce R,Manfredi D,Chen YX,Nadler LM,Ferrone S

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...

journal_title：Human immunology

authors： Jalalonmuhali M,Caroll R,Deayton S,Emery T,Humphreys I,Lim SJ,Lim SK,Coates T

更新日期：2020-12-01 00:00:00

abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...

journal_title：Human immunology

authors： Jackson DG,Capra JD

更新日期：1995-05-01 00:00:00

abstract：:The aim of this study was to investigate the possible association between the inducible nitric oxide synthase (NOS2) gene promoter polymorphism, CCTTTn microsatellite, with celiac disease susceptibility. We carried out a familial study in which 53 Spanish families were genotyped by a polymerase chain reaction (PCR)-ba...

journal_title：Human immunology

authors： Rueda B,López-Nevot MA,Pascual M,Ortega E,Maldonado J,López ML,Koeleman BP,Martín J

更新日期：2002-11-01 00:00:00

abstract：:Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our resul...

journal_title：Human immunology

authors： Reed AM,Pachman L,Ober C

更新日期：1991-12-01 00:00:00

abstract：:In vitro primary sensitization of human peripheral blood T-cells to hemocyanins was detected during a 12-14 day culture period with antigen (KLH or HCH)-pulsed macrophages. Primed T-cells proliferate in secondary culture (2-3 days) when restimulated with antigen presented by macrophages. The kinetics of primary sensit...

journal_title：Human immunology

authors： Ford D,Hamblin A,Dumonde D,Burger D

更新日期：1982-06-01 00:00:00

abstract：:Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...

journal_title：Human immunology

authors： Mizuki N,Yabuki K,Ota M,Verity D,Katsuyama Y,Ando H,Onari K,Goto K,Imagawa Y,Mandanat W,Fayyad F,Stanford M,Ohno S,Inoko H

更新日期：2001-02-01 00:00:00

abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

journal_title：Human immunology

authors： Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

更新日期：1999-01-01 00:00:00

abstract：:Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating t...

journal_title：Human immunology

authors： Cifuentes RA,Rojas-Villarraga A,Anaya JM

更新日期：2011-07-01 00:00:00

abstract：:In order to characterize directly the T-cell repertoire utilized in human renal allograft rejection, we analyzed 20 long-term T-cell lines established from lymphocytic infiltrates present in renal tissue obtained by needle biopsy from transplant patients with rejection indications. All cell lines are strongly cytotoxi...

journal_title：Human immunology

authors： Miceli MC,Barry TS,Finn OJ

更新日期：1988-07-01 00:00:00

abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

journal_title：Human immunology

authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

更新日期：1990-02-01 00:00:00

abstract：:The relevance of pre-existing HLA-antibodies (HLA-Ab) in liver transplantation (LTx) is controversial. While livers are allocated without HLA match or preoperative crossmatch testing, several studies point to an impact of donor specific antibodies (DSA) for acute rejection, bile duct complications or even graft loss. ...

journal_title：Human immunology

authors： Koch M,Marget M,Sterneck M,Fischer L,Thude H,Nashan B

更新日期：2018-07-01 00:00:00

abstract：:Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...

journal_title：Human immunology

authors： Perry RT,Nyaku MK,Aissani B,Shrestha S

更新日期：2014-08-01 00:00:00

abstract：:Dendritic cells play an important role in the initiation of immune reactions. Due to their high capacity to prime T-cell responses, the activation of dendritic cells must be tightly controlled. Because Interleukin-1β (IL-1β) is a key player in autoinflammatory diseases, we compared the ability of IL-1β to activate hum...

journal_title：Human immunology

authors： Michelini S,Sarajlic M,Duschl A,Horejs-Hoeck J

更新日期：2018-08-01 00:00:00

abstract：:A novel cell surface molecule, DN4, defined by an mAb raised against human thymic epithelial cells, showed a specificity for epithelial cells of the thymic cortex. This antigen was not expressed at detectable levels on any other types of tissues in the human body except for the thymus and bone marrow. Immunohistochemi...

journal_title：Human immunology

authors： Chung DH,Choi EY,Lee GK,Bae YM,Hahn JH,Kim SS,Song HG,Park WS,Ahn HS,Park SH

更新日期：1996-02-01 00:00:00

abstract：:To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3-/(CD56+ or CD16+) rat...

journal_title：Human immunology

authors： Chen CK,Huang SC,Chen CL,Yen MR,Hsu HC,Ho HN

更新日期：1995-03-01 00:00:00

abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...

journal_title：Human immunology

authors： Grifoni A,Weiskopf D,Lindestam Arlehamn CS,Angelo M,Leary S,Sidney J,Frazier A,Phillips E,Mallal S,Mack SJ,Tippalagama R,Goonewardana S,Premawansa S,Premawansa G,Wijewickrama A,De Silva AD,Sette A

更新日期：2018-02-01 00:00:00

abstract：:Monoclonal antibodies have revealed complexity within the human leukocyte antigen class II antigens. We have studied epitopes present on a DR3 homozygous B-lymphoblastoid cell line using five polymorphic monoclonal antibodies produced and characterized in our laboratory. Serological analysis on a panel of B-cell lines...

journal_title：Human immunology

authors： Fuggle SV,Carter C,Watts F,Kirkley J,Morris PJ

更新日期：1987-11-01 00:00:00

abstract：:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...

journal_title：Human immunology

authors： Kitaya K,Yasuo T

更新日期：2010-02-01 00:00:00

abstract：:The Human Leukocyte Antigen-G has immunomodulatory function and its expression has been associated with several diseases. In our study we analyzed HLA-G polymorphisms in order to evaluate their possible association with susceptibility to celiac disease development. A total of 420 celiac patients and 509 controls were ...

journal_title：Human immunology

authors： Catamo E,Zupin L,Segat L,Celsi F,Crovella S

更新日期：2015-01-01 00:00:00

abstract：:Human leukocyte antigen (HLA) antibodies are epitope specific and not antigen specific. This work presents a case of intra-allele (IA) sensitization. A 40-year-old-man underwent transplantion with identical "broad" DR. He was apparently not sensitized to HLA antigens by complement-dependent cytotoxicity (CDC), with on...

journal_title：Human immunology

authors： Muro M,González-Soriano MJ,Salgado G,López R,Boix F,López M,Campillo JA,Martínez P,Botella C,Gimeno L,Minguela A,Alvarez-López MR,Llorente S

更新日期：2010-09-01 00:00:00

abstract：:Using the soft-agar colony assay, we have generated three MT3-associated clones: HJ1, HJ13, and HJ39, from an MLR combination of two unrelated individuals. Another clone, HJ37, appeared to recognize a novel HLA-D determinant. PLT inhibition studies with monoclonal anti-Ia-like antibodies (Mab) were conducted on clones...

journal_title：Human immunology

authors： Zeevi A,Annen K,Scheffel C,Duquesnoy RJ

更新日期：1983-02-01 00:00:00

abstract：:The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analys...

journal_title：Human immunology

authors： Hurley CK,Fernandez-Vina M,Hildebrand WH,Noreen HJ,Trachtenberg E,Williams TM,Baxter-Lowe LA,Begovich AB,Petersdorf E,Selvakumar A,Stastny P,Hegland J,Hartzman RJ,Carston M,Gandham S,Kollman C,Nelson G,Spellman S,Sett

更新日期：2007-01-01 00:00:00

abstract：:Recent studies from this laboratory reported the mapping of the full profile of T-cell allorecognition regions of HLA-DR2 beta subunit. The results indicated the presence of an allodeterminant within DR2 beta regions 141-156. In another study, we have shown that this allodeterminant is one of five regions of structura...

journal_title：Human immunology

authors： Atassi H,Atassi MZ

更新日期：1992-05-01 00:00:00