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Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501.

Abstract：

:Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1 *0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Reed AM,Pachman L,Ober C

doi

10.1016/0198-8859(91)90085-n

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

235-40

issue

4

eissn

0198-8859

issn

1879-1166

pii

0198-8859(91)90085-N

journal_volume

32

pub_type

杂志文章

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