A role for both HLA-F and HLA-G in reproduction and during pregnancy?

abstract：:The loss of melanocytes in vitiligo is mainly attributed to defective autoimmune mechanisms and lately autoinflammatory mediators have become more emphasized. Among these, a number of class II cytokines and their receptors have displayed altered expression patterns in vitiligo. Thus, we selected 30 SNPs from the regio...

journal_title：Human immunology

authors： Traks T,Karelson M,Reimann E,Rätsep R,Silm H,Vasar E,Kõks S,Kingo K

更新日期：2016-05-01 00:00:00

abstract：:Screening of a human cosmid library representing genomic DNA from an individual homozygous for the HLA-DR2 B7 A2 haplotype yielded 109 class I HLA-specific clones. One cosmid clone, Ice 6.23, had a full-length nonclassical class I gene within a 5.4-kb HindIII fragment. The Ice 6.23-5.4H gene was cloned into the unique...

journal_title：Human immunology

authors： Pook MA,Woodcock V,Tassabehji M,Campbell RD,Summers CW,Taylor M,Strachan T

更新日期：1991-10-01 00:00:00

abstract：:To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3-/(CD56+ or CD16+) rat...

journal_title：Human immunology

authors： Chen CK,Huang SC,Chen CL,Yen MR,Hsu HC,Ho HN

更新日期：1995-03-01 00:00:00

abstract：:Natural antigen processing and presentation of antigen is thought to be important for the generation of a broad functional repertoire of antigen-specific T cells. In this study, the T-cell repertoire to an immunodominant human leukocyte antigen A2 (HLA-A2) binding peptide epitope of HER-2/neu, p369-377, was examined i...

journal_title：Human immunology

authors： Knutson KL,Disis ML

更新日期：2002-07-01 00:00:00

abstract：:The polymorphic MICA gene encodes glycoproteins that activate T cells and NK cells through the NKG2D receptor and may costimulate immune functions. We found that MICA was expressed on freshly isolated human fibroblasts and was markedly decreased when fibroblasts were grown to confluency in culture dishes. MICA surface...

journal_title：Human immunology

authors： Zou Y,Mirbaha F,Stastny P

更新日期：2006-03-01 00:00:00

abstract：:There are four DRw8 haplotypes with different DQ alleles in Japanese: DRw8-DQw6 (w1), DRw8-DQw4, DRw8-DQw8(w3), and DRw8-DQw7 (w3). We previously reported the nucleotide sequence of DRB1 gene of DRw8-DQw6(w1) and it was named DRB1*08032. The nucleotide sequences of the other DRw8 DRB1 alleles and their correspondence ...

journal_title：Human immunology

authors： Watanabe Y,Matsushita S,Kohsaka T,Kobayashi N,Nose Y,Tokunaga K,Juji T

更新日期：1992-07-01 00:00:00

abstract：:Graves disease (GD) is an autoimmune thyroid disease and is associated with human leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians. However, the association of HLA with GD is less clear-cut in East Asian populations. We analyzed HLA-DRB1 and -DQB1 associations with GD in 198 Korean patients compared with 200 he...

journal_title：Human immunology

authors： Park MH,Park YJ,Song EY,Park H,Kim TY,Park DJ,Park KS,Cho BY

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Tyrosine kinase 2 gene (TYK2) is part of the janus kinase (JAK) that binds to the type I interferon-α receptor (IFNAR) on the cell surface of IFN-producing cells, and have crucial importance in the etiology of autoimmune and inflammatory diseases. Many polymorphisms of the TYK2 gene have been identified, a...

journal_title：Human immunology

authors： Peluso C,Christofolini DM,Goldman CS,Mafra FA,Cavalcanti V,Barbosa CP,Bianco B

更新日期：2013-01-01 00:00:00

abstract：:Development of tolerance protocols requires assays or biomarkers that distinguish tolerant recipients from non-tolerant ones to be established. In addition, a thorough understanding of the plausible mechanisms associated with clinical transplant tolerance is necessary to take the field forward. Unlike the majority of ...

journal_title：Human immunology

authors： Mathew JM,Ansari MJ,Gallon L,Leventhal JR

更新日期：2018-05-01 00:00:00

abstract：:Previously, most models that sought to explain the misregulation of immune cell function assumed molecular similarities between the disease-causing pathogens and the host's proteins. In recent time several different models have been proposed and in this study, these concepts are compared to a new hypothesis proposing ...

journal_title：Human immunology

authors： Arneth BM

更新日期：2009-09-01 00:00:00

abstract：:A role of CD4(+) cells in the regulation of immune responses has steadily gained renewed recognition. The understanding of these T-regulatory (T-reg) cells in the generation of antitumor cytolytic T lymphocyte (CTL) response is therefore important. It has been shown that immunization with specific peptides, DNA, or tu...

journal_title：Human immunology

authors： Chakraborty NG,Chattopadhyay S,Mehrotra S,Chhabra A,Mukherji B

更新日期：2004-08-01 00:00:00

abstract：:Recent studies have suggested a clinical significance to the detection of anti-major histocompatibility complex class I-related chain A (MICA) antibodies in transplantation. We have developed an eplet-based version of the HLAMatchmaker algorithm to assess the epitope specificity of these antibodies. Molecular viewing ...

journal_title：Human immunology

authors： Duquesnoy RJ,Mostecki J,Hariharan J,Balazs I

更新日期：2008-12-01 00:00:00

abstract：:The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased ...

journal_title：Human immunology

authors： Liwski RS,Greenshields AL,Murphey C,Bray RA,Gebel HM

更新日期：2017-01-01 00:00:00

abstract：:A novel cell surface molecule, DN4, defined by an mAb raised against human thymic epithelial cells, showed a specificity for epithelial cells of the thymic cortex. This antigen was not expressed at detectable levels on any other types of tissues in the human body except for the thymus and bone marrow. Immunohistochemi...

journal_title：Human immunology

authors： Chung DH,Choi EY,Lee GK,Bae YM,Hahn JH,Kim SS,Song HG,Park WS,Ahn HS,Park SH

更新日期：1996-02-01 00:00:00

abstract：:The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...

journal_title：Human immunology

authors： Elliott SR,Macardle PJ,Roberton DM,Zola H

更新日期：1999-11-01 00:00:00

abstract：:We have investigated the distribution of genotypes of a restriction fragment length polymorphism of the T-cell receptor beta-subunit gene in Caucasoid controls and patients with insulin-dependent diabetes mellitus, celiac disease, dermatitis herpetiformis, and idiopathic membranous nephropathy and also in South Indian...

journal_title：Human immunology

authors： Niven MJ,Caffrey C,Moore RH,Sachs JA,Mohan V,Festenstein H,Hoover ML,Hitman GA

更新日期：1990-04-01 00:00:00

abstract：:A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of t...

journal_title：Human immunology

authors： Harari A,Zimmerli SC,Pantaleo G

更新日期：2004-05-01 00:00:00

abstract：:Immunoglobulin idiotypes (Id) of malignant B cells represent highly specific markers which can be used for vaccination. PCR-amplification of immunoglobulin genes enables the rapid production of large amounts of Id vaccines. However, the separate amplification and subsequent recombination of heavy and light chains can ...

journal_title：Human immunology

authors： Terness P,Welschof M,Moldenhauer G,Jung M,Moroder L,Kirchhoff F,Kipriyanov S,Little M,Opelz G

更新日期：1997-08-01 00:00:00

abstract：:We have reviewed the literature on the association of HLA class II with rheumatoid arthritis (RA). Strong linkage disequilibrium among DQB1, DQA1 and DRB1 alleles makes it difficult to evaluate the individual contribution of each locus. Nonetheless, there is a strong case for the role of DQB1*03 and *04 combined with ...

journal_title：Human immunology

authors： Zanelli E,Breedveld FC,de Vries RR

更新日期：2000-12-01 00:00:00

abstract：:Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed antigens. Lysis of cells sensitized with exogenously provided and endo...

journal_title：Human immunology

authors： Sauma SY,Gammon MC,Bednarek MA,Cunningham B,Biddison WE,Hermes JD,Porter G,Tamhankar S,Hawkins JC,Bush BL

更新日期：1993-08-01 00:00:00

abstract：:Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remain...

journal_title：Human immunology

authors： Hefazi M,Hogan WJ,Wakefield LL,Gandhi MJ

更新日期：2018-12-01 00:00:00

abstract：:HLA-G molecules seem to have a protective effect for the semi-allogeneic fetus by mother immunosuppression. Also, pregnancy pathologies have been associated to HLA-G(∗)01:05N "null allele". In addition, other general regulatory immune functions have been associated to HLA-G in infections, tumors and autoimmunity. Thus...

journal_title：Human immunology

authors： Arnaiz-Villena A,Enriquez-de-Salamanca M,Areces C,Alonso-Rubio J,Abd-El-Fatah-Khalil S,Fernandez-Honrado M,Rey D

更新日期：2013-04-01 00:00:00

abstract：:Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...

journal_title：Human immunology

authors： Heinold A,Kuehl B,Brenner-Weiss G,Opelz G,Tran TH

更新日期：2010-05-01 00:00:00

abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

journal_title：Human immunology

authors： Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

更新日期：1999-01-01 00:00:00

abstract：:To evaluate the role of LMP (low molecular weight protein) genes as susceptibility markers for spondyloarthritis (SpA), LMP gene polymorphisms were analyzed in 223 Mexican patients with SpA (81 undifferentiated SpA [U-SpA], 117 with ankylosing spondylitis [AS], 25 with reactive arthritis) and in 139 ethnically matched...

journal_title：Human immunology

authors： Vargas-Alarcón G,Gamboa R,Zuñiga J,Fragoso JM,Hernández-Pacheco G,Londoño J,Pacheco-Tena C,Cardiel MH,Granados J,Burgos-Vargas R

更新日期：2004-12-01 00:00:00

abstract：:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...

journal_title：Human immunology

authors： Gambelunghe G,Brozzetti AL,Ghaderi M,Tortoioli C,Falorni A

更新日期：2006-12-01 00:00:00

abstract：:Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...

journal_title：Human immunology

authors： Venet F,Schilling J,Cazalis MA,Demaret J,Poujol F,Girardot T,Rouget C,Pachot A,Lepape A,Friggeri A,Rimmelé T,Monneret G,Textoris J

更新日期：2017-01-01 00:00:00

abstract：:As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...

journal_title：Human immunology

authors： Verbruggen LA,Versaen H,Rebmann V,Duquet W,De Cock S,Grosse-Wilde H,Demanet C

更新日期：2002-09-01 00:00:00

abstract：:An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with th...

journal_title：Human immunology

authors： Gomez-Casado E,Martinez-Laso J,Vargas-Alarcón G,Varela P,Diaz-Campos N,Alvarez M,Alegre R,Arnaiz-Villena A

更新日期：1997-04-15 00:00:00

abstract：:The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...

journal_title：Human immunology

authors： Rasmussen HB,Kelly MA,Clausen J

更新日期：2001-04-01 00:00:00