当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > In vitro model for the activation of CD4 and CD8 T cell receptors.

In vitro model for the activation of CD4 and CD8 T cell receptors.

Abstract：

:Previously, most models that sought to explain the misregulation of immune cell function assumed molecular similarities between the disease-causing pathogens and the host's proteins. In recent time several different models have been proposed and in this study, these concepts are compared to a new hypothesis proposing another explanation for this immune dysregulation: the possibility that the mislocalization of proteins may be responsible for autoimmune activity. Based on this hypothesis, proteins are recognized as self or non-self depending on where they appear in sufficiently high concentrations. To examine this new idea, the intracellular human proteins beta-actin, GAPDH, and hemoglobin as well as the extracellular human proteins insulin and albumin, were added to human whole blood samples. After an incubation period, the activation of whole-blood T lymphocytes in the samples was measured. The observed activation pattern of the T lymphocytes fit well with the proposed hypothesis. Therefore, these data suggest that protein mislocalization and/or errors within protein trafficking might be important in the development of autoimmune diseases.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Arneth BM

doi

10.1016/j.humimm.2009.05.010

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

670-7

issue

9

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(09)00139-6

journal_volume

70

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Activating KIR2DS5 receptor is a risk for thyroid cancer.

    abstract：:Natural killer (NK) cells are key members of innate immunity against tumor and infection. Killer cell immunoglobulin-like receptor (KIR) genes regulates NK cell function, which varies substantially between individuals in the number and type. Specific KIRs are associated with certain diseases. Herein we investigated if...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.07.325

    authors： Ashouri E,Dabbaghmanesh MH,Rowhanirad S,Bakhshayeshkaram M,Ranjbar Omrani G,Ghaderi A

    更新日期：2012-10-01 00:00:00

  • Expression of human leukocyte antigen-G in systemic lupus erythematosus.

    abstract：:The purpose of this study was to examine the expression of human leukocyte antigen-G (HLA-G) in patients with systemic lupus erythematosus (SLE) and its relation with interleukin-10 (IL-10) production. The study included 50 female SLE patients and 59 healthy female donors. HLA-G expression in peripheral blood and cuta...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.11.001

    authors： Rosado S,Perez-Chacon G,Mellor-Pita S,Sanchez-Vegazo I,Bellas-Menendez C,Citores MJ,Losada-Fernandez I,Martin-Donaire T,Rebolleda N,Perez-Aciego P

    更新日期：2008-01-01 00:00:00

  • Inverse association of peripheral blood CD4(+) invariant natural killer T cells with atopy in human asthma.

    abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.10.011

    authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

    更新日期：2010-02-01 00:00:00

  • IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis.

    abstract：AIMS:We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. PATIENTS AND METHODS:46 IPF patients underwent genotyping, 43 of them had HRCT and 14 patients had a sur...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.07.011

    authors： Vasakova M,Sterclova M,Matej R,Olejar T,Kolesar L,Skibova J,Striz I

    更新日期：2013-10-01 00:00:00

  • β-1,4-galactosyltransferase-I activates proliferation and participates in intercellular contacts of lymphocytes.

    abstract：:Beta-1,4-galactosyltransferase I (β-1,4-GalT-I) mediates several biological mechanisms as a key enzyme in glycobiology, but the role of β-1,4-GalT-I in immune system remains unclear. We conducted experiments to investigate whether β-1,4-GalT-I is participating in the activation of Jurkat T cell and intercellular conta...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2014.08.199

    authors： Sun X,Wu Y,Wang Y,Xue Q,Cheng X,Zhang G,Zhu Y,Wang X

    更新日期：2014-10-01 00:00:00

  • Clonal analysis of HLA-DR and -DQ associated determinants: their contribution to Dw specificities.

    abstract：:In order to investigate the distribution of epitopes recognized by T-cell clones directed against HLA class II products, bulk primed cell populations were generated using cells matched for class I determinants but disparate for class II determinants. Cells were cloned by single cell deposition (FACS IV) or limiting di...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(86)90060-1

    authors： Reinsmoen NL,Bach FH

    更新日期：1986-08-01 00:00:00

  • Soluble HLA-DR levels in serum are associated with therapy and genetic factors in rheumatoid arthritis.

    abstract：:As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(02)00431-7

    authors： Verbruggen LA,Versaen H,Rebmann V,Duquet W,De Cock S,Grosse-Wilde H,Demanet C

    更新日期：2002-09-01 00:00:00

  • Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility.

    abstract：:The C-type lectins DC-SIGN and L-SIGN are important pathogen-recognition receptors of the human innate immune system. Both lectins have been shown to interact with a vast range of infectious agents, including Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. In addition, DC-SIGN and L-SIGN pos...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.10.020

    authors： Barreiro LB,Neyrolles O,Babb CL,van Helden PD,Gicquel B,Hoal EG,Quintana-Murci L

    更新日期：2007-02-01 00:00:00

  • HLA class II-restricted binding of muramyl peptides to B lymphocytes of normal and narcoleptic subjects.

    abstract：:The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90046-r

    authors： Silverman DH,Sayegh MH,Alvarez CE,Johnson TS,Milford EL,Karnovsky ML

    更新日期：1990-03-01 00:00:00

  • Expression of extra class I major histocompatibility antigens on T-cell acute lymphoblastic leukemia (ALL) lymphoblasts.

    abstract：:The presence of extra HLA antigens has been demonstrated, serologically and biochemically, on the surface of lymphoblasts from a patient with acute lymphoblastic leukemia of the T-cell subtype (T-ALL). Family analysis of this patient revealed the presence of the expected antigens, plus an additional HLA antigen (A24) ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(85)90331-3

    authors： Orgad S,Yang SY,Gazit E,Relias V,Zaizov R,Lyson S,Yunis EJ

    更新日期：1985-03-01 00:00:00

  • High-resolution allele frequencies for NGS based HLA-A, B, C, DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry.

    abstract：:Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopo...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2019.12.005

    authors： Nestorowicz K,Bogacz A,Bukowska A,Chraplak M,Czerwiński J,Góralski M,Gronkowski M,Jopek K,Kniżewski Ł,Kolasiński M,Kowalski ML,Nowak J,Sowiński M,Wróblewska-Kabba S,Tymoniuk B,Dudkiewicz M

    更新日期：2020-01-01 00:00:00

  • Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells.

    abstract：:The existence of dendritic cell (DC) subsets is firmly established, but their trafficking properties are still largely unknown. We have indicated that myeloid dendritic cells (M-DCs) and plasmacytoid dendritic cells (P-DCs) isolated from human blood differ widely in the capacity to migrate to chemotactic stimuli. The ...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0198-8859(02)00755-3

    authors： Penna G,Vulcano M,Sozzani S,Adorini L

    更新日期：2002-12-01 00:00:00

  • Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils.

    abstract：:Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.12.002

    authors： Loganathan R,Nazeer M,Goda V,Devaraju P,Ali M,Karunakaran P,Jayaraman M

    更新日期：2017-02-01 00:00:00

  • Ancestry markers from the human chromosome 6: Alu repeats from the MHC in autochthonous Basques.

    abstract：:Polymorphic Alu insertions from the MHC class I region were analyzed in 215 autochthonous Basques from Guipuzcoa and Navarre provinces, with the aim of contributing new MHC Alu data in European ancestry populations. We also seek to assess both the genetic position of native Basques among worldwide samples and the effi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.04.010

    authors： García-Obregón S,Alfonso-Sánchez MA,Pérez-Miranda AM,Gómez-Pérez L,de Parcorbo MM,Peña JA

    更新日期：2012-07-01 00:00:00

  • Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children.

    abstract：:The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00090-7

    authors： Elliott SR,Macardle PJ,Roberton DM,Zola H

    更新日期：1999-11-01 00:00:00

  • Siglec-10 expression is up-regulated in activated human CD4+ T cells.

    abstract：:Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on human T cells. We found that soluble CD52 inhibited T cell signalling by ligating Siglec-10, but the presence of Siglec-10 on human T cells has been questioned. To address this concern, we ex...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.01.009

    authors： Bandala-Sanchez E,Bediaga NG,Naselli G,Neale AM,Harrison LC

    更新日期：2020-01-01 00:00:00

  • Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles.

    abstract：:CD8(+) T-cell responses to three human cytomegalovirus (CMV) pp65 epitopes were studied in panels of healthy seropositive HLA-A*02/HLA-B*07 individuals, and HLA-A*02 donors mismatched for HLA-B*07. The majority of the latter had significant responses to a HLA-A*02-restricted epitope within the CMV pp65 antigen. By con...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(03)00028-4

    authors： Lacey SF,Villacres MC,La Rosa C,Wang Z,Longmate J,Martinez J,Brewer JC,Mekhoubad S,Maas R,Leedom JM,Forman SJ,Zaia JA,Diamond DJ

    更新日期：2003-04-01 00:00:00

  • Gm markers in celiac disease.

    abstract：:The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(83)90065-4

    authors： Carbonara AO,DeMarchi M,van Loghem E,Ansaldi N

    更新日期：1983-02-01 00:00:00

  • HLA-DRw52a is involved in alloimmunization against PL-A1 antigen.

    abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90104-w

    authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

    更新日期：1990-02-01 00:00:00

  • Molecular complexity of HLA-DQw3: the TA10 determinant is located on a subset of DQw3 beta chains.

    abstract：:In attempts to examine the relationships between serologic and structural polymorphisms of HLA-DQ molecules we have analyzed several monoclonal antibodies generated against polymorphic determinants on HLA-DQ molecules. One antibody, SFR20-DQw3, has a serologic reactivity like that of the previously characterized anti-...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(87)90076-0

    authors： Radka SF,Scott RG,Stewart SJ

    更新日期：1987-04-01 00:00:00

  • CTLA-4 polymorphism and clinical outcome post allogeneic hematopoietic stem cell transplantation.

    abstract：:CTLA-4 inhibitory molecule plays an important role in regulating T cell activation. It is considered a crucial element in keeping the immune balance and has been implicated in cancer, autoimmunity and transplantation immunology. Inconsistent observations are reported regarding its association with hematopoietic stem c...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.002

    authors： Mossallam GI,Samra MA

    更新日期：2013-12-01 00:00:00

  • TLR expression, phagocytosis and oxidative burst in healthy and septic newborns in response to Gram-negative and Gram-positive rods.

    abstract：:The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.07.230

    authors： Silveira-Lessa AL,Quinello C,Lima L,Redondo ACC,Ceccon MEJR,Carneiro-Sampaio M,Palmeira P

    更新日期：2016-10-01 00:00:00

  • Streptococcus pyogenes type 5 M protein is an antigen, not a superantigen, for human T cells.

    abstract：:M proteins are coiled-coil dimers expressed on group A streptococcal cell surfaces. They have an important role in host antistreptococcal immunity and in poststreptococcal autoimmune sequelae. Controversy has arisen regarding whether type 5 M proteins are superantigenic for human T cells. To investigate this, we have ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/S0198-8859(97)00028-1

    authors： Degnan B,Taylor J,Hawkes C,O'Shea U,Smith J,Robinson JH,Kehoe MA,Boylston A,Goodacre JA

    更新日期：1997-04-01 00:00:00

  • Real-time PCR using fluorescent resonance emission transfer probes for HLA-B typing.

    abstract：:HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.02.038

    authors： Faner R,Casamitjana N,Coll J,Caro P,Pujol-Borrell R,Palou E,Juan M

    更新日期：2006-04-01 00:00:00

  • T follicular helper cell-mediated IL-21 production suppresses FOXP3 expression of T follicular regulatory-like cells in diffuse large B cell lymphoma patients.

    abstract：:Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25- Tfh subset (CD25-CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could sup...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.05.008

    authors： Ma X,Zha J,He J,Chen L,Huang J,Wu W,Tian P,Qian BH,Yu L,Jiang Y,Xu B

    更新日期：2020-08-01 00:00:00

  • HLA-G regulatory haplotypes and implantation outcome in couples who underwent assisted reproduction treatment.

    abstract：:The role of HLA-G in several clinical conditions related to reproduction has been investigated. Important polymorphisms have been found within the 5'URR and 3'UTR regions of the HLA-G promoter. The aim of the present study was to investigate 16 SNPs in the 5'URR and 14-bp insertion/deletion (ins/del) polymorphism loca...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.06.002

    authors： Costa CH,Gelmini GF,Wowk PF,Mattar SB,Vargas RG,Roxo VM,Schuffner A,Bicalho Mda G

    更新日期：2012-09-01 00:00:00

  • Increased expressions of CD69 and HLA-DR but not of CD25 or CD71 on endometrial T lymphocytes of nonpregnant women.

    abstract：:To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3-/(CD56+ or CD16+) rat...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)00105-y

    authors： Chen CK,Huang SC,Chen CL,Yen MR,Hsu HC,Ho HN

    更新日期：1995-03-01 00:00:00

  • No association of the HLA-DQ alleles with myasthenia gravis in Cuban patients.

    abstract：:Myasthenia gravis (MG) is a neuromuscular disorder characterized by fatigability and weakness of striated muscles. Its association with HLA molecules is well known and varies depending on age, sex and the ethnicity of the patients. A case-control study was performed in 61 Cuban patients and 81 controls using polymeras...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.04.027

    authors： Sylvia T,Samuel M,Luis G,Zuzet M

    更新日期：2013-08-01 00:00:00

  • Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child.

    abstract：:Pregnancy can prime the maternal humoral immune response against paternal human leukocyte antigens (HLA) of the child. Previous studies have reported that formation of antibodies against inherited paternal HLA is associated with the presence of primed cytotoxic T lymphocytes (CTLs) specific for these antigens. Recentl...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(02)00396-8

    authors： van Kampen CA,Versteeg-vd Voort Maarschalk MF,Langerak-Langerak J,Roelen DL,Claas FH

    更新日期：2002-06-01 00:00:00

  • HLA-class I-specific inhibitory receptors in HIV-1 infection.

    abstract：:One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0198-8859(99)00169-x

    authors： De Maria A,Moretta L

    更新日期：2000-01-01 00:00:00