Abstract:
:Development of tolerance protocols requires assays or biomarkers that distinguish tolerant recipients from non-tolerant ones to be established. In addition, a thorough understanding of the plausible mechanisms associated with clinical transplant tolerance is necessary to take the field forward. Unlike the majority of molecular signature analyses utilized by others, the emphasis of this article is on the cellular and functional biomarkers of induced transplant tolerance. Immunity to an organ transplant is very complex, comprised of two broad categories - innate and acquired or adaptive immune responses. Innate immunity can be avoided by eliminating or preventing ischemic injuries to the donor organ and tolerance at the level of adaptive immunity can be induced by infusions of a number of cellular products. Since adaptive immune response consists of inflammatory hypersensitivity, cellular (cytotoxic and helper) and humoral aspects, all these need to be measured, and the recipients who demonstrate donor-specific unresponsiveness in all can be considered tolerant or candidates for immunosuppression minimization and/or withdrawal. The mechanisms by which these agents bring about transplant tolerance include regulation, anergy, exhaustion, senescence and deletion of the recipient immune cells. Another proven mechanism of tolerance is full or mixed donor chimerism. However, it should be cautioned that non-deletional tolerance can be reversed.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Mathew JM,Ansari MJ,Gallon L,Leventhal JRdoi
10.1016/j.humimm.2018.01.009subject
Has Abstractpub_date
2018-05-01 00:00:00pages
322-333issue
5eissn
0198-8859issn
1879-1166pii
S0198-8859(18)30020-Xjournal_volume
79pub_type
杂志文章,评审相关文献
HUMAN IMMUNOLOGY文献大全abstract::The purpose of this study was to examine the expression of human leukocyte antigen-G (HLA-G) in patients with systemic lupus erythematosus (SLE) and its relation with interleukin-10 (IL-10) production. The study included 50 female SLE patients and 59 healthy female donors. HLA-G expression in peripheral blood and cuta...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.11.001
更新日期:2008-01-01 00:00:00
abstract::The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00041-7
更新日期:2003-05-01 00:00:00
abstract::The immunomodulatory properties of soluble human leukocyte antigen G (sHLA-G) explain its potential interest in malignancies. HLA-G frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. In this article, we will demonstrate that the plasmatic level of soluble HLA-G was significant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2003.08.345
更新日期:2003-11-01 00:00:00
abstract::Our purpose was to investigate a possible relationship between severe early childhood caries (S-ECC) and polymorphism of the mannose binding lectin gene and investigate the role of allele variant as a possible factor in the susceptibility to S-ECC. Sixty-two Chinese children with S-ECC and 68 caries-free control child...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.08.012
更新日期:2013-01-01 00:00:00
abstract::Alleles of the C*07:01/07:06/07:18 group is distinguished by polymorphisms in exons 5-6. In a previous study, we focused on exons 2-3 of the gene and showed that 6.8% of Koreans express alleles in this group. In this study, we identified allelic and haplotypic diversities of the C*07:01/07:06/07:18 group in Koreans. A...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.05.002
更新日期:2011-09-01 00:00:00
abstract::The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)90090-6
更新日期:1994-09-01 00:00:00
abstract::HLA-DQ molecules were isolated from DRw9-homozygous and DR4-homozygous cell lines by using a monoclonal antibody HU-18, which recognizes class II molecules carrying the conventional DQw3 determinant. The partial N-terminal sequence analysis of the DQw3 molecules revealed that they have sequences homologous to those of...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90061-8
更新日期:1985-09-01 00:00:00
abstract::The Human Leukocyte Antigen-G has immunomodulatory function and its expression has been associated with several diseases. In our study we analyzed HLA-G polymorphisms in order to evaluate their possible association with susceptibility to celiac disease development. A total of 420 celiac patients and 509 controls were ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2014.12.006
更新日期:2015-01-01 00:00:00
abstract::Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.011
更新日期:2016-06-01 00:00:00
abstract::The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00213-5
更新日期:2000-12-01 00:00:00
abstract::An interesting class of immune responses is that in which an environmental agent modifies a self-protein. Heparin induced thrombocytopenia (HIT) is associated with an antibody response in which the immunogen is a self-protein, platelet factor 4 (PF4), modified by an external agent, heparin. We tested the hypothesis th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00242-1
更新日期:2001-02-01 00:00:00
abstract::A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.06.003
更新日期:2007-09-01 00:00:00
abstract::Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.014
更新日期:2008-11-01 00:00:00
abstract::Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Changing concentrations of transcriptional cofactors or chemicals in transiently transfected tissue culture cells modify several properties of glucocorticoid receptor-regulated gene expression including total activity (A(max)...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.029
更新日期:2009-10-01 00:00:00
abstract::We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00107-4
更新日期:1999-02-01 00:00:00
abstract::Better outcome for hematopoietic stem cell transplantation (HSCT) requires optimal matching between donor and recipient at the HLA-A, -B, -C, and -DRB1 loci. This study estimates the likelihood of identifying HLA matched donors in Hong Kong. 7595 volunteer unrelated Chinese donors at the Hong Kong Bone Marrow Donor Re...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.08.007
更新日期:2017-10-01 00:00:00
abstract::T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90060-0
更新日期:1984-12-01 00:00:00
abstract::The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.012
更新日期:2009-10-01 00:00:00
abstract::Of 188 cases of Kaposi's sarcoma arising de novo after transplantation, HLA-A, -B typing was available for 135 and HLA-DR typing available for 67. Compared to the reported HLA phenotype frequencies of renal transplant recipients in the Southeast Organ Procurement Foundation (SEOPF), there is a significantly decreased ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90069-2
更新日期:1990-09-01 00:00:00
abstract::Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.12.002
更新日期:2017-02-01 00:00:00
abstract::The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.003
更新日期:2018-03-01 00:00:00
abstract::There is a growing body of information about the soluble forms of HLA in serum but there are only a few reports discussing sHLA in other body fluids. We quantitated sHLA-I and sHLA-II concentrations in sweat, saliva and tear samples from five normal individuals with known HLA-phenotypes. We also studied sweat samples ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00122-0
更新日期:1999-03-01 00:00:00
abstract::It has been known for some time that transplant recipients may have antibodies to endothelial cells which are not detected on lymphocytes. However, little progress has been made in the analysis of these endothelial antigens. In the present experiments we have attempted to characterize endothelial cell surface antigens...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.05.002
更新日期:2013-11-01 00:00:00
abstract::HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...
journal_title:Human immunology
pub_type: 多中心研究
doi:10.1016/s0198-8859(01)00305-6
更新日期:2001-10-01 00:00:00
abstract::This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor alpha, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00324-x
更新日期:2001-11-01 00:00:00
abstract:HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.05.005
更新日期:2018-08-01 00:00:00
abstract::The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00175-4
更新日期:1997-09-15 00:00:00
abstract::Our objective was to study a possible contribution of MHC genes to S-HLA-I secretion in patients with Type I diabetes. Quantitatively, we used a highly sensitive enzyme-linked immunoassay to measure S-HLA-I in the serum of a total of 39 patients with Type I diabetes, as well as 36 kinships of 12 diabetic patients and ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00096-7
更新日期:1997-07-01 00:00:00
abstract::The polymorphic MICA gene encodes glycoproteins that activate T cells and NK cells through the NKG2D receptor and may costimulate immune functions. We found that MICA was expressed on freshly isolated human fibroblasts and was markedly decreased when fibroblasts were grown to confluency in culture dishes. MICA surface...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.018
更新日期:2006-03-01 00:00:00
abstract::Soluble human leukocyte antigen-G molecules (HLA-G5) can be found in the peripheral blood of healthy females and males, and in other body fluids. To identify cells secreting HLA-G5 we generated a rabbit antiserum against a peptide motif encoded by intron-4 of HLA-G (RaHLA-G/I-4). Utilizing this antiserum as capture an...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2003.08.354
更新日期:2003-11-01 00:00:00