Abstract:
:Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study, we identified LILRB2 as an upregulated gene in septic shock patients. On monocytes primed with LPS ex vivo, LILRB2 mRNA and protein expressions were dose-dependently downregulated and subsequently highly upregulated versus non-stimulated cells. This is concordant with clinical data, since both LILRB2 mRNA and protein expressions were significantly increased in septic shock patients at day 3. In a cohort of more than 700 patients, only after septic shock were LILRB2 mRNA levels increased compared with non-infected or less severely infected patients. This was preceded by a phase of downregulated mRNA expression during the first hours after septic shock. Interestingly, the intensity of this decrease was associated with increased risk of death after septic shock. LILRB2 protein and mRNA expressions are deregulated on monocytes after septic shock and this can be reproduced ex vivo after LPS challenge. Considering LILRB2 inhibitory properties, we can hypothesize that LILRB2 may participate in the altered immune response after septic shock.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Venet F,Schilling J,Cazalis MA,Demaret J,Poujol F,Girardot T,Rouget C,Pachot A,Lepape A,Friggeri A,Rimmelé T,Monneret G,Textoris Jdoi
10.1016/j.humimm.2017.03.010subject
Has Abstractpub_date
2017-01-01 00:00:00pages
441-450issue
5-6eissn
0198-8859issn
1879-1166pii
S0198-8859(17)30050-2journal_volume
78pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::"Those who do not know the past are destined to repeat it". The current system for the allocation of deceased donor kidneys that was implemented in December 2014 (termed the kidney allocation system (KAS)) was the culmination of a decade-long process. Thus, many people involved in transplantation today may not be awar...
journal_title:Human immunology
pub_type: 历史文章,杂志文章
doi:10.1016/j.humimm.2016.08.008
更新日期:2017-01-01 00:00:00
abstract::Mannose-binding lectin (MBL) role in the carriage of oropharyngeal bacteria is not known. We investigated the association of smoking, MBL2 polymorphisms, and MBL concentrations with oropharyngeal carriage of respiratory bacteria in young men. Oropharyngeal specimens, MBL concentrations, and MBL2 gene polymorphisms wer...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.12.009
更新日期:2010-03-01 00:00:00
abstract::Monoclonal antibodies have played an important role in studying the biochemistry of the HLA-Class I molecules. Some murine anti-HLA mAbs can identify configurations of HLA epitopes that have never been reported in human allosera. One of these configurations is identified by an IgM mAb designated as: BHA-1441. This ant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00254-3
更新日期:2001-07-01 00:00:00
abstract::DOCK10 is a member of the dedicator of cytokinesis (DOCK) family of Rho GTPase activators preferentially expressed in lymphocytes. In this paper, we analyzed DOCK10 mRNA diversity produced because of alternative splicing. Alternative first coding exon usage led to 2 main protein-coding transcripts, DOCK10.1 and DOCK10...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.03.024
更新日期:2011-07-01 00:00:00
abstract::4-Hydroxynonenal (HNE) is the most abundant and toxic aldehyde generated by the oxidation of plasma membrane polyunsaturated fatty acids. Systemic lupus erythematosus (SLE), a chronic autoimmune disease, is primarily characterized by increased levels of autoantibodies, predominantly against ds-DNA. However, the initia...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.08.011
更新日期:2012-11-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.01.011
更新日期:2007-05-01 00:00:00
abstract::The aim of this study was to test whether the functional variant rs2076530 of the BTNL2 gene confers susceptibility to the autoimmune diseases type 1 diabetes (T1D), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Our study populations consisted of 326 patients with T1D and 351 healthy subjects, 808...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.003
更新日期:2005-12-01 00:00:00
abstract::We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two E...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.05.015
更新日期:2020-09-01 00:00:00
abstract::The polymorphic nature of the KIR3DL1/S1 gene complex has been investigated through the development of a polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) allele typing system. The KIR3DL1/S1 system was applied to a healthy group of Northern Irish individuals to establish allele frequencies...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.03.003
更新日期:2004-06-01 00:00:00
abstract::Only 10% of persons infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB), indicating the existence of host genetic factors regulating disease expression. We investigated the association of human leukocyte antigen (HLA) class II genes with the susceptibility to pulmonary TB in Koreans, with speci...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.08.242
更新日期:2005-10-01 00:00:00
abstract::Immunoglobulin idiotypes (Id) of malignant B cells represent highly specific markers which can be used for vaccination. PCR-amplification of immunoglobulin genes enables the rapid production of large amounts of Id vaccines. However, the separate amplification and subsequent recombination of heavy and light chains can ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00145-6
更新日期:1997-08-01 00:00:00
abstract::The HER-2/neu protein is overexpressed in approximately 20% of human adenocarcinomas and is a defined tumor antigen in breast cancer. The purpose of this study was to evaluate the endogenous HER-2/neu specific antibody response in 57 patients with colorectal cancer. HER-2/neu specific antibodies, titer > or = 1:100, w...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00003-8
更新日期:1999-06-01 00:00:00
abstract::A certain HLA-DQA2 locus TaqI fragment, DX alpha"U", has been reported to be associated with insulin-dependent diabetes mellitus (IDDM). Reports of various studies in this vein have ranged from stating that the association of DQA2"U" with IDDM exists even among subjects positive for HLA-DR3 and -DR4 to stating that th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90039-r
更新日期:1990-12-01 00:00:00
abstract::A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We hav...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(83)80011-1
更新日期:1983-06-01 00:00:00
abstract::From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from b...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(91)90071-g
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Accurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome. METHODS:HLA genes expression analy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.05.002
更新日期:2018-08-01 00:00:00
abstract::Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.08.267
更新日期:2013-12-01 00:00:00
abstract::To identify disease-specific T cell changes that occur in Crohn's disease (CD) the T-cell receptor (TCR) BV repertoires of lamina propria lymphocytes (LPL) from both disease-active and disease-inactive colonic tissue of three CD patients were compared by a quantitative polymerase chain reaction (qPCR) and CDR3 length ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(96)00079-1
更新日期:1996-06-01 00:00:00
abstract::Perforin (PRF1) gene mutations have been associated with Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2). Substitution p.A91V (c.272C>T) in exon 2 was first described as a neutral polymorphism. Nonetheless, recent clinical evidence and functional assays, suggest a potential pathogenic role for p.A91V, especi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.10.011
更新日期:2013-01-01 00:00:00
abstract::Conventional matching is based on numbers of alleles shared between donor and recipient. This approach, however, ignores the degree of relationship between alleles and haplotypes, and therefore the actual degree of difference. To address this problem, we have compared family members using a block matching technique wh...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00231-0
更新日期:1998-01-01 00:00:00
abstract::Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our resul...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(91)90085-n
更新日期:1991-12-01 00:00:00
abstract::The 2',5'-oligoadenylate synthetase 1 (OAS1) is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection. A single nucleotide polymorphism (SNP), rs10774671, presumably responsible for alternate splicing of this gene, has frequently been associated with...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.11.011
更新日期:2013-03-01 00:00:00
abstract::Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of inflammatory bowel disease (IBD) in a New Zealand Caucasian case-cont...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.03.002
更新日期:2009-06-01 00:00:00
abstract::A typing system for HLA-D/DR-associated PLT-defined determinants, which have been called "DP" antigens, is reported. Some of the results concerning a data interpretation system, the reproducibility of PLT results, and the correlations between the results of HLA-D, -DR, and DP typing are presented. Also, a "new" human ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90035-5
更新日期:1981-07-01 00:00:00
abstract::Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.006
更新日期:2010-05-01 00:00:00
abstract::M proteins are coiled-coil dimers expressed on group A streptococcal cell surfaces. They have an important role in host antistreptococcal immunity and in poststreptococcal autoimmune sequelae. Controversy has arisen regarding whether type 5 M proteins are superantigenic for human T cells. To investigate this, we have ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/S0198-8859(97)00028-1
更新日期:1997-04-01 00:00:00
abstract::Sera obtained from multiparous women and some of other origin contain antibodies which react with antigens on T cell subsets. These antibodies recognize two distinct diallelic systems, one of which is mainly present on T gamma cells while the other is present on T mu cells. The sera that reacted with the T gamma cells...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90011-8
更新日期:1982-04-01 00:00:00
abstract::HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.038
更新日期:2006-04-01 00:00:00
abstract::In attempts to examine the relationships between serologic and structural polymorphisms of HLA-DQ molecules we have analyzed several monoclonal antibodies generated against polymorphic determinants on HLA-DQ molecules. One antibody, SFR20-DQw3, has a serologic reactivity like that of the previously characterized anti-...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(87)90076-0
更新日期:1987-04-01 00:00:00
abstract::In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90005-0
更新日期:1989-12-01 00:00:00