Streptococcus pyogenes type 5 M protein is an antigen, not a superantigen, for human T cells.

abstract：BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...

journal_title：Human immunology

authors： da Costa Lima Caniatti MC,Borelli SD,Guilherme AL,Tsuneto LT

更新日期：2017-02-01 00:00:00

abstract：:Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...

journal_title：Human immunology

authors： Tassiulas I,Park-Min KH,Hu Y,Kellerman L,Mevorach D,Ivashkiv LB

更新日期：2007-03-01 00:00:00

abstract：:To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlant...

journal_title：Human immunology

authors： Oumhani K,Canossi A,Piancatelli D,Di Rocco M,Del Beato T,Liberatore G,Aureli A,Benjoaud A,El Aouad R,Adorno D,Casciani CU

更新日期：2002-02-01 00:00:00

abstract：HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...

journal_title：Human immunology

authors： Seshasubramanian V,Manisekar NK,Sathishkannan AD,Naganathan C,Narayan S

更新日期：2018-08-01 00:00:00

abstract：:The HLA-DRB3 gene, which encodes the supertypic HLA-DRw52 antigen, has been shown to have limited polymorphism. The alleles at this locus are also in linkage disequilibrium with the alleles at the DRB1 locus. We have studied 16 DRw11 and three DRw12 haplotypes in the South African populations. Five of the DRw11,DQw7 h...

journal_title：Human immunology

authors： Martell RW,Oudshoorn M,Arendse B,du Toit ED

更新日期：1990-05-01 00:00:00

abstract：:Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infections. In humans, MUC1 is highly polymorphic, predominantly due to the presence of a variable number tandem repeat (VNTR) region in the extracellular domain that results in MUC1 molecules of...

journal_title：Human immunology

authors： Dhar P,Sarkar S,Ng GZ,Kalitsis P,Saeed MA,McGuckin MA,Ellis JA,Sutton P

更新日期：2019-10-01 00:00:00

abstract：:A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We hav...

journal_title：Human immunology

authors： Shaut DM,Ireland J,Scornik JC,Peck AB

更新日期：1983-06-01 00:00:00

abstract：:CD1 glycoproteins are a class of antigen presenting molecules that bind and present non-peptidic antigens (lipids and glycolipids) for immune recognition. CD1 polymorphisms, although limited, could have a critical role in antimicrobial, anticancer, and autoimmune responses and disease susceptibility. Ethnic difference...

journal_title：Human immunology

authors： Aureli A,Aboulaghras S,Oumhani K,Del Beato T,Sebastiani P,Colanardi A,El Aouad R,Ben El Barhdadi I,Piancatelli D

更新日期：2020-07-01 00:00:00

abstract：:MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...

journal_title：Human immunology

authors： Di Rosa F,D'Oro U,Ruggiero G,Racioppi L,Acquaviva A,Ferrone S,Fontana S,Zappacosta S

更新日期：1993-12-01 00:00:00

abstract：:Of 188 cases of Kaposi's sarcoma arising de novo after transplantation, HLA-A, -B typing was available for 135 and HLA-DR typing available for 67. Compared to the reported HLA phenotype frequencies of renal transplant recipients in the Southeast Organ Procurement Foundation (SEOPF), there is a significantly decreased ...

journal_title：Human immunology

authors： Brunson ME,Balakrishnan K,Penn I

更新日期：1990-09-01 00:00:00

abstract：:The cellular basis of graft rejection and the development of strategies for specific suppression of T cell responses against allogeneic and xenogeneic transplants represents an area of active investigation. Recently, a population of MHC-class I restricted CD8+CD28- T suppressor cells (Ts) which are able to inhibit spe...

journal_title：Human immunology

authors： Pennesi G,Liu Z,Ciubotariu R,Jiang S,Colovai A,Cortesini R,Suciu-Foca N,Harris P

更新日期：1999-04-01 00:00:00

abstract：:Indirect immunofluorescence staining with monoclonal antibodies has shown a differential distribution of HLA-DR, DQ, and DP antigens in normal tissues of nonlymphoid origin. The distribution of HLA-DP antigens is similar to that of HLA-DR antigens, while that of HLA-DQ antigens is more restricted. Malignant transforma...

journal_title：Human immunology

authors： Natali P,Bigotti A,Cavalieri R,Nicotra MR,Tecce R,Manfredi D,Chen YX,Nadler LM,Ferrone S

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:When donor specific HLA antibodies (DSA) are identified, the predictive value of whether a certain strength of reactivity (mean fluorescence intensity, MFI) leads to a positive crossmatch is uncertain. To determine this, we compared the DSA MFI results we generated locally for nationally distributed proficiency...

journal_title：Human immunology

authors： Wrenn SM,Marroquin CE,Hain DS,Harm SK,Pineda JA,Hammond PB,Shah DH,Hillyard SE,Fung MK

更新日期：2018-08-01 00:00:00

abstract：:HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...

journal_title：Human immunology

authors： Faner R,Casamitjana N,Coll J,Caro P,Pujol-Borrell R,Palou E,Juan M

更新日期：2006-04-01 00:00:00

abstract：:Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...

journal_title：Human immunology

authors： Dean RR,Kilduff TS,Dement WC,Grumet FC

更新日期：1989-05-01 00:00:00

abstract：:Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...

journal_title：Human immunology

authors： Lee N,Shin MS,Kang Y,Park K,Maeda T,Nishioka H,Fujii H,Kang I

更新日期：2016-06-01 00:00:00

abstract：:TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...

journal_title：Human immunology

authors： Dave VP,Larché M,Rencher SD,Koop BF,Hurwitz JL

更新日期：1993-07-01 00:00:00

abstract：:The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wil...

journal_title：Human immunology

authors： Viken HD,Paulsen G,Drover S,Marshall WH,Sollid LM,Gaudernack G,Thorsby E

更新日期：1995-10-01 00:00:00

abstract：:Quechua Amerindians established Inca Empire and chose Cuzco as their capital. Their language is closely related to that of Aymara ethnic group and both of them were originated from Titikaka Lake Altiplano area. In the present study we have analyzed Bolivian Quechua HLA profile and found that it has common characters w...

journal_title：Human immunology

authors： Arnaiz-Villena A,Juarez I,Lopez-Nares A,Crespo-Yuste E,Callado A,Suarez-Trujillo F

更新日期：2020-07-01 00:00:00

abstract：:Immunoglobulin idiotypes (Id) of malignant B cells represent highly specific markers which can be used for vaccination. PCR-amplification of immunoglobulin genes enables the rapid production of large amounts of Id vaccines. However, the separate amplification and subsequent recombination of heavy and light chains can ...

journal_title：Human immunology

authors： Terness P,Welschof M,Moldenhauer G,Jung M,Moroder L,Kirchhoff F,Kipriyanov S,Little M,Opelz G

更新日期：1997-08-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) play an important role in the regulation and suppression of immune responses to self- and foreign antigens. Suppressed and impaired host immune responses are a major characteristic of many persistent human virus infections, such as those caused by human immunodeficiency virus (HIV), h...

journal_title：Human immunology

authors： Billerbeck E,Thimme R

更新日期：2008-11-01 00:00:00

abstract：:The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 5...

journal_title：Human immunology

authors： Bojko A,Ostasz R,Białecka M,Klimowicz A,Malinowski D,Budawski R,Bojko P,Droździk M,Kurzawski M

更新日期：2018-04-01 00:00:00

abstract：:Pregnancy can prime the maternal humoral immune response against paternal human leukocyte antigens (HLA) of the child. Previous studies have reported that formation of antibodies against inherited paternal HLA is associated with the presence of primed cytotoxic T lymphocytes (CTLs) specific for these antigens. Recentl...

journal_title：Human immunology

authors： van Kampen CA,Versteeg-vd Voort Maarschalk MF,Langerak-Langerak J,Roelen DL,Claas FH

更新日期：2002-06-01 00:00:00

abstract：:Our purpose was to investigate a possible relationship between severe early childhood caries (S-ECC) and polymorphism of the mannose binding lectin gene and investigate the role of allele variant as a possible factor in the susceptibility to S-ECC. Sixty-two Chinese children with S-ECC and 68 caries-free control child...

journal_title：Human immunology

authors： Yang Y,Wang W,Qin M

更新日期：2013-01-01 00:00:00

abstract：:Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our resul...

journal_title：Human immunology

authors： Reed AM,Pachman L,Ober C

更新日期：1991-12-01 00:00:00

abstract：:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...

journal_title：Human immunology

authors： Deulofeut H,Wilderson JL,Barron KS,Robinson MA

更新日期：1995-07-01 00:00:00

abstract：:HLA-G molecule has considerable impact in various clinical fields, therefore many studies attempted to predict its expression based on HLA-G genotype. These studies have focused on polymorphisms in either the coding region or in one of the two untranslated regions (UTR) of the gene. The aim of our study was to determi...

journal_title：Human immunology

authors： Di Cristofaro J,El Moujally D,Agnel A,Mazières S,Cortey M,Basire A,Chiaroni J,Picard C

更新日期：2013-02-01 00:00:00

abstract：:To identify the existence of antigen specific T cell responses and to follow the changes of these reactions, it is considered useful to evaluate whether certain T cells clonally accumulate in the lymphocyte population. For this purpose, we have established a novel method to analyze T cell clonality using a combination...

journal_title：Human immunology

authors： Yamamoto K,Masuko-Hongo K,Tanaka A,Kurokawa M,Hoeger T,Nishioka K,Kato T

更新日期：1996-06-01 00:00:00

abstract：:In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...

journal_title：Human immunology

authors： Gorski J,Niven MJ,Sachs JA,Mach B,Cassell PG,Festenstein H,Awad J,Hitman GA

更新日期：1987-12-01 00:00:00

abstract：:Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...

journal_title：Human immunology

authors： Hetrick SJ,Schillinger KP,Zachary AA,Jackson AM

更新日期：2011-04-01 00:00:00