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Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids.

Abstract：

:The Ia-like antigens of hybrids of the B-lymphoblastoid cell line (B-LCL) WI-L2 and a subline of the T-lymphoblastoid cell line (T-LCL) HSB were examined. Antigens of the HLA-DR and MT series were analyzed by indirect immunofluorescence with chimpanzee anti-DR sera and monoclonal antibodies, and antigens of the SB series were analyzed by primed lymphocyte typing (PLT). The WI-L2 X HSB hybrids expressed antigens of each series not found on either parent cell. In each case, the novel antigens were indistinguishable from those found on SB, a B-LCL established from the same individual as HSB, and are thus presumably HSB encoded.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Howell DN,Hartzman RJ,Cresswell P

doi

10.1016/0198-8859(83)90011-3

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

167-75

issue

2

eissn

0198-8859

issn

1879-1166

pii

0198-8859(83)90011-3

journal_volume

8

pub_type

杂志文章

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