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Complex associations between HLA-DRB1 genes and female rheumatoid arthritis: results from a prospective study.

Abstract：

:We followed 138 Spanish patients (37 men and 101 women) with rheumatoid arthritis (RA) to analyze whether patient sex influenced the HLA-DRB1 associations with disease susceptibility. Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specificities differs from males to females: DR1 was increased among male patients, whereas DR4 as well as DR10 were preferentially associated with female RA. To further explore whether this phenomenon operates either on susceptibility or on disease progression, 82 patients (25 males and 57 females) among the whole group were followed during the first 8 to 10 years of their disease. Results from this prospective study showed that the association of the SE with radiological disease severity was found in both male and female patients, although it was stronger among the latter group. Interestingly, DR1- as well as DR4-related alleles contributed to the high frequency of SE among female patients with early small-joints severe RA and/or long-term large-joint erosions. These results suggest that HLA polymorphism might be involved in RA pathogenesis through two mechanisms: (a) in combination with patient sex, operating in disease induction; and (b) independent of patient sex, influencing disease severity and progression.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Gonzalez-Escribano MF,Rodriguez R,Valenzuela A,Garcia A,Núñez-Roldan A

doi

10.1016/s0198-8859(99)00119-6

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1259-65

issue

12

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(99)00119-6

journal_volume

60

pub_type

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