IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis.

abstract：:Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...

journal_title：Human immunology

authors： Pennesi G,Brioli G,Lulli P,Mariani B,Morellini M,Nicotra M,Trabace S

更新日期：1998-06-01 00:00:00

abstract：:There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...

journal_title：Human immunology

authors： Bangham CR,Bushell A,Wood KJ,Morris PJ

更新日期：1988-02-01 00:00:00

abstract：:The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms a...

journal_title：Human immunology

authors： Lemos MC,Fagulha A,Coutinho E,Gomes L,Bastos M,Barros L,Carrilho F,Geraldes E,Regateiro FJ,Carvalheiro M

更新日期：2008-02-01 00:00:00

abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

journal_title：Human immunology

authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

更新日期：1997-09-15 00:00:00

abstract：:We compared the T cell receptor (TCR) V beta gene family repertoire in peripheral blood mononuclear cells (PBMC) and lymph node (LN) cells from 7 human immunodeficiency virus (HIV)-infected patients and 3 seronegative healthy controls. Virtually all the V beta family specificities were represented in patient PBMC and ...

journal_title：Human immunology

authors： Mion M,Indraccolo S,Feroli F,Minuzzo S,Masiero S,Zamarchi R,Barelli A,Borri A,Chieco-Bianchi L,Amadori A

更新日期：1997-10-01 00:00:00

abstract：:The loss of melanocytes in vitiligo is mainly attributed to defective autoimmune mechanisms and lately autoinflammatory mediators have become more emphasized. Among these, a number of class II cytokines and their receptors have displayed altered expression patterns in vitiligo. Thus, we selected 30 SNPs from the regio...

journal_title：Human immunology

authors： Traks T,Karelson M,Reimann E,Rätsep R,Silm H,Vasar E,Kõks S,Kingo K

更新日期：2016-05-01 00:00:00

abstract：:One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...

journal_title：Human immunology

authors： De Maria A,Moretta L

更新日期：2000-01-01 00:00:00

abstract：:Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis. Here, we investigate the clinical significance of FCN2 in African children with either mild or severe malaria (n = 130 and n = 108, respectively) from Gabon by analyzing three promote...

journal_title：Human immunology

authors： Faik I,Oyedeji SI,Idris Z,de Messias-Reason IJ,Lell B,Kremsner PG,Kun JF

更新日期：2011-01-01 00:00:00

abstract：:Based upon observations in murine models, we have developed protocols to induce renal allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non-human primates (NHP) and in humans. Induction of persistent mixed chimerism has proved to be extremely difficult in major histocompatibility comple...

journal_title：Human immunology

authors： Sasaki H,Oura T,Spitzer TR,Chen YB,Madsen JC,Allan J,Sachs DH,Cosimi AB,Kawai T

更新日期：2018-05-01 00:00:00

abstract：:The 2',5'-oligoadenylate synthetase 1 (OAS1) is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection. A single nucleotide polymorphism (SNP), rs10774671, presumably responsible for alternate splicing of this gene, has frequently been associated with...

journal_title：Human immunology

authors： Noguchi S,Hamano E,Matsushita I,Hijikata M,Ito H,Nagase T,Keicho N

更新日期：2013-03-01 00:00:00

abstract：:We have found that 4H84 monoclonal antibody (mAb) used for detection of beta2m free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta2m free classical HLA class I molecules induced on the surface of acti...

journal_title：Human immunology

authors： Poláková K,Kuba D,Russ G

更新日期：2004-02-01 00:00:00

abstract：:Immunoglobulin idiotypes (Id) of malignant B cells represent highly specific markers which can be used for vaccination. PCR-amplification of immunoglobulin genes enables the rapid production of large amounts of Id vaccines. However, the separate amplification and subsequent recombination of heavy and light chains can ...

journal_title：Human immunology

authors： Terness P,Welschof M,Moldenhauer G,Jung M,Moroder L,Kirchhoff F,Kipriyanov S,Little M,Opelz G

更新日期：1997-08-01 00:00:00

abstract：:A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We hav...

journal_title：Human immunology

authors： Shaut DM,Ireland J,Scornik JC,Peck AB

更新日期：1983-06-01 00:00:00

abstract：:A certain HLA-DQA2 locus TaqI fragment, DX alpha"U", has been reported to be associated with insulin-dependent diabetes mellitus (IDDM). Reports of various studies in this vein have ranged from stating that the association of DQA2"U" with IDDM exists even among subjects positive for HLA-DR3 and -DR4 to stating that th...

journal_title：Human immunology

authors： Rowe JR,Neme de Gimenez MH,Emler CA,Sheehy MJ

更新日期：1990-12-01 00:00:00

abstract：:Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...

journal_title：Human immunology

authors： Gedde-Dahl T 3rd,Eriksen JA,Thorsby E,Gaudernack G

更新日期：1992-04-01 00:00:00

abstract：:A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequ...

journal_title：Human immunology

authors： Arrieta-Bolaños E,Madrigal-Sánchez JJ,Stein JE,Moreira-Espinoza MJ,Paredes-Carias E,Vanegas-Padilla Y,Salazar-Sánchez L,Madrigal JA,Marsh SGE,Shaw BE

更新日期：2019-07-01 00:00:00

abstract：:Previously, most models that sought to explain the misregulation of immune cell function assumed molecular similarities between the disease-causing pathogens and the host's proteins. In recent time several different models have been proposed and in this study, these concepts are compared to a new hypothesis proposing ...

journal_title：Human immunology

authors： Arneth BM

更新日期：2009-09-01 00:00:00

abstract：:In order to characterize directly the T-cell repertoire utilized in human renal allograft rejection, we analyzed 20 long-term T-cell lines established from lymphocytic infiltrates present in renal tissue obtained by needle biopsy from transplant patients with rejection indications. All cell lines are strongly cytotoxi...

journal_title：Human immunology

authors： Miceli MC,Barry TS,Finn OJ

更新日期：1988-07-01 00:00:00

abstract：:To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...

journal_title：Human immunology

authors： Lee YJ,Woo M,Nam JH,Baek J,Im CH,Lee EY,Lee EB,Park KS,Song YW

更新日期：2008-06-01 00:00:00

abstract：:Comparison of human leukocyte antigen (HLA) frequencies in patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and in patients with HCV-associated non-Hodgkin's lymphoma (NHL) has not been addressed previously. To this aim, we investigated the distribution of HLA class II alleles in two sel...

journal_title：Human immunology

authors： De Re V,Caggiari L,Talamini R,Crovatto M,De Vita S,Mazzaro C,Cannizzaro R,Dolcetti R,Boiocchi M

更新日期：2004-11-01 00:00:00

abstract：:Of 188 cases of Kaposi's sarcoma arising de novo after transplantation, HLA-A, -B typing was available for 135 and HLA-DR typing available for 67. Compared to the reported HLA phenotype frequencies of renal transplant recipients in the Southeast Organ Procurement Foundation (SEOPF), there is a significantly decreased ...

journal_title：Human immunology

authors： Brunson ME,Balakrishnan K,Penn I

更新日期：1990-09-01 00:00:00

abstract：:Felty's syndrome (FS) is a rare complication of rheumatoid arthritis (RA) previously shown to be strongly associated with HLA-DR4 and less significantly with HLA-DQw7. To map more precisely the HLA locus responsible for susceptibility to FS, we have examined HLA-DR4 and DQ beta-chain polymorphisms in FS patients and c...

journal_title：Human immunology

authors： Lanchbury JS,Jaeger EE,Sansom DM,Hall MA,Wordsworth P,Stedeford J,Bell JI,Panayi GS

更新日期：1991-09-01 00:00:00

abstract：:The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...

journal_title：Human immunology

authors： Jugdé F,Boissier C,Birebent B,Vu N,D'halluin PN,Rioux-Leclercq N,Bretagne JF,Semana G,Heresebach D

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Leucocyte infiltration and activation in the central nervous system (CNS) is an important step in the pathogenesis of multiple sclerosis (MS). The Chemokine receptor 5 (CCR5) is implicated in immune cell migration and cytokine release in the CNS, and it was demonstrated to strongly contribute to CNS inflamma...

journal_title：Human immunology

authors： Troncoso LL,Pontillo A,Oliveira EML,Finkelszteijn A,Schneider S,Chies JAB

更新日期：2018-08-01 00:00:00

abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

journal_title：Human immunology

authors： Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

更新日期：1999-01-01 00:00:00

abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...

journal_title：Human immunology

authors： Jackson DG,Capra JD

更新日期：1995-05-01 00:00:00

abstract：:Many studies have shown that Human leukocyte antigen (HLA) class I alleles are associated with the development of various cancers. However, its role in hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class I allelic polymorphism is related to the development of hepatitis B virus(HBV)-associ...

journal_title：Human immunology

authors： Pan N,Chen K,Qiu J,Sun H,Xu J,Miao F,Shi Q,Jiang W,Jin H,He Y,Xie W,Zhang J

更新日期：2013-06-01 00:00:00

abstract：:Genomic aberrations in the CREBBP (CREB-binding protein - CREBBP or CBP) gene such as point mutations, small insertions or exonic copy number changes are usually associated with Rubinstein-Taybi syndrome (RTs). In this study, the disruption of the CREBBP gene on chromosome 16p13.3, as revealed by CGH-array and FISH, s...

journal_title：Human immunology

authors： Torres LC,Kulikowski LD,Ramos PL,Sugayama SM,Moreira-Filho CA,Carneiro-Sampaio M

更新日期：2013-08-01 00:00:00

abstract：:Six murine monoclonal antibodies raised against sheep MHC class II molecules were analyzed for reactivity with HLA-D subregion products. All the antibodies reacted with human peripheral blood lymphocytes, monocytes, and B-lymphoblastoid cell lines homozygous for various HLA-DR specificities, suggesting that the antibo...

journal_title：Human immunology

authors： Puri NK,de Kretser T,Brandon MR

更新日期：1987-11-01 00:00:00

abstract：:Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...

journal_title：Human immunology

authors： Lucotte G,Gérard N,Mercier G

更新日期：2001-09-01 00:00:00