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Narcolepsy without unique MHC class II antigen association: studies in the canine model.

Abstract：

:Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed leukocyte culture (MLC) was used to study differences in the canine MHC class II (DLA-D) antigens present in narcoleptic dogs to determine whether an analogous, unique DLA-D antigen could be identified in canine narcolepsy. Results show at least five different DLA-D antigens appear in potential narcoleptic haplotypes among the 29 dogs studied. The data demonstrate that, unlike man, in dogs there is no unique D locus antigen associated with narcolepsy and further suggest that linkage disequilibrium with a specific MHC antigen is unlikely to be essential for the manifestation of canine narcolepsy. Because human narcolepsy is thought to be multigenic, the canine narcolepsy-MHC dissociation suggests that the dog model may help elucidate the non-MHC narcolepsy gene(s).

journal_name

Hum Immunol

journal_title

Human immunology

authors

Dean RR,Kilduff TS,Dement WC,Grumet FC

doi

10.1016/0198-8859(89)90067-0

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

27-35

issue

1

eissn

0198-8859

issn

1879-1166

pii

0198-8859(89)90067-0

journal_volume

25

pub_type

杂志文章

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