Abstract：
:Using TCR-specific mAbs, we analyzed the TCR distribution in the CD4 and CD8 compartments of peripheral blood T cells from members of six families, including two which were informative for an HLA-B/DR crossover. TCR distribution in the CD4 compartment is influenced by MHC class II antigens as it was similar in the child carrying the HLA-B/DR recombination and in the HLA-DR-identical sibling. There was also a relatively small degree of difference between TCR distribution in the CD8 compartment of a child with an HLA-B/DR crossover and his HLA class-I-identical sibling. Analysis of TCR V beta gene usage in the CD4 compartment of unrelated individuals sharing an HLA-DR allele showed an increased usage of V beta 8a and V beta 12a in DR4-positive subjects. These data suggest that studies of TCR V beta gene usage in individuals with HLA-associated autoimmune diseases may provide further information about MHC-dependent biases in the T-cell repertoire.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Reed EF,Tugulea SL,Suciu-Foca Ndoi
10.1016/0198-8859(94)90055-8subject
Has Abstractpub_date
1994-06-01 00:00:00pages
111-22issue
2eissn
0198-8859issn
1879-1166pii
0198-8859(94)90055-8journal_volume
40pub_type
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