Why cord blood?


:Cord blood, donated by mothers after the birth of their children, has become an accepted source of related and unrelated hematopoietic stem cells for marrow reconstitution. We estimate that some 7-8000 unrelated-donor cord blood transplants have been performed worldwide since 1993. The development of cord blood as a source of hematopoietic stem cells for transplantation started with the early recognition of the presence in cord blood of colony-forming cells by Knudtzon in 1974. The first cord blood transplant from a human leukocyte antigen (HLA)-identical sib to a young patient with Fanconi anemia was performed by Gluckman in 1988 and opened the way for the subsequent development of a bank for donations for unrelated patients by our group at the New York Blood Center. It is now widely recognized that two transplant-dependent variables exert strong influence on the chance for long-term recipient survival: the hematopoietic stem and progenitor cell dose and the HLA match grade. Hence, despite the generally milder graft-vs-host disease after mismatched cord blood transplantation, large and ethnically diverse inventories of cord blood are needed to permit better HLA matches and long-term survivals. In this review, a number of issues that are relevant to the history and development of an effective system for cord blood banking are discussed.


Hum Immunol


Human immunology


Rubinstein P




Has Abstract


2006-06-01 00:00:00














  • NFAT-1, Sp-1, Sp-3, and miR-21: New regulators of chemokine C receptor 7 expression in mature human dendritic cells.

    abstract::The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cells. Recent studies ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Al Akoum C,Akl I,Rouas R,Fayyad-Kazan M,Falha L,Renno T,Burny A,Lewalle P,Fayyad-Kazan H,Badran B

    更新日期:2015-05-01 00:00:00

  • CRP/CD11b ratio: a novel parameter for detecting gram-positive sepsis.

    abstract::To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gram(-)) or gram-positive (gram(+)) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing betwee...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Nuutila J,Jalava-Karvinen P,Hohenthal U,Laitinen I,Kotilainen P,Rajamäki A,Nikoskelainen J,Lilius EM

    更新日期:2009-04-01 00:00:00

  • Coexistence of an MHC chromosomal segment marked by HLA B17,BfS,C4A6,B1,DR7, and DQw9 in different ethnic groups.

    abstract::Previously we have shown that the supratype HLA B17 BfS C4A6 B1 DR7 (17 6 1 7) carrying a C4/Bgl II RFLP correlating with C4A6 coexists in whites and Thai/Chinese. Using conventional and PFGE/Southern blotting with class II, class III, and TNF probes as well as serologic DQ subtyping, we have extended these comparison...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Kay PH,Dawkins RL,Williamson J,Tokunaga K,Christiansen FT,Charoenwong P

    更新日期:1988-09-01 00:00:00

  • The origin of HLA-DR"Br": exon 2 nucleotide sequence implicates possible gene conversion of DR1 by DR4-Dw10, DR5, or DRw6-Dw18.

    abstract::The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Bidwell JL,Bidwell EA,Sansom DM,Klouda PT,Bradley BA

    更新日期:1989-11-01 00:00:00

  • Overexpression of the PDCD2-like gene results in inhibited TNF-alpha production in activated Daudi cells.

    abstract::Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 w...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Chen Q,Yan CQ,Liu FJ,Tong J,Miao SL,Chen JP

    更新日期:2008-04-01 00:00:00

  • Identification of sequence variants in the CCL3 chemokine gene family in the HapMap West African reference population.

    abstract::Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Perry RT,Nyaku MK,Aissani B,Shrestha S

    更新日期:2014-08-01 00:00:00

  • The 4H84 monoclonal antibody detecting beta2m free nonclassical HLA-G molecules also binds to free heavy chains of classical HLA class I antigens present on activated lymphocytes.

    abstract::We have found that 4H84 monoclonal antibody (mAb) used for detection of beta2m free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta2m free classical HLA class I molecules induced on the surface of acti...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Poláková K,Kuba D,Russ G

    更新日期:2004-02-01 00:00:00

  • The complexity of DRw6 and DR5 haplotypes in American blacks demonstrated by serology, cellular typing, and restriction fragment length polymorphism analysis.

    abstract::This study describes the diversity of DRw6 and DR5 haplotypes in the American black population using serology, cellular typing, and restriction fragment length polymorphism (RFLP) analysis. DRw6 (DRw13 and DRw14) and DR5 (DRw11 and DRw12) haplotypes are observed at a high frequency in this population (DRw6: 32%, DR5: ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Lee KW,Hurley CK,Hartzman R,Johnson AH

    更新日期:1990-11-01 00:00:00

  • Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with spondyloarthritis.

    abstract::To evaluate the role of tumor necrosis factor-alpha (TNF-alpha) gene as susceptibility marker for spondyloarthritis (SpA), two polymorphisms (-238 and -308 positions) were analyzed in 229 patients with SpA (113 with ankylosing spondylitis [AS], 92 with undifferentiated SpA [U-SpA], 24 with reactive arthritis), and 169...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Vargas-Alarcón G,Casasola-Vargas J,Rodríguez-Pérez JM,Huerta-Sil G,Pérez-Hernández N,Londoño J,Pacheco-Tena C,Cardiel MH,Granados J,Burgos-Vargas R

    更新日期:2006-10-01 00:00:00

  • Full-length next-generation sequencing of HLA class I and II genes in a cohort from Thailand.

    abstract::The human leukocyte antigen (HLA) genes are highly variable and are known to play an important role in disease outcomes, including infectious diseases. Prior knowledge of HLA polymorphisms in a population usually forms the basis for an effective case-control study design. As a prelude to future disease association ana...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Geretz A,Ehrenberg PK,Bouckenooghe A,Fernández Viña MA,Michael NL,Chansinghakule D,Limkittikul K,Thomas R

    更新日期:2018-11-01 00:00:00

  • Determination of Duffy genotypes in three populations of African descent using PCR and sequence-specific oligonucleotides.

    abstract::The expression of the Duffy Antigen/Receptor for Chemokines (DARC) on red blood cells (RBC) has been commonly determined using hemagglutination tests. Because the vast majority of African individuals are Duffy-negative, screening for DARC expression on RBC is a valuable tool to assess Caucasian admixture in population...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Nickel RG,Willadsen SA,Freidhoff LR,Huang SK,Caraballo L,Naidu RP,Levett P,Blumenthal M,Banks-Schlegel S,Bleecker E,Beaty T,Ober C,Barnes KC

    更新日期:1999-08-01 00:00:00

  • Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy.

    abstract::The aim of this work was to investigate the longitudinal evolution of plasmatic soluble HLA-G (sHLA-G: shed HLA-G1 plus HLA-G5) during pregnancy, and if peripheral maternal antigen presenting cells (APC) can be a source of sHLA-G. Blood samples were obtained from 45 volunteers during normal pregnancy, 8 of them monthl...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Alegre E,Díaz-Lagares A,Lemaoult J,López-Moratalla N,Carosella ED,González A

    更新日期:2007-08-01 00:00:00

  • DRB1*03 diversity and DRB3 associations in five major population groups in the United States.

    abstract::One hundred sixty-one DRB1*03 positive individuals from each of five U.S. population groups (Caucasoids, African Americans, Asians/Pacific Islanders, Hispanics, and Native Americans) were randomly selected from a database of 82,979 individuals. DRB1*03 alleles were identified by polymerase chain reaction-sequence-spec...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Tang TF,Wang J,Slack R,Lin YS,Li L,Heine U,Ng J,Hartzman RJ,Katovich Hurley C

    更新日期:2002-03-01 00:00:00

  • Effect of phorbol ester and calcium ionophore on human thymocytes.

    abstract::Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Tanahashi M,Yokoyama T,Kobayashi Y,Yamakawa Y,Maeda M,Fujii Y

    更新日期:2001-08-01 00:00:00

  • Association between LMP2/LMP7 genetic variability and the metastasis risk of ovarian cancer in Chinese women in Beijing.

    abstract::LMP2/LMP7 gene (LMP, low molecular mass protein) perform a critical role in the foreign antigen processing via the major histocompatibility complex-I (MHC-I) complex CD8(+) cytotoxic T lymphocytes (CTL) pathway. This study was designed to investigate whether the sequence variants in LMP2/LMP7 gene would increase the r...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Song L,Ma N,Han L,Yan H,Yan B,Yuan Z,Cao B

    更新日期:2014-03-01 00:00:00

  • Identification of the amino acid residues contributing to monoclonal antibody-defined DQw1 epitopes.

    abstract::The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Nordwig H,Kwok WW,Johnson JP

    更新日期:1991-06-01 00:00:00

  • The relationship between HLA class II polymorphisms and somatic deletions in testicular B cell lymphomas of Dutch patients.

    abstract::Several risk factors including immune deficiencies, infections, and autoimmune diseases have been established for non-Hodgkin's lymphoma (NHL). For diffuse large B cell lymphoma (DLBCL), the most common type of lymphoma, no risk factors have been described, which may be due to the intrinsic heterogeneity of this disor...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Riemersma SA,Jordanova ES,Haasnoot GW,Drabbels J,Schuuring E,Schreuder GM,Kluin PM

    更新日期:2006-04-01 00:00:00

  • TLR expression, phagocytosis and oxidative burst in healthy and septic newborns in response to Gram-negative and Gram-positive rods.

    abstract::The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Silveira-Lessa AL,Quinello C,Lima L,Redondo ACC,Ceccon MEJR,Carneiro-Sampaio M,Palmeira P

    更新日期:2016-10-01 00:00:00

  • Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.

    abstract::DOCK10 is a member of the dedicator of cytokinesis (DOCK) family of Rho GTPase activators preferentially expressed in lymphocytes. In this paper, we analyzed DOCK10 mRNA diversity produced because of alternative splicing. Alternative first coding exon usage led to 2 main protein-coding transcripts, DOCK10.1 and DOCK10...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Alcaraz-García MJ,Ruiz-Lafuente N,Sebastián-Ruiz S,Majado MJ,González-García C,Bernardo MV,Alvarez-López MR,Parrado A

    更新日期:2011-07-01 00:00:00

  • HLA-DR alpha, -DX alpha, and DR beta III gene association studies in DR3 individuals.

    abstract::In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Gorski J,Niven MJ,Sachs JA,Mach B,Cassell PG,Festenstein H,Awad J,Hitman GA

    更新日期:1987-12-01 00:00:00

  • Increased expressions of CD69 and HLA-DR but not of CD25 or CD71 on endometrial T lymphocytes of nonpregnant women.

    abstract::To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3-/(CD56+ or CD16+) rat...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Chen CK,Huang SC,Chen CL,Yen MR,Hsu HC,Ho HN

    更新日期:1995-03-01 00:00:00

  • TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

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    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Peluso C,Christofolini DM,Goldman CS,Mafra FA,Cavalcanti V,Barbosa CP,Bianco B

    更新日期:2013-01-01 00:00:00

  • MUC1 is a novel costimulatory molecule of human T cells and functions in an AP-1-dependent manner.

    abstract::MUC1 mucin, primarily known as an epithelial antigen, has been demonstrated to be expressed on activated human T cells. In the present study, we first examined the expression of MUC1 on different subsets of T cells (naive, effector, effector/memory). MUC1 appears to be strongly upregulated on activated CD4(+) T cells ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Konowalchuk JD,Agrawal B

    更新日期:2012-05-01 00:00:00

  • GvHD risk assessment in hematopoietic stem cell transplantation: role of cytokine gene polymorphisms and an in vitro human skin explant model.

    abstract::This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor alpha, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Dickinson AM,Cavet J,Cullup H,Wang XN,Sviland L,Middleton PG

    更新日期:2001-11-01 00:00:00

  • Mitogen-induced modulation of CD3, CD4, and CD8(1).

    abstract::It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Jason J,Inge KL

    更新日期:2000-03-01 00:00:00

  • STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behçet's disease.

    abstract::This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Hu K,Yang P,Jiang Z,Hou S,Du L,Li F

    更新日期:2010-07-01 00:00:00

  • Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28- T suppressor cells.

    abstract::Alloantigen specific CD8+CD28- T suppressor (TS) cells differ from naturally occurring CD4+CD25+ T-regulatory (natural TR) cells not only by their phenotype but also by their mechanism of action. Natural TR have been extensively studied, leading to the identification of characteristic "molecular markers" such as Forkh...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Scotto L,Naiyer AJ,Galluzzo S,Rossi P,Manavalan JS,Kim-Schulze S,Fang J,Favera RD,Cortesini R,Suciu-Foca N

    更新日期:2004-11-01 00:00:00

  • WITHDRAWN: Lack of association between the HLA-G 3'UTR 14-bp ins/del polymorphism and cancer risk: A meta-analysis of case-control study.

    abstract::This article hashas been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Human immunology

    pub_type: 撤回出版物


    authors: Li T,Huang H,Liao D,Ling H,Su B,Cai M

    更新日期:2015-11-14 00:00:00

  • Association of CD209 polymorphisms with tuberculosis in an Indonesian population.

    abstract::Tuberculosis (TB) caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. Thus far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) encoded by CD209 is the major receptor of M tuberculo...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Kobayashi K,Yuliwulandari R,Yanai H,Lien LT,Hang NT,Hijikata M,Keicho N,Tokunaga K

    更新日期:2011-09-01 00:00:00

  • Reduced frequency of two activating KIR genes in patients with sepsis.

    abstract::Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Oliveira LM,Portela P,Merzoni J,Lindenau JD,Dias FS,Beppler J,Graebin P,Alho CS,Schwartsmann G,Dal-Pizzol F,Jobim LF,Jobim M,Roesler R

    更新日期:2017-04-01 00:00:00