Gm markers in celiac disease.

abstract：:Polymorphic Alu insertions from the MHC class I region were analyzed in 215 autochthonous Basques from Guipuzcoa and Navarre provinces, with the aim of contributing new MHC Alu data in European ancestry populations. We also seek to assess both the genetic position of native Basques among worldwide samples and the effi...

journal_title：Human immunology

authors： García-Obregón S,Alfonso-Sánchez MA,Pérez-Miranda AM,Gómez-Pérez L,de Parcorbo MM,Peña JA

更新日期：2012-07-01 00:00:00

abstract：:The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...

journal_title：Human immunology

authors： Rasmussen HB,Kelly MA,Clausen J

更新日期：2001-04-01 00:00:00

abstract：:Beta-1,4-galactosyltransferase I (β-1,4-GalT-I) mediates several biological mechanisms as a key enzyme in glycobiology, but the role of β-1,4-GalT-I in immune system remains unclear. We conducted experiments to investigate whether β-1,4-GalT-I is participating in the activation of Jurkat T cell and intercellular conta...

journal_title：Human immunology

authors： Sun X,Wu Y,Wang Y,Xue Q,Cheng X,Zhang G,Zhu Y,Wang X

更新日期：2014-10-01 00:00:00

abstract：:We have studied HLA-DQ encoded antigens from HLA-DRw6 homozygous cells and analyzed the DQ region at the DNA level. HLA-DQ molecules were isolated from EBV transformed B-cell lines and analyzed for DQ alpha and DQ beta polymorphism. From the same set of cells, DNA was isolated and analyzed for RFLP. Polymorphism could...

journal_title：Human immunology

authors： Bosch ML,Fei H,Bontrop RE,Gerrets R,Tilanus MG,Termijtelen A,Giphart MJ

更新日期：1987-06-01 00:00:00

abstract：:The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...

journal_title：Human immunology

authors： Zuniga J,Romero V,Azocar J,Stern JN,Clavijo O,Almeciga I,Encinales L,Avendano A,Fridkis-Hareli M,Pandey JP,Yunis EJ

更新日期：2006-11-01 00:00:00

abstract：:There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...

journal_title：Human immunology

authors： Bangham CR,Bushell A,Wood KJ,Morris PJ

更新日期：1988-02-01 00:00:00

abstract：:We have investigated if recombinant granulocyte-macrophage colony stimulating factor (GM-CSF), alone or in concert with recombinant gamma interferon, affects the endothelial cell expression of class I major histocompatibility complex antigen. Results obtained show that the GM-CSF increases class I expression on the en...

journal_title：Human immunology

authors： Leszczynski D,Häyry P

更新日期：1990-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...

journal_title：Human immunology

authors： Zozulya AL,Wiendl H

更新日期：2008-11-01 00:00:00

abstract：:Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25- Tfh subset (CD25-CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could sup...

journal_title：Human immunology

authors： Ma X,Zha J,He J,Chen L,Huang J,Wu W,Tian P,Qian BH,Yu L,Jiang Y,Xu B

更新日期：2020-08-01 00:00:00

abstract：:Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether ...

journal_title：Human immunology

authors： Grimaldi V,Sommese L,Picascia A,Casamassimi A,Cacciatore F,Renda A,De Rosa P,Montesano ML,Sabia C,Fiorito C,De Iorio G,Napoli C

更新日期：2013-12-01 00:00:00

abstract：:Mannose-binding lectin (MBL) role in the carriage of oropharyngeal bacteria is not known. We investigated the association of smoking, MBL2 polymorphisms, and MBL concentrations with oropharyngeal carriage of respiratory bacteria in young men. Oropharyngeal specimens, MBL concentrations, and MBL2 gene polymorphisms wer...

journal_title：Human immunology

authors： Jounio U,Rantala A,Bloigu A,Juvonen R,Lajunen T,Silvennoinen-Kassinen S,Peitso A,Vainio O,Harju T,Saukkoriipi A,Leinonen M

更新日期：2010-03-01 00:00:00

abstract：:Minor lymphocyte stimulating locus (Mls) gene products in association with mouse major histocompatibility complex (MHC) class II molecules are known to determine the repertoire of T-cell receptor (TCR) in mature T cells. In order to test whether human class II molecules can present mouse Mls, HLA-DQ beta transgenic mi...

journal_title：Human immunology

authors： Zhou P,Anderson GD,Savarirayan S,Inoko H,David CS

更新日期：1991-05-01 00:00:00

abstract：:To identify the existence of antigen specific T cell responses and to follow the changes of these reactions, it is considered useful to evaluate whether certain T cells clonally accumulate in the lymphocyte population. For this purpose, we have established a novel method to analyze T cell clonality using a combination...

journal_title：Human immunology

authors： Yamamoto K,Masuko-Hongo K,Tanaka A,Kurokawa M,Hoeger T,Nishioka K,Kato T

更新日期：1996-06-01 00:00:00

abstract：:A case-control study was performed to establish a potential association of two TNF-α gene promoter SNPs (-238G>A and -308G>A) with occurrence of type 1 Diabetes mellitus (T1DM) in Croatian population (174 patients and 193 healthy controls). Genotypes (obtained by polymerase chain reaction-restriction fragment length p...

journal_title：Human immunology

authors： Korolija M,Hadžija M,Medvidović EP,Pavkovic P,Kapitanović S,Renar IP,Hadžija MP

更新日期：2010-12-01 00:00:00

abstract：:We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...

journal_title：Human immunology

authors： Levitsky V,Liu D,Southwood S,Levitskaya J,Sette A,Masucci MG

更新日期：2000-10-01 00:00:00

abstract：:Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experi...

journal_title：Human immunology

authors： Pesando JM,Nadler LM,Lazarus H,Tomaselli KJ,Stashenko P,Ritz J,Levine H,Yunis EJ,Schlossman SF

更新日期：1981-08-01 00:00:00

abstract：:This report describes a new MHC class II allele, HLA-DR beta 1*0306, discovered in a 31-year-old Norwegian male. The allele typed serologically as DRw52 (DR3) and amplified in PCR using DR52-associated group primers. This product could not be identified using established restriction digests, however. Use of Asp 700, M...

journal_title：Human immunology

authors： Fenske B,Lemieux J,Hoar D,Fitzpatrick J,Keown P

更新日期：1996-03-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

journal_title：Human immunology

authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

更新日期：2010-02-01 00:00:00

abstract：:Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...

journal_title：Human immunology

authors： Migita K,Abiru S,Maeda Y,Nakamura M,Komori A,Ito M,Fujiwara S,Yano K,Yatsuhashi H,Eguchi K,Ishibashi H

更新日期：2007-07-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptor (KIR) genes constitute a multigene family whose genomic diversity is achieved through variation in gene content and allelic polymorphism within individual KIR genes. To date, 16 KIR genes and pseudogenes have been identified, and group A and group B haplotypes are characterized...

journal_title：Human immunology

authors： Whang DH,Park H,Yoon JA,Park MH

更新日期：2005-02-01 00:00:00

abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...

journal_title：Human immunology

authors： Vidales MC,Zubillaga P,Zubillaga I,Alfonso-Sánchez MA

更新日期：2004-04-01 00:00:00

abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two E...

journal_title：Human immunology

authors： Juárez-Nicolás F,Barquera R,Martínez-Álvarez JC,Hernández-Zaragoza DI,Ortega-Yáñez A,Arrieta-Bolaños E,Clayton S,Bravo-Acevedo A,Arrazola-García MA,Immel A,Juárez-Barreto V,Benítez-Arvizu G,Vega-Martínez MDR,García-Álvarez R,

更新日期：2020-09-01 00:00:00

abstract：:LMP2/LMP7 gene (LMP, low molecular mass protein) perform a critical role in the foreign antigen processing via the major histocompatibility complex-I (MHC-I) complex CD8(+) cytotoxic T lymphocytes (CTL) pathway. This study was designed to investigate whether the sequence variants in LMP2/LMP7 gene would increase the r...

journal_title：Human immunology

authors： Song L,Ma N,Han L,Yan H,Yan B,Yuan Z,Cao B

更新日期：2014-03-01 00:00:00

abstract：:Polymorphism in the URR of the MHC class II DQA1 gene defines ten different alleles named QAP. Oligotyping for the alleles of DRB1, QAP, DQA1, and DQB1 have been performed in 210 unrelated healthy controls from Germany. Moreover, 83 HTCs from the Tenth IHWS have been tested. Four point loci haplotypes (DRB1, QAP, DQA1...

journal_title：Human immunology

authors： Haas JP,Kimura A,Andreas A,Hochberger M,Keller E,Brünnler G,Bettinotti MP,Nevinny-Stickel C,Hildebrandt B,Sierp G

更新日期：1994-01-01 00:00:00

abstract：:Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...

journal_title：Human immunology

authors： Pennesi G,Brioli G,Lulli P,Mariani B,Morellini M,Nicotra M,Trabace S

更新日期：1998-06-01 00:00:00

abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...

journal_title：Human immunology

authors： Okamoto N,Ando A,Kawai J,Yoshiwara T,Tsuji K,Inoko H

更新日期：1991-11-01 00:00:00

abstract：:Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...

journal_title：Human immunology

authors： Bennet AM,Alarcón-Riquelme M,Wiman B,de Faire U,Prokunina-Olsson L

更新日期：2006-09-01 00:00:00

abstract：:Natural antigen processing and presentation of antigen is thought to be important for the generation of a broad functional repertoire of antigen-specific T cells. In this study, the T-cell repertoire to an immunodominant human leukocyte antigen A2 (HLA-A2) binding peptide epitope of HER-2/neu, p369-377, was examined i...

journal_title：Human immunology

authors： Knutson KL,Disis ML

更新日期：2002-07-01 00:00:00

abstract：:Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate ge...

journal_title：Human immunology

authors： Idris ZM,Miswan N,Muhi J,Mohd TA,Kun JF,Noordin R

更新日期：2011-07-01 00:00:00

abstract：:In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...

journal_title：Human immunology

authors： Gorski J,Niven MJ,Sachs JA,Mach B,Cassell PG,Festenstein H,Awad J,Hitman GA

更新日期：1987-12-01 00:00:00