Ancestry markers from the human chromosome 6: Alu repeats from the MHC in autochthonous Basques.

abstract：:The genetic polymorphism of the fourth component of human complement, C4, was studied in 945 unrelated Caucasian individuals. A third allele of the C4F (Rodgers) locus, termed C4F1 was demonstrated. This allele is characterized using immunofixation electrophoresis, by the presence of an additional fast-moving anodal b...

journal_title：Human immunology

authors： O'Neill GJ,Miniter P,Pollack MS,Dupont B

更新日期：1980-07-01 00:00:00

abstract：:Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenot...

journal_title：Human immunology

authors： Schaenman JM,Rossetti M,Sidwell T,Groysberg V,Sunga G,Korin Y,Liang E,Zhou X,Abdalla B,Lum E,Bunnapradist S,Pham T,Danovitch G,Reed EF

更新日期：2018-09-01 00:00:00

abstract：:Many factors induce or enhance expression of major histocompatibility complex class I and class II molecules on various cell types. Human T lymphocytes are class II negative in the resting state but show expression of class II molecules following activation. We analyzed the modulating capacity of the lymphokines recom...

journal_title：Human immunology

authors： Diedrichs-Möhring M,Epplen JT,Schendel DJ

更新日期：1991-08-01 00:00:00

abstract：:The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...

journal_title：Human immunology

authors： Carbonara AO,DeMarchi M,van Loghem E,Ansaldi N

更新日期：1983-02-01 00:00:00

abstract：:The role of donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) in lung allograft rejection has been recognized over the past 20 years. During this time, there has been growing experience and recognition of an important role for non-HLA antibodies in lung allograft rejection. Multiple self-ant...

journal_title：Human immunology

authors： Hachem RR

更新日期：2019-08-01 00:00:00

abstract：:The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3...

journal_title：Human immunology

authors： Fainboim L,Marcos Y,Pando M,Capucchio M,Reyes GB,Galoppo C,Badía I,Remondino G,Ciocca M,Ramonet M

更新日期：1994-10-01 00:00:00

abstract：:This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...

journal_title：Human immunology

authors： Hu K,Yang P,Jiang Z,Hou S,Du L,Li F

更新日期：2010-07-01 00:00:00

abstract：:The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...

journal_title：Human immunology

authors： Klein D,Vincek V,Kasahara M,Schönbach C,O'hUigin C,Klein J

更新日期：1991-11-01 00:00:00

abstract：:During T-cell maturation, thymocytes interact with thymic stromal major histocompatibility complex (MHC) determinants and thymic hormones, and proliferate, apparently in response to MHC gene products, in the absence of antigen. The maturing thymocytes also express a series of cell surface molecules, at one stage coexp...

journal_title：Human immunology

authors： Richardson B

更新日期：1986-12-01 00:00:00

abstract：:A reliable method for high-resolution HLA-DQB1 typing using a combination of PCR- restriction fragment length polymorphism (RFLP) and PCR-single strand conformation polymorphism (SSCP) analysis is described. The second exon of the DQB1 gene was subjected to PCR using generic primers and digested with two restriction e...

journal_title：Human immunology

authors： Park MH,Whang DH,Kang SJ

更新日期：1999-09-01 00:00:00

abstract：:Dendritic cells (DCs) exposed to tumor antigens followed by treatment with T(h)1-polarizing differentiation signals have paved the way for the development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have i...

journal_title：Human immunology

authors： Holmstrøm K,Pedersen AW,Claesson MH,Zocca MB,Jensen SS

更新日期：2010-01-01 00:00:00

abstract：:Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...

journal_title：Human immunology

authors： Lanchbury JS,Sakkas LI,Marsh SG,Bodmer JG,Welsh KI,Panayi GS

更新日期：1989-09-01 00:00:00

abstract：:The pattern of lymphocyte growth from endomyocardial biopsies in 55 heart transplant recipients was shown to be correlated with the subsequent development of graft coronary disease. Persistent lymphocyte growth was observed in 39 patients, and 15 of these growers (or 41%) developed graft coronary disease. In contrast,...

journal_title：Human immunology

authors： Kaufman CL,Zeevi A,Kormos RL,Zerbe TR,Keenan RJ,Uretsky BF,Griffith BP,Hardesty RL,Duquesnoy RJ

更新日期：1990-06-01 00:00:00

abstract：:The multidrug resistance gene (mdr1) is a member of the recently described ATP binding cassette (ABC) superfamily of transporters. Family members include: (1) the cystic fibrosis transmembrane conductance regulator gene; (2) the hlyB gene of bacteria, and (3) the histocompatibility antigen modifier (HAM) gene. The lev...

journal_title：Human immunology

authors： Coon JS,Wang YZ,Bines SD,Markham PN,Chong AS,Gebel HM

更新日期：1991-10-01 00:00:00

abstract：HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...

journal_title：Human immunology

authors： Seshasubramanian V,Manisekar NK,Sathishkannan AD,Naganathan C,Narayan S

更新日期：2018-08-01 00:00:00

abstract：:Celiac disease (CD) patients are intolerant to gluten, proteins in wheat, and related cereals. Virtually all patients are human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 positive and several studies have demonstrated that CD4 T cells specific for (modified) gluten peptides bound to these HLA-DQ molecules are found in pat...

journal_title：Human immunology

authors： Stepniak D,Koning F

更新日期：2006-06-01 00:00:00

abstract：:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...

journal_title：Human immunology

authors： Gambelunghe G,Brozzetti AL,Ghaderi M,Tortoioli C,Falorni A

更新日期：2006-12-01 00:00:00

abstract：:The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analys...

journal_title：Human immunology

authors： Hurley CK,Fernandez-Vina M,Hildebrand WH,Noreen HJ,Trachtenberg E,Williams TM,Baxter-Lowe LA,Begovich AB,Petersdorf E,Selvakumar A,Stastny P,Hegland J,Hartzman RJ,Carston M,Gandham S,Kollman C,Nelson G,Spellman S,Sett

更新日期：2007-01-01 00:00:00

abstract：:Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...

journal_title：Human immunology

authors： Venet F,Schilling J,Cazalis MA,Demaret J,Poujol F,Girardot T,Rouget C,Pachot A,Lepape A,Friggeri A,Rimmelé T,Monneret G,Textoris J

更新日期：2017-01-01 00:00:00

abstract：:The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wil...

journal_title：Human immunology

authors： Viken HD,Paulsen G,Drover S,Marshall WH,Sollid LM,Gaudernack G,Thorsby E

更新日期：1995-10-01 00:00:00

abstract：:The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...

journal_title：Human immunology

authors： Georgel P

更新日期：2016-11-01 00:00:00

abstract：:CD8-positive γδ T lymphocytes (GDCD8(+)) are specifically increased in peripheral blood of Behçet's disease (BD) patients. GDCD8(+) have shown a T regulatory (Treg) function in autoimmune experimental models, human tumor infiltrates and intestinal intraepithelial lymphocytes from celiac patients. The aim of this study...

journal_title：Human immunology

authors： Clemente Ximenis A,Crespí Bestard C,Cambra Conejero A,Pallarés Ferreres L,Juan Mas A,Olea Vallejo JL,Julià Benique MR

更新日期：2016-01-01 00:00:00

abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...

journal_title：Human immunology

authors： Jackson DG,Capra JD

更新日期：1995-05-01 00:00:00

abstract：:In previous studies, major histocompatibility complex (MHC) class II DP, DQ, and DR families of genes were characterized in different primate species mostly on the basis of their second exon sequences. Resemblances were found between Old World monkey (OWM) and New World monkey (NWM) genes and were interpreted as being...

journal_title：Human immunology

authors： Kriener K,O'hUigin C,Klein J

更新日期：2001-01-01 00:00:00

abstract：:The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...

journal_title：Human immunology

authors： Zuniga J,Romero V,Azocar J,Stern JN,Clavijo O,Almeciga I,Encinales L,Avendano A,Fridkis-Hareli M,Pandey JP,Yunis EJ

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. METHODS:407...

journal_title：Human immunology

authors： Wu Z,Zheng W,Xu J,Sun F,Chen H,Li P,Chen S,Shen M,Zhang W,You X,Wu Q,Zhang F,Li Y

更新日期：2014-03-01 00:00:00

abstract：:Beta-1,4-galactosyltransferase I (β-1,4-GalT-I) mediates several biological mechanisms as a key enzyme in glycobiology, but the role of β-1,4-GalT-I in immune system remains unclear. We conducted experiments to investigate whether β-1,4-GalT-I is participating in the activation of Jurkat T cell and intercellular conta...

journal_title：Human immunology

authors： Sun X,Wu Y,Wang Y,Xue Q,Cheng X,Zhang G,Zhu Y,Wang X

更新日期：2014-10-01 00:00:00

abstract：:Antigen-selected T cell receptor (TCR) repertoires vary in complexity from very limited to extremely diverse. We have previously characterized two different CD8 T cell responses, which are restricted by the same mouse major histocompatibility complex (MHC) class I molecule, H-2 Kd. The TCR repertoire in the response a...

journal_title：Human immunology

authors： Maryanski JL,Casanova JL,Falk K,Gournier H,Jaulin C,Kourilsky P,Lemonnier FA,Lüthy R,Rammensee HG,Rötzschke O,Servis C,López JA

更新日期：1997-05-01 00:00:00

abstract：:Nucleotide sequences of alleles encoding four serologically defined splits of the HLA-A10 group, A26.1, A26.3, A26.4, and A10SA, were determined. It was confirmed that the alleles coding for A26.1 and A26.3 are identical with A*2602 and A*2601, respectively. On the other hand, alleles for A26.4 and A10SA are thus far ...

journal_title：Human immunology

authors： Ishikawa Y,Tokunaga K,Lin L,Imanishi T,Saitou S,Kimura A,Kashiwase K,Akaza T,Tadokoro K,Juji T

更新日期：1994-03-01 00:00:00

abstract：:The presence of extra HLA antigens has been demonstrated, serologically and biochemically, on the surface of lymphoblasts from a patient with acute lymphoblastic leukemia of the T-cell subtype (T-ALL). Family analysis of this patient revealed the presence of the expected antigens, plus an additional HLA antigen (A24) ...

journal_title：Human immunology

authors： Orgad S,Yang SY,Gazit E,Relias V,Zaizov R,Lyson S,Yunis EJ

更新日期：1985-03-01 00:00:00