Abstract：
:We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as efficiently as to A*1101. The A*6801:AVF complex is recognized by some A*1101-restricted AVF- specific CTL clones. However, A*6801-positive (A*6801+) EBV-transformed lymphoblastoid cell lines (LCLs) are not killed by the same effectors. Furthermore, two A*6801+ donors did not mount an AVF-specific CTL response in vitro and lacked detectable AVF-specific effectors. Thus, this epitope is either subdominant, or non-immunogenic in the context of A*6801. These characteristics correlate with low stability of this MHC:peptide complex in living cells. We also demonstrate that a highly conserved AVF-specific TCR that dominates the AVF-specific CTL response in the majority of A*1101+ individuals recognizes the A*6801 molecule as a crossreactive alloantigen. Therefore, deletion of AVF-specific T cells may contribute to the non-immunogenicity or subdominance of the peptide in A*6801+ individuals.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Levitsky V,Liu D,Southwood S,Levitskaya J,Sette A,Masucci MGdoi
10.1016/s0198-8859(00)00179-8subject
Has Abstractpub_date
2000-10-01 00:00:00pages
972-84issue
10eissn
0198-8859issn
1879-1166pii
S0198-8859(00)00179-8journal_volume
61pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00128-7
更新日期：2000-03-01 00:00:00
abstract：:Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.01.002
更新日期：2013-05-01 00:00:00
abstract：:Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed antigens. Lysis of cells sensitized with exogenously provided and endo...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90508-x
更新日期：1993-08-01 00:00:00
abstract：:Mexican Mestizos, who are the result of the admixture of Spanish, Indian, and Black genes, were analyzed for different systems. Three populations from geographical distinct areas were studied: the north (State of Nuevo Leon ), the center (State of Guanajuato), and the highlands (mainly Mexico City). Ten blood group sy...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00296-8
更新日期：2001-09-01 00:00:00
abstract：:The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90046-r
更新日期：1990-03-01 00:00:00
abstract：:TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00361-5
更新日期：2002-01-01 00:00:00
abstract：:Genes encoding for prolactin (PRL) and its receptor (PRLR) are possible candidates for multiple sclerosis (MS) and systemic lupus erythematosus (SLE) susceptibility. In fact: (1) a prolactin secretion dysfunction has been described in several autoimmune diseases including SLE and MS and their animal models; (2) both P...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(02)00804-2
更新日期：2003-02-01 00:00:00
abstract：:Antibody-mediated rejection (ABMR) is associated with poor transplant outcome. Pathogenic alloantibodies are usually directed against human leukocyte antigens (HLAs). Histological findings suggestive of ABMR usually demonstrate an anti-HLA donor-specific antibody (DSA)-mediated injury, while a small subset of patients...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2016.05.021
更新日期：2016-11-01 00:00:00
abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2003.12.014
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:The aims of this study were to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of asthma and to generate SNP to gene to pathway hypotheses. METHODS:SNPs that met a threshold of p ≤ 0.001 in a genome-wide association study (GWAS) dataset of asthma, which in...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2012.11.003
更新日期：2013-02-01 00:00:00
abstract：:This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FcγRIIa, CD209, VDR, TNF-α, IL-4, IL-6 and IFN-γ genes with symptom ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2015.09.026
更新日期：2015-10-01 00:00:00
abstract：:This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.04.007
更新日期：2010-07-01 00:00:00
abstract：:Activation of Toll-like receptors (TLR) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Upon TLR activation the release of defensins, including human beta defensin 2 (HBD-2), may occur. In this study, we explored the innate responses in patients with respiratory failure, with ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.09.009
更新日期：2011-01-01 00:00:00
abstract：:By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2008.08.279
更新日期：2008-11-01 00:00:00
abstract：:The strategy of studying the putative role of RA susceptibility genetic factors in the development of juvenile idiopathic arthritis (JIA), an autoimmune disease characterized by persistent chronic arthritis, has been proven highly successful so far. Moreover, accumulated evidence indicates that an ethnic heterogeneity...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.06.018
更新日期：2013-09-01 00:00:00
abstract：:T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(84)90060-0
更新日期：1984-12-01 00:00:00
abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haploty...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.07.280
更新日期：2020-09-01 00:00:00
abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00124-9
更新日期：1995-05-01 00:00:00
abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.10.011
更新日期：2010-02-01 00:00:00
abstract：:Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.03.018
更新日期：2006-01-01 00:00:00
abstract：:Two T4+ cloned T-lymphocyte lines specific for a papain digest product of tetanus toxin are functionally characterized. The two clones were obtained from peripheral blood mononuclear cells activated in vitro by tetanus toxoid, expanded with IL-2, and cloned in soft agar. Both clones could be induced to undergo blastog...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(87)90042-5
更新日期：1987-08-01 00:00:00
abstract：:Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of innate and adaptive immune responses. The study examined whether HLA-E and/or HLA-G polymorphisms are associated with human papillomavirus (HPV) infection susceptibility and persistence in 636 female university students in Montreal. HLA-...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.01.010
更新日期：2011-04-01 00:00:00
abstract：:The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(91)90009-x
更新日期：1991-06-01 00:00:00
abstract：:Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00287-7
更新日期：2001-09-01 00:00:00
abstract：:The difficulty of molecular typing of the HLA class I genes and the relevance of the genes of this region to disease susceptibility and transplantation have provided an impetus to develop useful typing markers. We have characterized by polymerase chain reaction analysis a new highly informative CA repeat localized app...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(96)00228-5
更新日期：1996-12-01 00:00:00
abstract：:In order to investigate the distribution of epitopes recognized by T-cell clones directed against HLA class II products, bulk primed cell populations were generated using cells matched for class I determinants but disparate for class II determinants. Cells were cloned by single cell deposition (FACS IV) or limiting di...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(86)90060-1
更新日期：1986-08-01 00:00:00
abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.01.029
更新日期：2013-05-01 00:00:00
abstract：:It has been extensively documented the role of the indirect pathway of allorecognition in allograft rejection. However, recent data demonstrate that the manipulation of this pathway could be also sufficient to promote prolongation of allograft survival. In the present study we evaluated the effect of preoperative immu...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(02)00451-2
更新日期：2002-10-01 00:00:00
abstract：:Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopo...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.12.005
更新日期：2020-01-01 00:00:00
abstract：:The compatibility of HLA-A,-B expression between mother and offspring was examined in 410 families serologically tissue typed within a single transplant lab from 1972 thru 1982. The study group included 410 mothers of 1719 children (range 2-13/mother), with 352 one-father and 58 multiple-father families There were sev...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(84)90072-7
更新日期：1984-11-01 00:00:00
