Genetic diversity of HLA system in two populations from Yucatán, Mexico: Mérida and rural Yucatán.

abstract：:The HLA-DR4 subtypes Dw14 and Dw4 are T-cell-defined allospecificities encoded by the DRB1*0404 and DRB1*0401 genes, respectively. Although these allelic subtypes differ in only two amino acids, allorecognition between Dw14 and Dw4-positive individuals is brisk. This provides an opportunity to analyze T-cell receptor ...

journal_title：Human immunology

authors： Yamanaka K,Kwok WW,Mickelson EM,Masewicz S,Nepom GT

更新日期：1992-01-01 00:00:00

abstract：:Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenot...

journal_title：Human immunology

authors： Schaenman JM,Rossetti M,Sidwell T,Groysberg V,Sunga G,Korin Y,Liang E,Zhou X,Abdalla B,Lum E,Bunnapradist S,Pham T,Danovitch G,Reed EF

更新日期：2018-09-01 00:00:00

abstract：:Preformed and de novo donor-specific HLA antibodies (DSA) have been associated with allograft dysfunction and failure. The application of solid-phase methods have increased the sensitivity and specificity of antibody detection; however the clinical significance of these DSA is under evaluation. In the present study, w...

journal_title：Human immunology

authors： Zeevi A,Lunz JG 3rd,Shapiro R,Randhawa P,Mazariegos G,Webber S,Girnita A

更新日期：2009-08-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB ...

journal_title：Human immunology

authors： Spurrell DR,Oldford SA,Frost T,Larsen B,Codner D,Edgecombe A,Drover S

更新日期：2004-12-01 00:00:00

abstract：:Using the soft-agar colony assay, we have generated three MT3-associated clones: HJ1, HJ13, and HJ39, from an MLR combination of two unrelated individuals. Another clone, HJ37, appeared to recognize a novel HLA-D determinant. PLT inhibition studies with monoclonal anti-Ia-like antibodies (Mab) were conducted on clones...

journal_title：Human immunology

authors： Zeevi A,Annen K,Scheffel C,Duquesnoy RJ

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of generalized aggressive periodontitis (AgP) and chronic periodontitis (CP). The objective of the present study was to evaluate the association of four TNF-alpha gene polymorphisms (-1031T/C, -857C/T, -308G/A and -238G/A) with ...

journal_title：Human immunology

authors： Yang W,Jia Y,Wu H

更新日期：2013-12-01 00:00:00

abstract：:HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...

journal_title：Human immunology

authors： Faner R,Casamitjana N,Coll J,Caro P,Pujol-Borrell R,Palou E,Juan M

更新日期：2006-04-01 00:00:00

abstract：:The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...

journal_title：Human immunology

authors： Klein D,Vincek V,Kasahara M,Schönbach C,O'hUigin C,Klein J

更新日期：1991-11-01 00:00:00

abstract：HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...

journal_title：Human immunology

authors： Seshasubramanian V,Manisekar NK,Sathishkannan AD,Naganathan C,Narayan S

更新日期：2018-08-01 00:00:00

abstract：:Cumulative evidence indicates that the human interleukin-4 receptor alpha chain gene (IL-4Ralpha, CD124) is highly polymorphic in contrast to other cytokine receptor genes. Our group recently identified the IL-4Ralpha variant R551 as being strongly associated with decreased kidney allograft survival. Due to the key im...

journal_title：Human immunology

authors： Hackstein H,Hofmann H,Bohnert A,Bein G

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. METHODS:407...

journal_title：Human immunology

authors： Wu Z,Zheng W,Xu J,Sun F,Chen H,Li P,Chen S,Shen M,Zhang W,You X,Wu Q,Zhang F,Li Y

更新日期：2014-03-01 00:00:00

abstract：:The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...

journal_title：Human immunology

authors： Sinkovits G,Szilágyi Á,Farkas P,Inotai D,Szilvási A,Tordai A,Rázsó K,Réti M,Prohászka Z

更新日期：2017-02-01 00:00:00

abstract：:HLA-DQ molecules were isolated from DRw9-homozygous and DR4-homozygous cell lines by using a monoclonal antibody HU-18, which recognizes class II molecules carrying the conventional DQw3 determinant. The partial N-terminal sequence analysis of the DQw3 molecules revealed that they have sequences homologous to those of...

journal_title：Human immunology

authors： Obata F,Endo T,Yoshii M,Otani F,Igarashi M,Takenouchi T,Ikeda H,Ogasawara K,Kasahara M,Wakisaka A

更新日期：1985-09-01 00:00:00

abstract：:Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...

journal_title：Human immunology

authors： Mizuki N,Yabuki K,Ota M,Verity D,Katsuyama Y,Ando H,Onari K,Goto K,Imagawa Y,Mandanat W,Fayyad F,Stanford M,Ohno S,Inoko H

更新日期：2001-02-01 00:00:00

abstract：:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...

journal_title：Human immunology

authors： Kitaya K,Yasuo T

更新日期：2010-02-01 00:00:00

abstract：:Graves disease (GD) is an autoimmune thyroid disease and is associated with human leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians. However, the association of HLA with GD is less clear-cut in East Asian populations. We analyzed HLA-DRB1 and -DQB1 associations with GD in 198 Korean patients compared with 200 he...

journal_title：Human immunology

authors： Park MH,Park YJ,Song EY,Park H,Kim TY,Park DJ,Park KS,Cho BY

更新日期：2005-06-01 00:00:00

abstract：:Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (...

journal_title：Human immunology

authors： Falleti E,Fabris C,Vandelli C,Colletta C,Cussigh A,Smirne C,Fontanini E,Cmet S,Minisini R,Bitetto D,Toniutto P,Pirisi M

更新日期：2010-10-01 00:00:00

abstract：:We have found that 4H84 monoclonal antibody (mAb) used for detection of beta2m free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta2m free classical HLA class I molecules induced on the surface of acti...

journal_title：Human immunology

authors： Poláková K,Kuba D,Russ G

更新日期：2004-02-01 00:00:00

abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...

journal_title：Human immunology

authors： Carrier CM,Mollen N,Rothman WC,Rodriguez de Cordoba S,Rey-Campos J,Ginsberg-Fellner F,Carpenter C,Rubinstein P

更新日期：1989-01-01 00:00:00

abstract：:Nucleotide sequences of alleles encoding four serologically defined splits of the HLA-A10 group, A26.1, A26.3, A26.4, and A10SA, were determined. It was confirmed that the alleles coding for A26.1 and A26.3 are identical with A*2602 and A*2601, respectively. On the other hand, alleles for A26.4 and A10SA are thus far ...

journal_title：Human immunology

authors： Ishikawa Y,Tokunaga K,Lin L,Imanishi T,Saitou S,Kimura A,Kashiwase K,Akaza T,Tadokoro K,Juji T

更新日期：1994-03-01 00:00:00

abstract：:Dendritic cells play an important role in the initiation of immune reactions. Due to their high capacity to prime T-cell responses, the activation of dendritic cells must be tightly controlled. Because Interleukin-1β (IL-1β) is a key player in autoinflammatory diseases, we compared the ability of IL-1β to activate hum...

journal_title：Human immunology

authors： Michelini S,Sarajlic M,Duschl A,Horejs-Hoeck J

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). METHODS:We performed a meta-analysis on the association between the four gene polymorphisms and RA. RESULTS:Nineteen studies ...

journal_title：Human immunology

authors： Lee YH,Bae SC,Song GG

更新日期：2015-03-01 00:00:00

abstract：:Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...

journal_title：Human immunology

authors： Han M,Fallena M,Guo Y,Stastny P

更新日期：2007-06-01 00:00:00

abstract：:The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms a...

journal_title：Human immunology

authors： Lemos MC,Fagulha A,Coutinho E,Gomes L,Bastos M,Barros L,Carrilho F,Geraldes E,Regateiro FJ,Carvalheiro M

更新日期：2008-02-01 00:00:00

abstract：:Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...

journal_title：Human immunology

authors： Taylor M,Bergemann TL,Hussain A,Thompson PD,Spector L

更新日期：2011-10-01 00:00:00

abstract：:The recognition of minor alloantigens by cytotoxic T lymphocytes (CTL) serves as a model for the recognition of tumor and viral antigens. Progress in this area has been limited, however, since CTL recognize minor alloantigens only in association with self-class I antigens. Thus, experiments designed to study minor all...

journal_title：Human immunology

authors： Zier KS,Volsky DJ,Sinangil F

更新日期：1987-05-01 00:00:00

abstract：:HLA-G molecule has considerable impact in various clinical fields, therefore many studies attempted to predict its expression based on HLA-G genotype. These studies have focused on polymorphisms in either the coding region or in one of the two untranslated regions (UTR) of the gene. The aim of our study was to determi...

journal_title：Human immunology

authors： Di Cristofaro J,El Moujally D,Agnel A,Mazières S,Cortey M,Basire A,Chiaroni J,Picard C

更新日期：2013-02-01 00:00:00

abstract：:Felty's syndrome (FS) is a rare complication of rheumatoid arthritis (RA) previously shown to be strongly associated with HLA-DR4 and less significantly with HLA-DQw7. To map more precisely the HLA locus responsible for susceptibility to FS, we have examined HLA-DR4 and DQ beta-chain polymorphisms in FS patients and c...

journal_title：Human immunology

authors： Lanchbury JS,Jaeger EE,Sansom DM,Hall MA,Wordsworth P,Stedeford J,Bell JI,Panayi GS

更新日期：1991-09-01 00:00:00

abstract：:Polymorphism in the URR of the MHC class II DQA1 gene defines ten different alleles named QAP. Oligotyping for the alleles of DRB1, QAP, DQA1, and DQB1 have been performed in 210 unrelated healthy controls from Germany. Moreover, 83 HTCs from the Tenth IHWS have been tested. Four point loci haplotypes (DRB1, QAP, DQA1...

journal_title：Human immunology

authors： Haas JP,Kimura A,Andreas A,Hochberger M,Keller E,Brünnler G,Bettinotti MP,Nevinny-Stickel C,Hildebrandt B,Sierp G

更新日期：1994-01-01 00:00:00

abstract：:Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...

journal_title：Human immunology

authors： Tanahashi M,Yokoyama T,Kobayashi Y,Yamakawa Y,Maeda M,Fujii Y

更新日期：2001-08-01 00:00:00