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Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population.

Abstract：

:The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207 patients with type 1 diabetes and 249 controls for the FokI T>C (rs10735810), BsmI A>G (rs1544410), ApaI G>T (rs7975232), and TaqI C>T (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis. The distribution of VDR genotype, allele, and haplotype frequencies did not differ significantly between patients and controls. These data suggest that the single nucleotide polymorphisms of the VDR gene are unlikely to contribute significantly to type 1 diabetes susceptibility in the Portuguese population.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Lemos MC,Fagulha A,Coutinho E,Gomes L,Bastos M,Barros L,Carrilho F,Geraldes E,Regateiro FJ,Carvalheiro M

doi

10.1016/j.humimm.2008.01.008

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

134-8

issue

2

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(08)00017-7

journal_volume

69

pub_type

杂志文章

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