Abstract：
:Patterns of BglII, MspI, and TaqI DP alpha and DP beta hybridizing restriction fragment length polymorphisms are compared with primed lymphocyte typing--determined specificities in 28 10th International Histocompatibility Workshop core cell lines. Correlation of specific RFLP patterns with most recognized DP types is confirmed, although the RFLPs do not distinguish DPw3 from DPw6. Analysis of DP-region nucleotide sequence data shows that the observed RFLPs are those expected to hybridize to the DP alpha and beta probes and are thus not due to cross-hybridization to other genes. The distribution of RFLPs in Chinese, Micronesian, South Indian, and white Australian populations is described. The most frequent DP specificity in Chinese is DPw5. In the other populations DPw4 is the most common specificity, although DPw5 is also relatively common in Micronesians. Four new DP alpha RFLP patterns and three new DP beta patterns are described. There are also numerous unusual combinations of DP alpha and DP beta alleles particularly in the South Indian population.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Easteal S,Voorhoeve AH,Zimmet P,Serjeantson SWdoi
10.1016/0198-8859(89)90080-3subject
Has Abstractpub_date
1989-07-01 00:00:00pages
169-79issue
3eissn
0198-8859issn
1879-1166pii
0198-8859(89)90080-3journal_volume
25pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.02.001
更新日期：2007-06-01 00:00:00
abstract：:Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.04.006
更新日期：2011-08-01 00:00:00
abstract：:In previous studies, major histocompatibility complex (MHC) class II DP, DQ, and DR families of genes were characterized in different primate species mostly on the basis of their second exon sequences. Resemblances were found between Old World monkey (OWM) and New World monkey (NWM) genes and were interpreted as being...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(00)00233-0
更新日期：2001-01-01 00:00:00
abstract：:Antibody-mediated rejection (ABMR) is associated with poor transplant outcome. Pathogenic alloantibodies are usually directed against human leukocyte antigens (HLAs). Histological findings suggestive of ABMR usually demonstrate an anti-HLA donor-specific antibody (DSA)-mediated injury, while a small subset of patients...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2016.05.021
更新日期：2016-11-01 00:00:00
abstract：:Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.04.003
更新日期：2005-07-01 00:00:00
abstract：:Allogeneic hematopoietic stem cell transplantation (alloHCT) is the definitive therapy for numerous otherwise incurable hematologic malignancies and non-malignant diseases. The genetic disparity between donor and recipient both underpins therapeutic effects and confers donor immune system-mediated damage in the recipi...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2019.03.003
更新日期：2019-06-01 00:00:00
abstract：:Cumulative evidence indicates that the human interleukin-4 receptor alpha chain gene (IL-4Ralpha, CD124) is highly polymorphic in contrast to other cytokine receptor genes. Our group recently identified the IL-4Ralpha variant R551 as being strongly associated with decreased kidney allograft survival. Due to the key im...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00102-0
更新日期：1999-11-01 00:00:00
abstract：:Phagocytosis and catabolism of sheep red blood cells by human peripheral blood phagocytes were studied in 100 normal caucasoid subjects (44 males and 56 females). Both phenomena are highly reproducible, and their indices seem to be biological constants. There is no correlation between these two indices and the indices...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(82)90045-3
更新日期：1982-02-01 00:00:00
abstract：:The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rej...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(98)00059-7
更新日期：1998-09-01 00:00:00
abstract：:HLA-B703 (BPOT) is a B7-like antigen segregating within families. To determine the complete B*0703 nucleotide sequence, HLA-ABC-cDNAs derived from the EBV cell line POT71 have been cloned. Four B*0703-positive clones were sequenced to obtain an accurate consensus sequence. With respect to the isoelectric focusing-iden...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90533-7
更新日期：1993-10-01 00:00:00
abstract：:Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.03.018
更新日期：2006-01-01 00:00:00
abstract：:By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2008.08.279
更新日期：2008-11-01 00:00:00
abstract：:To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICA5 was significantly increased in the T1D patient grou...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.02.032
更新日期：2006-01-01 00:00:00
abstract：:Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.01.012
更新日期：2010-04-01 00:00:00
abstract：:Neem leaf preparation (NLP) was found to activate natural killer (NK) cells (CD56(+)CD3(-)) to enhance their cytotoxic ability to tumor cells and stimulate the release of interleukin-12 (IL-12) from macrophages from healthy individuals and head-and-neck squamous cell carcinoma patients. NLP upregulated cytotoxic (CD16...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.08.002
更新日期：2007-10-01 00:00:00
abstract：:Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infections. In humans, MUC1 is highly polymorphic, predominantly due to the presence of a variable number tandem repeat (VNTR) region in the extracellular domain that results in MUC1 molecules of...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.06.001
更新日期：2019-10-01 00:00:00
abstract：:Recent studies from this laboratory reported the mapping of the full profile of T-cell allorecognition regions of HLA-DR2 beta subunit. The results indicated the presence of an allodeterminant within DR2 beta regions 141-156. In another study, we have shown that this allodeterminant is one of five regions of structura...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(92)90082-x
更新日期：1992-05-01 00:00:00
abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2003.12.014
更新日期：2004-04-01 00:00:00
abstract：:Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(99)00151-2
更新日期：2000-02-01 00:00:00
abstract：:HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...
journal_title：Human immunology
pub_type： 多中心研究
doi：10.1016/s0198-8859(01)00305-6
更新日期：2001-10-01 00:00:00
abstract：HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.05.005
更新日期：2018-08-01 00:00:00
abstract：:In our earlier studies, single nucleotide polymorphisms (SNPs) associated with anti-inflammatory cytokines were found to influence risk for breast cancer in western Indian women. Analysis of Interleukin 6 (IL-6) -174G>C polymorphism in this cohort (patients = 182; controls = 236) suggested a protective role for IL-6 -...
journal_title：Human immunology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.humimm.2014.06.018
更新日期：2014-08-01 00:00:00
abstract：:Of 188 cases of Kaposi's sarcoma arising de novo after transplantation, HLA-A, -B typing was available for 135 and HLA-DR typing available for 67. Compared to the reported HLA phenotype frequencies of renal transplant recipients in the Southeast Organ Procurement Foundation (SEOPF), there is a significantly decreased ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90069-2
更新日期：1990-09-01 00:00:00
abstract：:MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90552-c
更新日期：1993-12-01 00:00:00
abstract：:Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.02.005
更新日期：2017-04-01 00:00:00
abstract：:Pronase treatment is used in the flow cytometry crossmatch (FCXM) to prevent nonspecific antibody binding on B cells. However, we have observed unexpected positive results with pronase-treated T cells in human immunodeficiency virus (HIV)-infected patients. In this study, 25 HIV-infected patients without HLA antibodie...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.04.014
更新日期：2016-06-01 00:00:00
abstract：:Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obta...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.02.005
更新日期：2019-07-01 00:00:00
abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00124-9
更新日期：1995-05-01 00:00:00
abstract：:"Those who do not know the past are destined to repeat it". The current system for the allocation of deceased donor kidneys that was implemented in December 2014 (termed the kidney allocation system (KAS)) was the culmination of a decade-long process. Thus, many people involved in transplantation today may not be awar...
journal_title：Human immunology
pub_type： 历史文章,杂志文章
doi：10.1016/j.humimm.2016.08.008
更新日期：2017-01-01 00:00:00
abstract：:The aim of this study was to analyze the relationship between the IFNG +874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.03.009
更新日期：2018-06-01 00:00:00
