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The 4H84 monoclonal antibody detecting beta2m free nonclassical HLA-G molecules also binds to free heavy chains of classical HLA class I antigens present on activated lymphocytes.

Abstract：

:We have found that 4H84 monoclonal antibody (mAb) used for detection of beta2m free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta2m free classical HLA class I molecules induced on the surface of activated lymphocytes not expressing HLA-G also bind 4H84 mAb. These results demonstrate that 4H84 mAb should be used for detection of HLA-G in cells and tissues with backing by other HLA-G specific mAbs.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Poláková K,Kuba D,Russ G

doi

10.1016/j.humimm.2003.10.005

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

157-62

issue

2

eissn

0198-8859

issn

1879-1166

pii

S0198885903006256

journal_volume

65

pub_type

杂志文章

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