Abstract:
:HLA-G molecule has considerable impact in various clinical fields, therefore many studies attempted to predict its expression based on HLA-G genotype. These studies have focused on polymorphisms in either the coding region or in one of the two untranslated regions (UTR) of the gene. The aim of our study was to determine if HLA-G haplotype defined based on SNPs 5' and 3'UTR could be used to predict soluble HLA-G expression in unstimulated individuals. Our findings showed that HLA-G haplotype structure was well conserved between distant populations and that the defined haplotypes were correlated with high, normal and low HLA-G soluble secretors. In conclusion, we showed that this genotyping strategy based on the use of a few selected SNPs rather than isolated SNP analysis allows reliable HLA-G expression in all populations. This strategy could be useful in a number of clinical settings, e.g., predicting graft compatibility immunogenetic laboratories.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Di Cristofaro J,El Moujally D,Agnel A,Mazières S,Cortey M,Basire A,Chiaroni J,Picard Cdoi
10.1016/j.humimm.2012.10.027subject
Has Abstractpub_date
2013-02-01 00:00:00pages
203-6issue
2eissn
0198-8859issn
1879-1166pii
S0198-8859(12)00598-8journal_volume
74pub_type
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