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Complete nucleotide sequence of HLA-B*0703, a B7 variant (BPOT).

Abstract：

:HLA-B703 (BPOT) is a B7-like antigen segregating within families. To determine the complete B*0703 nucleotide sequence, HLA-ABC-cDNAs derived from the EBV cell line POT71 have been cloned. Four B*0703-positive clones were sequenced to obtain an accurate consensus sequence. With respect to the isoelectric focusing-identical HLA-B*0702 allelic product, HLA-B*0703 differed only in a cluster of four nucleotide substitutions in exon 2 and a single (silent) nucleotide substitution in exon 3. The resulting amino acid substitutions in the alpha 1 domain of B703 at residues 69 (Ala-->Thr), 70 (Gln-->Asn), and 71 (Ala-->Thr) probably have their origin in a segmental exchange between B7 and other B alleles.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Bergmans AM,Tijssen H,Lardy N,Reekers P

doi

10.1016/0198-8859(93)90533-7

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

159-62

issue

2

eissn

0198-8859

issn

1879-1166

pii

0198-8859(93)90533-7

journal_volume

38

pub_type

杂志文章

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