Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expressi

abstract：:HLA analysis of the family of a renal transplant patient revealed an extremely rare condition. On repeated typings the only demonstrable HLA antigens shown in the propositus were from the maternal haplotype, HLA-A11,-B46,-CW1,-DR14,-DQ1. No paternal antigens could be demonstrated either by serologic or by DNA-typing m...

journal_title：Human immunology

authors： van den Berg-Loonen EM,Savelkoul P,van Hooff H,van Eede P,Riesewijk A,Geraedts J

更新日期：1996-01-01 00:00:00

abstract：:Class I molecules of the major histocompatibility complex bind peptides derived from cytosolic proteins and display them on the cell surface. This function alerts cytotoxic T cells to the presence of intracellular pathogens. Class I molecule assembly requires the association of the heavy chain with beta 2-microglobuli...

journal_title：Human immunology

authors： Bresnahan PA,Barber LD,Brodsky FM

更新日期：1997-04-01 00:00:00

abstract：:Recent epidemiologic and phylogenetic analyses suggest that in the human population human immunodeficiency virus (HIV-1) is a relatively new pathogen that arose by zoonotic transmission from chimpanzees. In humans the morbidity and mortality figures due to HIV infection are extremely high. In a very small percentage o...

journal_title：Human immunology

authors： Balla-Jhagjhoorsingh SS,Verschoor EJ,de Groot N,Teeuwsen VJ,Bontrop RE,Heeney JL

更新日期：2003-07-01 00:00:00

abstract：:Identification of mycobacterial antigens that are recognized by CD4+ Th1 cells in HLA-nonrestricted manner or in association with multiple allelic products is required to develop universally effective vaccines against mycobacterial diseases. Our studies in this direction have shown that several recombinant mycobacteri...

journal_title：Human immunology

authors： Mustafa AS

更新日期：2000-02-01 00:00:00

abstract：:The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We ...

journal_title：Human immunology

authors： Zhang L,Lu Q,Yang Z,Wang X,Cai L,Liu X,Liao R,Yang X,Chen Y,Yang Z

更新日期：2014-12-01 00:00:00

abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

journal_title：Human immunology

authors： Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

更新日期：1999-01-01 00:00:00

abstract：:Development of tolerance protocols requires assays or biomarkers that distinguish tolerant recipients from non-tolerant ones to be established. In addition, a thorough understanding of the plausible mechanisms associated with clinical transplant tolerance is necessary to take the field forward. Unlike the majority of ...

journal_title：Human immunology

authors： Mathew JM,Ansari MJ,Gallon L,Leventhal JR

更新日期：2018-05-01 00:00:00

abstract：:The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to inve...

journal_title：Human immunology

authors： de Lima RE,de Holanda Martins CM,do Carmo RF,Aroucha DCBL,Pereira LMMB,Vasconcelos LRS,Moura P

更新日期：2018-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver. We evaluated the association of alleles and genotypes of polymorphisms of IL-18 (-607C/A and -137G/C), IFN-γ (+874T/A) and TNF-α (-238G/A and -308G/A) with the risk and severity of HCC. One-hundred-and-twelve patients with HCC and 202 healthy co...

journal_title：Human immunology

authors： Teixeira AC,Mendes CT Jr,Marano LA,Deghaide NH,Secaf M,Elias J Jr,Muglia V,Donadi EA,Martinelli AL

更新日期：2013-08-01 00:00:00

abstract：:CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN...

journal_title：Human immunology

authors： Chen Q,Yuan S,Sun H,Peng L

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of generalized aggressive periodontitis (AgP) and chronic periodontitis (CP). The objective of the present study was to evaluate the association of four TNF-alpha gene polymorphisms (-1031T/C, -857C/T, -308G/A and -238G/A) with ...

journal_title：Human immunology

authors： Yang W,Jia Y,Wu H

更新日期：2013-12-01 00:00:00

abstract：:Many factors induce or enhance expression of major histocompatibility complex class I and class II molecules on various cell types. Human T lymphocytes are class II negative in the resting state but show expression of class II molecules following activation. We analyzed the modulating capacity of the lymphokines recom...

journal_title：Human immunology

authors： Diedrichs-Möhring M,Epplen JT,Schendel DJ

更新日期：1991-08-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptor (KIR) genes constitute a multigene family whose genomic diversity is achieved through variation in gene content and allelic polymorphism within individual KIR genes. To date, 16 KIR genes and pseudogenes have been identified, and group A and group B haplotypes are characterized...

journal_title：Human immunology

authors： Whang DH,Park H,Yoon JA,Park MH

更新日期：2005-02-01 00:00:00

abstract：:The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. How...

journal_title：Human immunology

authors： Lundberg K,Greiff L,Borrebaeck CA,Lindstedt M

更新日期：2010-10-01 00:00:00

abstract：:Antigen-selected T cell receptor (TCR) repertoires vary in complexity from very limited to extremely diverse. We have previously characterized two different CD8 T cell responses, which are restricted by the same mouse major histocompatibility complex (MHC) class I molecule, H-2 Kd. The TCR repertoire in the response a...

journal_title：Human immunology

authors： Maryanski JL,Casanova JL,Falk K,Gournier H,Jaulin C,Kourilsky P,Lemonnier FA,Lüthy R,Rammensee HG,Rötzschke O,Servis C,López JA

更新日期：1997-05-01 00:00:00

abstract：:From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from b...

journal_title：Human immunology

authors： Ouwehand AJ,Vaessen LM,Baan CC,Jutte NH,Balk AH,Essed CE,Bos E,Claas FH,Weimar W

更新日期：1991-01-01 00:00:00

abstract：:A comprehensive system for genetic typing of the HLA class I A locus is described, based on PCR amplification and typing with nonradioactively labeled SSO probes. Exons 1-3 of the A locus are amplified and typing is performed with a set of 30 nonradioactively labeled oligonucleotide probes. This system resolves 34 of ...

journal_title：Human immunology

authors： Allen M,Liu L,Gyllensten U

更新日期：1994-05-01 00:00:00

abstract：:Recent studies from this laboratory reported the mapping of the full profile of T-cell allorecognition regions of HLA-DR2 beta subunit. The results indicated the presence of an allodeterminant within DR2 beta regions 141-156. In another study, we have shown that this allodeterminant is one of five regions of structura...

journal_title：Human immunology

authors： Atassi H,Atassi MZ

更新日期：1992-05-01 00:00:00

abstract：:The aim of this study was to investigate the possible association between the inducible nitric oxide synthase (NOS2) gene promoter polymorphism, CCTTTn microsatellite, with celiac disease susceptibility. We carried out a familial study in which 53 Spanish families were genotyped by a polymerase chain reaction (PCR)-ba...

journal_title：Human immunology

authors： Rueda B,López-Nevot MA,Pascual M,Ortega E,Maldonado J,López ML,Koeleman BP,Martín J

更新日期：2002-11-01 00:00:00

abstract：:Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...

journal_title：Human immunology

authors： Taylor M,Bergemann TL,Hussain A,Thompson PD,Spector L

更新日期：2011-10-01 00:00:00

abstract：:Serological identification of a new HLA-Bw16 subtype, B39B, was made by the analysis of reaction patterns of many alloantisera and one monoclonal antibody. The B39B pattern of reactivity was shown to be distinct from HLA-Bw38, Bw39, and 8w57. Cytotoxicity testing before and after absorption suggests that the B39B spec...

journal_title：Human immunology

authors： Williams E,Alonso A,Doyle P,Okoye R,Ollier W,Festenstein H

更新日期：1985-09-01 00:00:00

abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

journal_title：Human immunology

authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

更新日期：2003-05-01 00:00:00

abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...

journal_title：Human immunology

authors： Ben-Ali M,Barreiro LB,Chabbou A,Haltiti R,Braham E,Neyrolles O,Dellagi K,Gicquel B,Quintana-Murci L,Barbouche MR

更新日期：2007-11-01 00:00:00

abstract：:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...

journal_title：Human immunology

authors： Nunez G,Stastny P

更新日期：1983-01-01 00:00:00

abstract：:Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...

journal_title：Human immunology

authors： Hetrick SJ,Schillinger KP,Zachary AA,Jackson AM

更新日期：2011-04-01 00:00:00

abstract：:CD4+ T cells were cultured from posttransplant cardiac biopsies placed on irradiated feeder cells of autologous cloned donor major histocompatibility complex class II-specific T-cell lines cultured and grown from previous biopsies. Fourteen of the CD4+ T-cell cultures were expanded and cloned using the same feeder cel...

journal_title：Human immunology

authors： Wang YC,Kanter K,Lattouf O,Rodey GE,Sell KW,Ansari AA

更新日期：1990-06-01 00:00:00

abstract：:A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of t...

journal_title：Human immunology

authors： Harari A,Zimmerli SC,Pantaleo G

更新日期：2004-05-01 00:00:00

abstract：:The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms a...

journal_title：Human immunology

authors： Lemos MC,Fagulha A,Coutinho E,Gomes L,Bastos M,Barros L,Carrilho F,Geraldes E,Regateiro FJ,Carvalheiro M

更新日期：2008-02-01 00:00:00

abstract：:The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...

journal_title：Human immunology

authors： Sinkovits G,Szilágyi Á,Farkas P,Inotai D,Szilvási A,Tordai A,Rázsó K,Réti M,Prohászka Z

更新日期：2017-02-01 00:00:00

abstract：:Despite the reports of dysfunction of the lytic abilities of CD8(+) T cells during human immunodeficiency virus-1 (HIV-1) disease progression, the effects of infection on the noncytolytic functions of CD8(+) T cells have not been well characterized to date. We examined the effect of HIV-1 infection on the cytokine and...

journal_title：Human immunology

authors： Gulzar N,Diker B,Balasubramanian S,Jiang JQ,Copeland KF

更新日期：2011-11-01 00:00:00