Abstract:
:The aim of this study was to assess the possible association of the functional (GT)(n) microsatellite polymorphism in the FOXP3 gene with predisposition to several autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn's disease, and celiac disease. We analyzed a case-control cohort composed of 231 SLE patients, 293 RA patients, 528 inflammatory bowel disease (354 Crohn's disease patients and 260 UC patients) patients, 103 celiac disease patients, and 274 healthy controls ethnically matched. Genotyping of (GT)(n) microsatellite was performed by polymerase chain reaction (PCR)-based method combined with fluorescent technology. We found no evidence for association of this polymorphism between controls and these autoimmune disease patients. Additionally, no differences in the genotype and allele distribution were found when patients were stratified according to clinical manifestation. The (GT)(n) microsatellite of the FOXP3 gene may not play a relevant role in the susceptibility to SLE, RA, inflammatory bowel disease, and celiac disease in our population.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Sánchez E,Rueda B,Orozco G,Oliver J,Vilchez JR,Paco L,López-Nevot MA,Callejas JL,Sabio JM,Gómez-Garcia M,Nieto A,Delgado M,Martín Jdoi
10.1016/j.humimm.2005.06.001subject
Has Abstractpub_date
2005-08-01 00:00:00pages
869-73issue
8eissn
0198-8859issn
1879-1166pii
S0198-8859(05)00115-1journal_volume
66pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::The aim of this study was to investigate the possible association between the inducible nitric oxide synthase (NOS2) gene promoter polymorphism, CCTTTn microsatellite, with celiac disease susceptibility. We carried out a familial study in which 53 Spanish families were genotyped by a polymerase chain reaction (PCR)-ba...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00443-3
更新日期:2002-11-01 00:00:00
abstract::Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.014
更新日期:2008-11-01 00:00:00
abstract::Besides central tolerance peripheral tolerance is an important mechanism to avoid development of autoimmunity. Naturally occurring thymic-derived regulatory T cells (nTreg) mediate peripheral tolerance by suppressing autoreactive T cells clones having escaped thymic deletional control. This implies that nTreg have the...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2015.06.015
更新日期:2015-08-01 00:00:00
abstract::Mexican Mestizos, who are the result of the admixture of Spanish, Indian, and Black genes, were analyzed for different systems. Three populations from geographical distinct areas were studied: the north (State of Nuevo Leon ), the center (State of Guanajuato), and the highlands (mainly Mexico City). Ten blood group sy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00296-8
更新日期:2001-09-01 00:00:00
abstract::Hepatitis E virus (HEV) causes high mortality among pregnant women. Pathogenesis of HEV, especially during pregnancy, is poorly understood. Our aim was to assess the role of Toll-like-receptors (TLRs) in hepatitis E patients with pregnancy (Antenatal care, ANC) or without pregnancy (non-ANC). The patient categories in...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2014.10.011
更新日期:2014-12-01 00:00:00
abstract::The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2003.12.013
更新日期:2004-03-01 00:00:00
abstract::Monoclonal antibodies have played an important role in studying the biochemistry of the HLA-Class I molecules. Some murine anti-HLA mAbs can identify configurations of HLA epitopes that have never been reported in human allosera. One of these configurations is identified by an IgM mAb designated as: BHA-1441. This ant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00254-3
更新日期:2001-07-01 00:00:00
abstract::Cytomegalovirus (CMV) is a well-known cause of disease occurring after bone marrow transplantation (BMT). The manifestations of CMV range from asymptomatic infection, defined as active CMV replication in the blood in the absence of clinical manifestations or organ failure abnormalities, to CMV disease, characterized b...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2004.02.013
更新日期:2004-05-01 00:00:00
abstract::Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.01.005
更新日期:2011-04-01 00:00:00
abstract::Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90033-5
更新日期:1989-09-01 00:00:00
abstract::HLA-B703 (BPOT) is a B7-like antigen segregating within families. To determine the complete B*0703 nucleotide sequence, HLA-ABC-cDNAs derived from the EBV cell line POT71 have been cloned. Four B*0703-positive clones were sequenced to obtain an accurate consensus sequence. With respect to the isoelectric focusing-iden...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90533-7
更新日期:1993-10-01 00:00:00
abstract::NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit a considerable degree of genetic polymorphism, and although the functional significance of such allelic variation remains unclear, genetic vari...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.018
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.10.014
更新日期:2017-02-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infection has been associated with enhanced expression of HLA antigens on the endothelium and with cellular infiltrates within the graft following human organ transplantation. We investigated the interactions between human cytomegalovirus-infected cultured endothelial cells and cocultured ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(95)00095-x
更新日期:1995-11-01 00:00:00
abstract::Monoclonal antibodies (DA-2 and CA-2) and xenoantisera (rabbit anti-human, p23,30) specific for HLA-DR framework determinants were added to primary and secondary mixed lymphocyte cultures. Although such antisera were shown to inhibit primary MLC, primed lymphocytes were much less sensitive to the blocking effects of t...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90050-1
更新日期:1981-10-01 00:00:00
abstract::Development of tolerance protocols requires assays or biomarkers that distinguish tolerant recipients from non-tolerant ones to be established. In addition, a thorough understanding of the plausible mechanisms associated with clinical transplant tolerance is necessary to take the field forward. Unlike the majority of ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.009
更新日期:2018-05-01 00:00:00
abstract::Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2014.06.009
更新日期:2014-08-01 00:00:00
abstract::The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(83)90069-1
更新日期:1983-01-01 00:00:00
abstract::Toll-like receptors (TLRs) are important in the initiation of immune responses in both health and disease. How TLR activity alters with age, gender, and also with immunosuppressive agents is still largely unexplored. We studied TLR activity in 49 healthy individuals as well as in 26 patients receiving immunosuppressiv...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.01.018
更新日期:2010-04-01 00:00:00
abstract::The HLA-B5,B35 cross-reacting group is a large and serologically complex antigen family which includes the World Health Organization-recognized specificities HLA-B5,B51,Bw52,B35,Bw53,B18,Bw70,Bw71, and Bw72. In addition, several variants of antigens in this cross-reacting group have been described in the past but have...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90035-9
更新日期:1989-11-01 00:00:00
abstract::Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eli...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.04.018
更新日期:2009-08-01 00:00:00
abstract::We compared the immunohistochemical reaction patterns of HLA-G-specific antibodies 87G, 4H84, G233, 16G1, and BFL.1 on human placentas under three different preparative conditions and on cryosections of other human tissues. Human and murine cell lines, either naturally expressing or transfected with HLA-G, were analyz...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00207-x
更新日期:2000-11-01 00:00:00
abstract::Mannose-binding lectin (MBL) role in the carriage of oropharyngeal bacteria is not known. We investigated the association of smoking, MBL2 polymorphisms, and MBL concentrations with oropharyngeal carriage of respiratory bacteria in young men. Oropharyngeal specimens, MBL concentrations, and MBL2 gene polymorphisms wer...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.12.009
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). METHODS:A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA),...
journal_title:Human immunology
pub_type: 杂志文章,meta分析
doi:10.1016/j.humimm.2012.07.341
更新日期:2012-10-01 00:00:00
abstract::During T-cell maturation, thymocytes interact with thymic stromal major histocompatibility complex (MHC) determinants and thymic hormones, and proliferate, apparently in response to MHC gene products, in the absence of antigen. The maturing thymocytes also express a series of cell surface molecules, at one stage coexp...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(86)90304-6
更新日期:1986-12-01 00:00:00
abstract::Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Changing concentrations of transcriptional cofactors or chemicals in transiently transfected tissue culture cells modify several properties of glucocorticoid receptor-regulated gene expression including total activity (A(max)...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.029
更新日期:2009-10-01 00:00:00
abstract::The Ia-like antigens of hybrids of the B-lymphoblastoid cell line (B-LCL) WI-L2 and a subline of the T-lymphoblastoid cell line (T-LCL) HSB were examined. Antigens of the HLA-DR and MT series were analyzed by indirect immunofluorescence with chimpanzee anti-DR sera and monoclonal antibodies, and antigens of the SB ser...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(83)90011-3
更新日期:1983-10-01 00:00:00
abstract::The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90038-4
更新日期:1989-11-01 00:00:00
abstract::Antigen-selected T cell receptor (TCR) repertoires vary in complexity from very limited to extremely diverse. We have previously characterized two different CD8 T cell responses, which are restricted by the same mouse major histocompatibility complex (MHC) class I molecule, H-2 Kd. The TCR repertoire in the response a...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(97)00082-7
更新日期:1997-05-01 00:00:00
abstract::M proteins are coiled-coil dimers expressed on group A streptococcal cell surfaces. They have an important role in host antistreptococcal immunity and in poststreptococcal autoimmune sequelae. Controversy has arisen regarding whether type 5 M proteins are superantigenic for human T cells. To investigate this, we have ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/S0198-8859(97)00028-1
更新日期:1997-04-01 00:00:00