Abstract:
:Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis. Here, we investigate the clinical significance of FCN2 in African children with either mild or severe malaria (n = 130 and n = 108, respectively) from Gabon by analyzing three promoter SNPs (-986G>A, -602G>A, and -4A>G) and one single nucleotide polymorphisms (SNP) in exon 8 (+6424G>T) using quantitative TaqMan, real-time polymerase chain reaction (PCR). In addition, we measured the ficolin-2 plasma levels at two time points: on admission (t(0), acute disease) and 4 weeks after treatment (t(1), healthy phase). Comparison of ficolin-2 plasma levels shows that ficolin-2 concentration is highest during acute severe disease. In addition, we determined polymorphisms in the promoter and all coding regions of FCN2 in 40 Gabonese. Linkage disequilibrium data revealed polymorphic allelic combination patterns in the FCN2 promoter region; strong allelic combinations at -986 and -4, and -557 and -64 were found. No FCN2 promoter haplotypes were significantly distributed between mild and severe cases.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Faik I,Oyedeji SI,Idris Z,de Messias-Reason IJ,Lell B,Kremsner PG,Kun JFdoi
10.1016/j.humimm.2010.10.003subject
Has Abstractpub_date
2011-01-01 00:00:00pages
74-9issue
1eissn
0198-8859issn
1879-1166pii
S0198-8859(10)00517-3journal_volume
72pub_type
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