Abstract:
:The 5' cis-regulatory region of the CCR5 gene exhibits a strong signature of balancing selection in several human populations. Here we analyze the polymorphism of this region in Amerindians from Amazonia, who have a complex demographic history, including recent bottlenecks that are known to reduce genetic variability. Amerindians show high nucleotide diversity (pi = 0.27%) and significantly positive Tajima's D, and carry haplotypes associated with weak and strong gene expression. To evaluate whether these signatures of balancing selection could be explained by demography, we perform neutrality tests based on empiric and simulated data. The observed Tajima's D was higher than that of other world populations; higher than that found for 18 noncoding regions of South Amerindians, and higher than 99.6% of simulated genealogies, which assume nonequilibrium conditions. Moreover, comparing Amerindians and Asians, the Fst for CCR5 cis-regulatory region was unusually low, in relation to neutral markers. These findings indicate that, despite their complex demographic history, South Amerindians carry a detectable signature of selection on the CCR5 cis-regulatory region.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Ramalho RF,Santos EJ,Guerreiro JF,Meyer Ddoi
10.1016/j.humimm.2010.05.022subject
Has Abstractpub_date
2010-09-01 00:00:00pages
922-8issue
9eissn
0198-8859issn
1879-1166pii
S0198-8859(10)00133-3journal_volume
71pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90552-c
更新日期:1993-12-01 00:00:00
abstract::Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00276-2
更新日期:2001-08-01 00:00:00
abstract::The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00213-5
更新日期:2000-12-01 00:00:00
abstract::Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.05.005
更新日期:2006-09-01 00:00:00
abstract::Heart transplant rejection is routinely defined by histological evaluation of endomyocardial biopsies (EMB). As elevated levels of donor derived sHLA (dsHLA) can be detected in the serum of transplanted patients just before or during rejection, quantification of donor specific soluble counterparts of HLA Class I (sHLA...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00010-5
更新日期:1999-05-01 00:00:00
abstract::Only 10% of persons infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB), indicating the existence of host genetic factors regulating disease expression. We investigated the association of human leukocyte antigen (HLA) class II genes with the susceptibility to pulmonary TB in Koreans, with speci...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.08.242
更新日期:2005-10-01 00:00:00
abstract::Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eli...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.04.018
更新日期:2009-08-01 00:00:00
abstract::Several investigators have reported that subdivisions of HLA-B44, which are not defined by available cytotoxic antisera, can be detected by cytotoxic T lymphocytes. The present study was designed to evaluate two sera which appear to recognize a specificity on some HLA-B44 and B45 positive cells and to determine whethe...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90073-9
更新日期:1984-11-01 00:00:00
abstract::Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on human T cells. We found that soluble CD52 inhibited T cell signalling by ligating Siglec-10, but the presence of Siglec-10 on human T cells has been questioned. To address this concern, we ex...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2020.01.009
更新日期:2020-01-01 00:00:00
abstract::Five techniques, the direct and the antiglobulin enhanced cytotoxicity assays, indirect immunofluorescence, the enzyme-linked immunosorbent assay, and the radioimmunoassay, were evaluated in a workshop to determine their utility in studies of the interactions of monoclonal antibodies with HLA antigens expressed on lym...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90016-7
更新日期:1982-04-01 00:00:00
abstract::FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing self-reactivity. With the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding thei...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2009.02.007
更新日期:2009-05-01 00:00:00
abstract::By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.08.279
更新日期:2008-11-01 00:00:00
abstract::To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICA5 was significantly increased in the T1D patient grou...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.032
更新日期:2006-01-01 00:00:00
abstract::We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N = 751), southern (N = 52), eastern (N = 79), western (N = 33), and central (N = 152) Mexico City, and rural communities (N = 150), to obtai...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.07.297
更新日期:2020-09-01 00:00:00
abstract::We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00094-9
更新日期:1999-01-01 00:00:00
abstract::In this study, the polymorphisms of the HLA DMA and DMB genes in patients with rheumatoid arthritis (RA) were examined.DMA and DMB typing was performed in 120 white RA patients from eastern France and 100 healthy controls, using PCR-SSO (sequence specific oligonucleotide probes) method for DMA determination and PCR-RF...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00126-3
更新日期:2000-03-01 00:00:00
abstract::The aim of this study was to assess the possible association of the functional (GT)(n) microsatellite polymorphism in the FOXP3 gene with predisposition to several autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn's disease, and celiac disease. We...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.06.001
更新日期:2005-08-01 00:00:00
abstract::The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(91)90058-h
更新日期:1991-11-01 00:00:00
abstract::The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90069-4
更新日期:1989-05-01 00:00:00
abstract::The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8+/-3.7 years. The med...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00088-9
更新日期:1999-10-01 00:00:00
abstract::A role of CD4(+) cells in the regulation of immune responses has steadily gained renewed recognition. The understanding of these T-regulatory (T-reg) cells in the generation of antitumor cytolytic T lymphocyte (CTL) response is therefore important. It has been shown that immunization with specific peptides, DNA, or tu...
journal_title:Human immunology
pub_type: 临床试验,杂志文章
doi:10.1016/j.humimm.2004.05.012
更新日期:2004-08-01 00:00:00
abstract::Few data are available concerning immune factors involved in the occurrence of new onset diabetes after transplantation (NODAT). Our objective was to determine an immune profile associated with the subsequent development of NODAT. The secondary objective was to build a predictive model of NODAT. We studied a prospecti...
journal_title:Human immunology
pub_type: 临床试验,杂志文章
doi:10.1016/j.humimm.2019.08.006
更新日期:2019-11-01 00:00:00
abstract::Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. Differences in disease association profiles of its low expression alleles have been observed in populations from different re...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.02.001
更新日期:2009-04-01 00:00:00
abstract::Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90067-0
更新日期:1989-05-01 00:00:00
abstract::This report describes a new MHC class II allele, HLA-DR beta 1*0306, discovered in a 31-year-old Norwegian male. The allele typed serologically as DRw52 (DR3) and amplified in PCR using DR52-associated group primers. This product could not be identified using established restriction digests, however. Use of Asp 700, M...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(95)00175-1
更新日期:1996-03-01 00:00:00
abstract::Recent studies have suggested a clinical significance to the detection of anti-major histocompatibility complex class I-related chain A (MICA) antibodies in transplantation. We have developed an eplet-based version of the HLAMatchmaker algorithm to assess the epitope specificity of these antibodies. Molecular viewing ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.10.003
更新日期:2008-12-01 00:00:00
abstract:HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.05.005
更新日期:2018-08-01 00:00:00
abstract::It is generally accepted that dendritic cells can be generated from either myeloid or lymphoid derived progenitors. Ample information has been collected on the development and nature of myeloid DC type 1 (DC1). In contrast, our current understanding on the origin and function of the lymphoid derived DC type 2 (DC2) is...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(02)00745-0
更新日期:2002-12-01 00:00:00
abstract::Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th17 and associated IL-17 were involved in the pathogenesis of ITP. Runt-related transcription factor 1 (RUNX1), a member of the runt domain-containing family of transcription factors, is required ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.06.004
更新日期:2016-08-01 00:00:00
abstract::The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00090-7
更新日期:1999-11-01 00:00:00