Abstract：
:FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing self-reactivity. With the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding their mechanisms of action in order to manipulate their function. One goal is to develop drugs or biologics that can enhance or abrogate their functions. Another approach is to utilize Tregs in adoptive cell-based therapy to treat autoimmune diseases or transplant-related complications. This review will focus on their therapeutic potential and mechanisms of action, particularly their interaction with dendritic cells.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Tran DQ,Shevach EMdoi
10.1016/j.humimm.2009.02.007subject
Has Abstractpub_date
2009-05-01 00:00:00pages
294-9issue
5eissn
0198-8859issn
1879-1166pii
S0198-8859(09)00047-0journal_volume
70pub_type
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