Siglec-10 expression is up-regulated in activated human CD4+ T cells.

abstract：:Recent epidemiologic and phylogenetic analyses suggest that in the human population human immunodeficiency virus (HIV-1) is a relatively new pathogen that arose by zoonotic transmission from chimpanzees. In humans the morbidity and mortality figures due to HIV infection are extremely high. In a very small percentage o...

journal_title：Human immunology

authors： Balla-Jhagjhoorsingh SS,Verschoor EJ,de Groot N,Teeuwsen VJ,Bontrop RE,Heeney JL

更新日期：2003-07-01 00:00:00

abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...

journal_title：Human immunology

authors： Okamoto N,Ando A,Kawai J,Yoshiwara T,Tsuji K,Inoko H

更新日期：1991-11-01 00:00:00

abstract：:T-cell clonal anergy induced by peptide analogs in the presence of live APC in murine systems was reported to be associated with incomplete tyrosine phosphorylation of the CD3 zeta chain followed by a lack of subsequent ZAP-70 recruitment. Furthermore, protein tyrosine phosphatase SHP-1 was associated with ZAP-70 upon...

journal_title：Human immunology

authors： Matsushita S,Nishimura Y

更新日期：1997-03-01 00:00:00

abstract：:One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...

journal_title：Human immunology

authors： De Maria A,Moretta L

更新日期：2000-01-01 00:00:00

abstract：:HLA-B∗15:02 is known as a biomarker for carbamazepine (CBZ) induced Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) in some Asian populations. Hence United States Federal Drug Administration (USFDA) recommends HLA-B∗15:02 screening for Asian and other populations with a high prevalence of HLA-B∗15:02,...

journal_title：Human immunology

authors： Gunathilake KM,Wettasinghe KT,Dissanayake VH

更新日期：2016-05-01 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is a rare chromosomal-instability syndrome associated with defective DNA repair. Approximately 90% of NBS patients are homozygous for a truncating mutation of the NBS1 gene. As development of the immune system relies on recombination, which involves repair of DNA breaks, one might pred...

journal_title：Human immunology

authors： van Engelen BG,Hiel JA,Gabreëls FJ,van den Heuvel LP,van Gent DC,Weemaes CM

更新日期：2001-12-01 00:00:00

abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...

journal_title：Human immunology

authors： Edwards CQ,Cartwright GE,Skolnick MH,Amos DB

更新日期：1980-07-01 00:00:00

abstract：:The presence of extra HLA antigens has been demonstrated, serologically and biochemically, on the surface of lymphoblasts from a patient with acute lymphoblastic leukemia of the T-cell subtype (T-ALL). Family analysis of this patient revealed the presence of the expected antigens, plus an additional HLA antigen (A24) ...

journal_title：Human immunology

authors： Orgad S,Yang SY,Gazit E,Relias V,Zaizov R,Lyson S,Yunis EJ

更新日期：1985-03-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand...

journal_title：Human immunology

authors： Giebel S,Boratyn-Nowicka A,Karabon L,Jedynak A,Pamula-Pilat J,Tecza K,Kula D,Kowal M,Frydecka I,Grzybowska E

更新日期：2014-06-01 00:00:00

abstract：:A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...

journal_title：Human immunology

authors： Michalek J,Svetlikova P,Fedora M,Klimovic M,Klapacova L,Bartosova D,Hrstkova H,Hubacek JA

更新日期：2007-09-01 00:00:00

abstract：:The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

journal_title：Human immunology

authors： Nordwig H,Kwok WW,Johnson JP

更新日期：1991-06-01 00:00:00

abstract：:By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...

journal_title：Human immunology

authors： Jiang H,Chess L

更新日期：2008-11-01 00:00:00

abstract：:To identify disease-specific T cell changes that occur in Crohn's disease (CD) the T-cell receptor (TCR) BV repertoires of lamina propria lymphocytes (LPL) from both disease-active and disease-inactive colonic tissue of three CD patients were compared by a quantitative polymerase chain reaction (qPCR) and CDR3 length ...

journal_title：Human immunology

authors： Gulwani-Akolkar B,Akolkar PN,Minassian A,McKinley M,Fisher S,Silver J

更新日期：1996-06-01 00:00:00

abstract：:Accurate identification of HLA antibodies using the single antigen bead (SAB) assay is critical for assessment of pre/post-transplant immunological risk and successful virtual crossmatching. Unfortunately, high titer HLA antibodies can be missed or underestimated in the SAB assay as a result of interference with the d...

journal_title：Human immunology

authors： Greenshields AL,Liwski RS

更新日期：2019-07-01 00:00:00

abstract：:The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors...

journal_title：Human immunology

authors： Müller C,Herbst H,Uchanska-Ziegler B,Ziegler A,Schunter F,Steiert I,Muller C,Wernet P

更新日期：1985-12-01 00:00:00

abstract：:Virtual crossmatch (VXM) compares a transplant candidate's unacceptable antigens to the HLA typing of the donor before an organ offer is accepted and, in selected cases, supplant a prospective physical crossmatch. However, deceased donor typing can be ambiguous, leading to uncertainty in compatibility prediction. We h...

journal_title：Human immunology

authors： Kaur N,Pinelli D,Kransdorf EP,Pando MJ,Smith G,Murphey CL,Kamoun M,Bray RA,Tambur A,Gragert L

更新日期：2020-01-01 00:00:00

abstract：:A case-control study was performed to establish a potential association of two TNF-α gene promoter SNPs (-238G>A and -308G>A) with occurrence of type 1 Diabetes mellitus (T1DM) in Croatian population (174 patients and 193 healthy controls). Genotypes (obtained by polymerase chain reaction-restriction fragment length p...

journal_title：Human immunology

authors： Korolija M,Hadžija M,Medvidović EP,Pavkovic P,Kapitanović S,Renar IP,Hadžija MP

更新日期：2010-12-01 00:00:00

abstract：:The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...

journal_title：Human immunology

authors： Jugdé F,Boissier C,Birebent B,Vu N,D'halluin PN,Rioux-Leclercq N,Bretagne JF,Semana G,Heresebach D

更新日期：2004-03-01 00:00:00

abstract：:Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...

journal_title：Human immunology

authors： Hetrick SJ,Schillinger KP,Zachary AA,Jackson AM

更新日期：2011-04-01 00:00:00

abstract：:We have produced a monoclonal antibody detecting an HLA class II determinant absent from DR1,2,W6, and W10 (DQW1) homozygous B lymphoblastoid cell lines (BLCL). The antibody, SFR16-PI.2, immunoprecipitates molecules with electrophoretic mobilities of DQ (DS/DC) molecules from DR7 homozygous cell lines. SFR16-PI.2 bind...

journal_title：Human immunology

authors： Radka SF,Stewart SJ,Smith SA

更新日期：1985-11-01 00:00:00

abstract：:Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...

journal_title：Human immunology

authors： Migita K,Abiru S,Maeda Y,Nakamura M,Komori A,Ito M,Fujiwara S,Yano K,Yatsuhashi H,Eguchi K,Ishibashi H

更新日期：2007-07-01 00:00:00

abstract：:This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...

journal_title：Human immunology

authors： Hu K,Yang P,Jiang Z,Hou S,Du L,Li F

更新日期：2010-07-01 00:00:00

abstract：:T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...

journal_title：Human immunology

authors： Qvigstad E,Gaudernack G,Thorsby E

更新日期：1984-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) may be related to chronic inflammation and immune-mediated conditions, and its pathogenesis involves T-cell activation and proliferation. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell act...

journal_title：Human immunology

authors： Liu Y,Liang WB,Gao LB,Pan XM,Chen TY,Wang YY,Xue H,Zhang LS,Zhang L

更新日期：2010-11-01 00:00:00

abstract：:The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3...

journal_title：Human immunology

authors： Fainboim L,Marcos Y,Pando M,Capucchio M,Reyes GB,Galoppo C,Badía I,Remondino G,Ciocca M,Ramonet M

更新日期：1994-10-01 00:00:00

abstract：:Cord blood, donated by mothers after the birth of their children, has become an accepted source of related and unrelated hematopoietic stem cells for marrow reconstitution. We estimate that some 7-8000 unrelated-donor cord blood transplants have been performed worldwide since 1993. The development of cord blood as a s...

journal_title：Human immunology

authors： Rubinstein P

更新日期：2006-06-01 00:00:00

abstract：:Activation of Toll-like receptors (TLR) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Upon TLR activation the release of defensins, including human beta defensin 2 (HBD-2), may occur. In this study, we explored the innate responses in patients with respiratory failure, with ...

journal_title：Human immunology

authors： Pace E,Giarratano A,Ferraro M,Bruno A,Siena L,Mangione S,Johnson M,Gjomarkaj M

更新日期：2011-01-01 00:00:00

abstract：:Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...

journal_title：Human immunology

authors： Miller G,Nepom GT,Reich MB,Thomas JW

更新日期：1993-04-01 00:00:00

abstract：:The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...

journal_title：Human immunology

authors： Aslani S,Sobhani S,Gharibdoost F,Jamshidi A,Mahmoudi M

更新日期：2018-03-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptor (KIR) genes constitute a multigene family whose genomic diversity is achieved through variation in gene content and allelic polymorphism within individual KIR genes. To date, 16 KIR genes and pseudogenes have been identified, and group A and group B haplotypes are characterized...

journal_title：Human immunology

authors： Whang DH,Park H,Yoon JA,Park MH

更新日期：2005-02-01 00:00:00