Epigenetics and pathogenesis of systemic sclerosis; the ins and outs.


:The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outcomes. Three epigenetic regulatory mechanisms modulate the manifestation of a gene, namely DNA methylation, histone changes, and microRNAs. Both epigenetics and genetics have been implicated in the pathogenesis of systemic sclerosis (SSc) disease. Genetic inheritance rate of SSc is low and the concordance rate in both monozygotic (MZ) and dizygotic (DZ) twins is little, implying other possible pathways in SSc pathogenesis scenario. Here, we provide an extensive overview of the studies regarding different epigenetic events which may offer insights into the pathology of SSc. Furthermore, epigenetic-based interventions to treat SSc patients were discussed.


Hum Immunol


Human immunology


Aslani S,Sobhani S,Gharibdoost F,Jamshidi A,Mahmoudi M




Has Abstract


2018-03-01 00:00:00














  • Interaction of KIR genes and G1M immunoglobulin allotypes confer susceptibility to type 2 diabetes in Puerto Rican Americans.

    abstract::The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Zuniga J,Romero V,Azocar J,Stern JN,Clavijo O,Almeciga I,Encinales L,Avendano A,Fridkis-Hareli M,Pandey JP,Yunis EJ

    更新日期:2006-11-01 00:00:00

  • Partial N-terminal sequence analysis of human class II molecules expressing the DQw3 determinant.

    abstract::HLA-DQ molecules were isolated from DRw9-homozygous and DR4-homozygous cell lines by using a monoclonal antibody HU-18, which recognizes class II molecules carrying the conventional DQw3 determinant. The partial N-terminal sequence analysis of the DQw3 molecules revealed that they have sequences homologous to those of...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Obata F,Endo T,Yoshii M,Otani F,Igarashi M,Takenouchi T,Ikeda H,Ogasawara K,Kasahara M,Wakisaka A

    更新日期:1985-09-01 00:00:00

  • Blood lymphocytes from ankylosing spondylitis patients fail to induce disease-specific cytotoxic T lymphocytes.

    abstract::The intriguing observation made by Geczy et al. (1) showing the possibility of generating specific ankylosing spondylitis--cytotoxic T lymphocytes by presenting HLA-B27+AS+ cells as antigen-specific stimulator cells prompted us (by using Geczy's approach) to identify cytotoxic T lymphocytes specific for this apparent ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Breur-Vriesendorp BS,Post FA,de Waal LP,Blokland E,Pool J,van der Linden S,Dekker-Saeys BJ,Goulmy E,Ivanyi P

    更新日期:1989-07-01 00:00:00

  • Monoclonal antibodies to sheep MHC class II molecules recognize all HLA-D or subsets of HLA-D region products.

    abstract::Six murine monoclonal antibodies raised against sheep MHC class II molecules were analyzed for reactivity with HLA-D subregion products. All the antibodies reacted with human peripheral blood lymphocytes, monocytes, and B-lymphoblastoid cell lines homozygous for various HLA-DR specificities, suggesting that the antibo...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Puri NK,de Kretser T,Brandon MR

    更新日期:1987-11-01 00:00:00

  • Cytotoxic T-cell role in renal allograft rejection and regulation. Renal allograft infiltrating cytotoxic T-cell line with suppressor-inducer function.

    abstract::We previously investigated the characteristics of renal allograft infiltrating T-cell lines that were propagated from biopsy and nephrectomy specimens designated as IG-Bip and IG-Neph, respectively, or analogous line designated IG-T-eff, which was generated by co-culturing pretransplant recipient blood with irradiated...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Emara MA,Mozes MF

    更新日期:1995-02-01 00:00:00

  • Apoptotic DNA binds to HLA class II molecules inhibiting antigen presentation and participating in the development of anti-inflammatory functional behavior of phagocytic macrophages.

    abstract::Resident macrophages are mainly responsible for the clearance of apoptotic cells from tissue by phagocytosis. Phagocytosis of apoptotic cells is not accompanied by activation of inflammatory mechanisms, unlike what happens when necrotic phenomena occur. We analyzed the effect of phagocytosis of apoptotic bodies on mac...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Filaci G,Contini P,Fravega M,Fenoglio D,Azzarone B,Julien-Giron M,Fiocca R,Boggio M,Necchi V,De Lerma Barbaro A,Merlo A,Rizzi M,Ghio M,Setti M,Puppo F,Zanetti M,Indiveri F

    更新日期:2003-01-01 00:00:00

  • CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus.

    abstract::The cytotoxic T-lymphocyte antigen 4 (CTLA4, CD152) gene is a positional and functional candidate gene to susceptibility to systemic lupus erythematosus (SLE) because CTLA4 gene maps in the described SLE risk region 2q33 and CTLA4 molecule has an inhibitory effect on T-cell activation. Several polymorphisms have been ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Aguilar F,Torres B,Sánchez-Román J,Núñez-Roldán A,González-Escribano MF

    更新日期:2003-10-01 00:00:00

  • Meta-analysis reveals an association of STAT4 polymorphisms with systemic autoimmune disorders and anti-dsDNA antibody.

    abstract::Signal transducer and activator of transcription 4 (STAT4) has been recently identified as a susceptibility gene for multiple autoimmune diseases. Here we performed a comprehensive analysis of the association between STAT4 and several different autoimmune disorders to identify potential common inflammatory principles ...

    journal_title:Human immunology

    pub_type: 杂志文章,meta分析


    authors: Zheng J,Yin J,Huang R,Petersen F,Yu X

    更新日期:2013-08-01 00:00:00

  • Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia.

    abstract::The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Prins JR,van der Hoorn MLP,Keijser R,Ris-Stalpers C,van Beelen E,Afink GB,Claas FHJ,van der Post JAM,Scherjon SA

    更新日期:2016-01-01 00:00:00

  • Haplotype analysis of killer cell immunoglobulin-like receptor genes in 77 Korean families.

    abstract::Killer cell immunoglobulin-like receptor (KIR) genes constitute a multigene family whose genomic diversity is achieved through variation in gene content and allelic polymorphism within individual KIR genes. To date, 16 KIR genes and pseudogenes have been identified, and group A and group B haplotypes are characterized...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Whang DH,Park H,Yoon JA,Park MH

    更新日期:2005-02-01 00:00:00

  • Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma: comparison to other interferons.

    abstract::This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as fo...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Capobianchi MR,Ameglio F,Tosi R,Dolei A

    更新日期:1985-05-01 00:00:00

  • Independence of measles-specific humoral and cellular immune responses to vaccination.

    abstract::With a larger, independent cohort and more sophisticated measures, we sought to confirm our work that indicated independence of humoral and cellular immunity following measles vaccination. We recruited an age-stratified random cohort of 764 healthy subjects from all socioeconomic strata, all with medical-record docume...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Jacobson RM,Ovsyannikova IG,Vierkant RA,Pankratz VS,Poland GA

    更新日期:2012-05-01 00:00:00

  • Discordant expression of HLA class II-associated co-chaperones and HLA-DRB alleles in cultured fibroblast-like synoviocytes.

    abstract::Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Spurrell DR,Oldford SA,Frost T,Larsen B,Codner D,Edgecombe A,Drover S

    更新日期:2004-12-01 00:00:00

  • Idiotypic vaccine for treatment of human B-cell lymphoma. Construction of IgG variable regions from single malignant B cells.

    abstract::Immunoglobulin idiotypes (Id) of malignant B cells represent highly specific markers which can be used for vaccination. PCR-amplification of immunoglobulin genes enables the rapid production of large amounts of Id vaccines. However, the separate amplification and subsequent recombination of heavy and light chains can ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Terness P,Welschof M,Moldenhauer G,Jung M,Moroder L,Kirchhoff F,Kipriyanov S,Little M,Opelz G

    更新日期:1997-08-01 00:00:00

  • Role of galectin-3 in the pathogenesis of bladder transitional cell carcinoma.

    abstract::Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing evidence that galectins are implicated in essential biological processes such as cellular communication, inflammation, differentiation and apoptosis. Galectin-3 is one of the best-known galectins, which is found in ver...

    journal_title:Human immunology

    pub_type: 杂志文章,评审


    authors: Zeinali M,Adelinik A,Papian S,Khorramdelazad H,Abedinzadeh M

    更新日期:2015-10-01 00:00:00

  • Prolongation of small bowel allograft survival with a sequential therapy consisting of a synthetic MHC class II peptide and temporarily low-dose cyclosporine A.

    abstract::It has been extensively documented the role of the indirect pathway of allorecognition in allograft rejection. However, recent data demonstrate that the manipulation of this pathway could be also sufficient to promote prolongation of allograft survival. In the present study we evaluated the effect of preoperative immu...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Otto C,Gasser M,Waaga-Gasser AM,Rohde AC,Lenhard M,Jost S,Gassel HJ,Ulrichs K,Timmermann W

    更新日期:2002-10-01 00:00:00

  • Identification of the amino acid residues contributing to monoclonal antibody-defined DQw1 epitopes.

    abstract::The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Nordwig H,Kwok WW,Johnson JP

    更新日期:1991-06-01 00:00:00

  • Hepatitis C virus-related hepatocellular carcinoma and B-cell lymphoma patients show a different profile of major histocompatibility complex class II alleles.

    abstract::Comparison of human leukocyte antigen (HLA) frequencies in patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and in patients with HCV-associated non-Hodgkin's lymphoma (NHL) has not been addressed previously. To this aim, we investigated the distribution of HLA class II alleles in two sel...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: De Re V,Caggiari L,Talamini R,Crovatto M,De Vita S,Mazzaro C,Cannizzaro R,Dolcetti R,Boiocchi M

    更新日期:2004-11-01 00:00:00

  • Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child.

    abstract::Pregnancy can prime the maternal humoral immune response against paternal human leukocyte antigens (HLA) of the child. Previous studies have reported that formation of antibodies against inherited paternal HLA is associated with the presence of primed cytotoxic T lymphocytes (CTLs) specific for these antigens. Recentl...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: van Kampen CA,Versteeg-vd Voort Maarschalk MF,Langerak-Langerak J,Roelen DL,Claas FH

    更新日期:2002-06-01 00:00:00

  • Antigen, allele, and haplotype frequencies report of the ASHI minority antigens workshops: part 1, African-Americans.

    abstract::HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...

    journal_title:Human immunology

    pub_type: 多中心研究


    authors: Zachary AA,Bias WB,Johnson A,Rose SM,Leffell MS

    更新日期:2001-10-01 00:00:00

  • Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients.

    abstract::The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Ben-Ali M,Barreiro LB,Chabbou A,Haltiti R,Braham E,Neyrolles O,Dellagi K,Gicquel B,Quintana-Murci L,Barbouche MR

    更新日期:2007-11-01 00:00:00

  • Polymorphism in the upstream regulatory region of DQA1 genes and DRB1, QAP, DQA1, and DQB1 haplotypes in the German population.

    abstract::Polymorphism in the URR of the MHC class II DQA1 gene defines ten different alleles named QAP. Oligotyping for the alleles of DRB1, QAP, DQA1, and DQB1 have been performed in 210 unrelated healthy controls from Germany. Moreover, 83 HTCs from the Tenth IHWS have been tested. Four point loci haplotypes (DRB1, QAP, DQA1...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Haas JP,Kimura A,Andreas A,Hochberger M,Keller E,Brünnler G,Bettinotti MP,Nevinny-Stickel C,Hildebrandt B,Sierp G

    更新日期:1994-01-01 00:00:00

  • Soluble HLA class I antigens in patients with type I diabetes and their family members.

    abstract::Our objective was to study a possible contribution of MHC genes to S-HLA-I secretion in patients with Type I diabetes. Quantitatively, we used a highly sensitive enzyme-linked immunoassay to measure S-HLA-I in the serum of a total of 39 patients with Type I diabetes, as well as 36 kinships of 12 diabetic patients and ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Adamashvili I,McVie R,Gelder F,Gautreaux M,Jaramillo J,Roggero T,McDonald J

    更新日期:1997-07-01 00:00:00

  • Human melanoma cell secreting human leukocyte antigen-G5 inhibit natural killer cell cytotoxicity by impairing lytic granules polarization toward target cell.

    abstract::Human leukocyte antigen-G (HLA-G) is a nonclassical tolerogenic molecule that can be expressed either as membrane bound (HLA-G1) or secreted (HLA-G5) isoforms. Upregulation of HLA-G1 or HLA-G5 expression by tumor cells constitutes an efficient way to escape from antitumoral immune responses. The inhibitory role of HLA...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Lesport E,Baudhuin J,LeMaoult J,Sousa S,Doliger C,Carosella ED,Favier B

    更新日期:2009-12-01 00:00:00

  • Recognition by HLA-A2-restricted cytotoxic T lymphocytes of endogenously generated and exogenously provided synthetic peptide analogues of the influenza A virus matrix protein.

    abstract::Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed antigens. Lysis of cells sensitized with exogenously provided and endo...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Sauma SY,Gammon MC,Bednarek MA,Cunningham B,Biddison WE,Hermes JD,Porter G,Tamhankar S,Hawkins JC,Bush BL

    更新日期:1993-08-01 00:00:00

  • The presentation of self and allogeneic MHC peptides to T lymphocytes.

    abstract::The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rej...

    journal_title:Human immunology

    pub_type: 杂志文章,评审


    authors: Benichou G,Malloy KM,Tam RC,Heeger PS,Fedoseyeva EV

    更新日期:1998-09-01 00:00:00

  • Analysis of the adequate size of a cord blood bank and comparison of HLA haplotype distributions between four populations.

    abstract::The number of units and especially the number of different HLA haplotypes present in a cord blood (CB) bank is a crucial determinant of its usefulness. We generated data relevant to the development of our national CB in Finland. The HLA haplotype distribution was examined between specific populations. We developed gra...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Haimila K,Penttilä A,Arvola A,Auvinen MK,Korhonen M

    更新日期:2013-02-01 00:00:00

  • HLA class I and class II allele and haplotype distribution in the Venezuelan population.

    abstract::Population studies represent an integral part, and a necessary link in a complex chain of host-pathogen interactions, disease pathogenesis, and major histocompatibility complex polymorphism. HLA class I and class II allele and haplotype distributions among Venezuelan mestizos were determined. Genes of Mongoloid, Negro...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Makhatadze NJ,Franco MT,Layrisse Z

    更新日期:1997-06-01 00:00:00

  • Impact on mid-term kidney graft outcomes of pretransplant anti-HLA antibodies detected by solid-phase assays: Do donor-specific antibodies tell the whole story?

    abstract::The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Malheiro J,Tafulo S,Dias L,Martins S,Fonseca I,Beirão I,Castro-Henriques A,Cabrita A

    更新日期:2017-09-01 00:00:00

  • Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival.

    abstract::Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eli...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Vlad G,Ho EK,Vasilescu ER,Colovai AI,Stokes MB,Markowitz GS,D'Agati VD,Cohen DJ,Ratner LE,Suciu-Foca N

    更新日期:2009-08-01 00:00:00