Epigenetics and pathogenesis of systemic sclerosis; the ins and outs.

Abstract:

:The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outcomes. Three epigenetic regulatory mechanisms modulate the manifestation of a gene, namely DNA methylation, histone changes, and microRNAs. Both epigenetics and genetics have been implicated in the pathogenesis of systemic sclerosis (SSc) disease. Genetic inheritance rate of SSc is low and the concordance rate in both monozygotic (MZ) and dizygotic (DZ) twins is little, implying other possible pathways in SSc pathogenesis scenario. Here, we provide an extensive overview of the studies regarding different epigenetic events which may offer insights into the pathology of SSc. Furthermore, epigenetic-based interventions to treat SSc patients were discussed.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Aslani S,Sobhani S,Gharibdoost F,Jamshidi A,Mahmoudi M

doi

10.1016/j.humimm.2018.01.003

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

178-187

issue

3

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(18)30014-4

journal_volume

79

pub_type

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