Immune phenotype predicts new onset diabetes after kidney transplantation.

abstract：:More insight into the differential immunogenicity of human leukocyte antigen (HLA) mismatches will be beneficial for donor selection in clinical transplantation. In this study the immunogenicity of HLA antigens was analyzed by examining the antibody profiles in women who have been pregnant. In total 888 women, who had...

journal_title：Human immunology

authors： Dankers MK,Roelen DL,Korfage N,de Lange P,Witvliet M,Sandkuijl L,Doxiadis II,Claas FH

更新日期：2003-06-01 00:00:00

abstract：:M proteins are coiled-coil dimers expressed on group A streptococcal cell surfaces. They have an important role in host antistreptococcal immunity and in poststreptococcal autoimmune sequelae. Controversy has arisen regarding whether type 5 M proteins are superantigenic for human T cells. To investigate this, we have ...

journal_title：Human immunology

authors： Degnan B,Taylor J,Hawkes C,O'Shea U,Smith J,Robinson JH,Kehoe MA,Boylston A,Goodacre JA

更新日期：1997-04-01 00:00:00

abstract：:Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obta...

journal_title：Human immunology

authors： Montero-Martín G,Mallempati KC,Gangavarapu S,Sánchez-Gordo F,Herrero-Mata MJ,Balas A,Vicario JL,Sánchez-García F,González-Escribano MF,Muro M,Moya-Quiles MR,González-Fernández R,Ocejo-Vinyals JG,Marín L,Creary LE,Osoegawa K

更新日期：2019-07-01 00:00:00

abstract：:The presence of extra HLA antigens has been demonstrated, serologically and biochemically, on the surface of lymphoblasts from a patient with acute lymphoblastic leukemia of the T-cell subtype (T-ALL). Family analysis of this patient revealed the presence of the expected antigens, plus an additional HLA antigen (A24) ...

journal_title：Human immunology

authors： Orgad S,Yang SY,Gazit E,Relias V,Zaizov R,Lyson S,Yunis EJ

更新日期：1985-03-01 00:00:00

abstract：:HLA-B703 (BPOT) is a B7-like antigen segregating within families. To determine the complete B*0703 nucleotide sequence, HLA-ABC-cDNAs derived from the EBV cell line POT71 have been cloned. Four B*0703-positive clones were sequenced to obtain an accurate consensus sequence. With respect to the isoelectric focusing-iden...

journal_title：Human immunology

authors： Bergmans AM,Tijssen H,Lardy N,Reekers P

更新日期：1993-10-01 00:00:00

abstract：:The capacity of MHC class I to protect target cells from NK is well established, but the mechanism by which these molecules influence NK recognition and the physical properties associated with this function remain poorly defined. We have examined this issue using as a model the HLA-A11 allele. HLA-A11 expression corre...

journal_title：Human immunology

authors： Gavioli R,Zhang QJ,Masucci MG

更新日期：1996-08-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) freshly isolated from human ovarian carcinomas were phenotyped (up to 75% CD3+ HLA-DR+ cells) and cultured in the presence of recombinant interleukin 2 and tumor necrosis factor alpha. In short-term cultures, an initial outgrowth of CD3+ CD8+ T lymphocytes resulted in the enrichmen...

journal_title：Human immunology

authors： Vaccarello L,Wang YL,Whiteside TL

更新日期：1990-06-01 00:00:00

abstract：:Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...

journal_title：Human immunology

authors： Migita K,Abiru S,Maeda Y,Nakamura M,Komori A,Ito M,Fujiwara S,Yano K,Yatsuhashi H,Eguchi K,Ishibashi H

更新日期：2007-07-01 00:00:00

abstract：:As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...

journal_title：Human immunology

authors： Verbruggen LA,Versaen H,Rebmann V,Duquet W,De Cock S,Grosse-Wilde H,Demanet C

更新日期：2002-09-01 00:00:00

abstract：:CD4(+) Th2 helper cell mediated immune responses have been shown to play a crucial role in the pathogenesis of ABPA. HLA and TCR are the candidate genes, which can influence the specificity of these responses. We have previously established a strong association of HLA DR2/5 in ABPA susceptibility. The study was design...

journal_title：Human immunology

authors： Chauhan B,Hutcheson PS,Slavin RG,Bellone CJ

更新日期：2002-04-01 00:00:00

abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

journal_title：Human immunology

authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

更新日期：2003-05-01 00:00:00

abstract：:This study aimed at evaluating the functional activation and activating receptors expression on resting, short- and long-term NK and NK-like T cells from blood of ovarian neoplasia patients. Blood from patients with adnexal benign alterations (n = 10) and ovarian cancer (grade I-IV n = 14) were collected after signed ...

journal_title：Human immunology

authors： da Silva RF,Petta CA,Derchain SF,Alici E,Guimarães F

更新日期：2014-08-01 00:00:00

abstract：:CD1 glycoproteins are a class of antigen presenting molecules that bind and present non-peptidic antigens (lipids and glycolipids) for immune recognition. CD1 polymorphisms, although limited, could have a critical role in antimicrobial, anticancer, and autoimmune responses and disease susceptibility. Ethnic difference...

journal_title：Human immunology

authors： Aureli A,Aboulaghras S,Oumhani K,Del Beato T,Sebastiani P,Colanardi A,El Aouad R,Ben El Barhdadi I,Piancatelli D

更新日期：2020-07-01 00:00:00

abstract：:We followed 138 Spanish patients (37 men and 101 women) with rheumatoid arthritis (RA) to analyze whether patient sex influenced the HLA-DRB1 associations with disease susceptibility. Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specifi...

journal_title：Human immunology

authors： Gonzalez-Escribano MF,Rodriguez R,Valenzuela A,Garcia A,Núñez-Roldan A

更新日期：1999-12-01 00:00:00

abstract：:The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analys...

journal_title：Human immunology

authors： Hurley CK,Fernandez-Vina M,Hildebrand WH,Noreen HJ,Trachtenberg E,Williams TM,Baxter-Lowe LA,Begovich AB,Petersdorf E,Selvakumar A,Stastny P,Hegland J,Hartzman RJ,Carston M,Gandham S,Kollman C,Nelson G,Spellman S,Sett

更新日期：2007-01-01 00:00:00

abstract：:Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...

journal_title：Human immunology

authors： Rebmann V,Switala M,Eue I,Schwahn E,Merzenich M,Grosse-Wilde H

更新日期：2007-04-01 00:00:00

abstract：:Interleukin (IL)-1 gene polymorphisms affect several inflammatory diseases, including cancer. Therefore, we studied genetic association of biallelic (-511C>T) polymorphism of IL-1 beta and 86-bp VNTR polymorphism of IL-1RN in 159 patients with esophageal cancer (EC) and 194 age- and gender-matched healthy controls. Ge...

journal_title：Human immunology

authors： Upadhyay R,Jain M,Kumar S,Ghoshal UC,Mittal B

更新日期：2008-03-01 00:00:00

abstract：:Serological and immunochemical studies showed that monoclonal antibody Q2/70 (MoAb Q2/70), produced by the hybridoma technique, is specific for human Ia-like antigens. This antibody recognizes an antigenic determinant which is different from those defining the serologic polymorphism of Ia-like antigens, and is express...

journal_title：Human immunology

authors： Quaranta V,Indiveri F,Glassy MC,Ng A,Russo C,Molinaro GA,Pellegrino MA,Ferrone S

更新日期：1980-10-01 00:00:00

abstract：:The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3...

journal_title：Human immunology

authors： Fainboim L,Marcos Y,Pando M,Capucchio M,Reyes GB,Galoppo C,Badía I,Remondino G,Ciocca M,Ramonet M

更新日期：1994-10-01 00:00:00

abstract：:It has been reported that collagen II (CII) derived peptide CII263-272 induced T-cell activation via its amino acids responsible for T-cell receptor (TCR) recognition. The impact of substitution of the TCR contacting amino acids of CII263-272 on T-cell activation was evaluated in this study using a panel of altered CI...

journal_title：Human immunology

authors： Zhou Q,Cheng Y,Lü H,Zhou W,Li Z

更新日期：2003-09-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

journal_title：Human immunology

authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

更新日期：2010-02-01 00:00:00

abstract：:CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN...

journal_title：Human immunology

authors： Chen Q,Yuan S,Sun H,Peng L

更新日期：2019-03-01 00:00:00

abstract：:We previously investigated the characteristics of renal allograft infiltrating T-cell lines that were propagated from biopsy and nephrectomy specimens designated as IG-Bip and IG-Neph, respectively, or analogous line designated IG-T-eff, which was generated by co-culturing pretransplant recipient blood with irradiated...

journal_title：Human immunology

authors： Emara MA,Mozes MF

更新日期：1995-02-01 00:00:00

abstract：:Dendritic cells (DCs) exposed to tumor antigens followed by treatment with T(h)1-polarizing differentiation signals have paved the way for the development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have i...

journal_title：Human immunology

authors： Holmstrøm K,Pedersen AW,Claesson MH,Zocca MB,Jensen SS

更新日期：2010-01-01 00:00:00

abstract：:The existence of dendritic cell (DC) subsets is firmly established, but their trafficking properties are still largely unknown. We have indicated that myeloid dendritic cells (M-DCs) and plasmacytoid dendritic cells (P-DCs) isolated from human blood differ widely in the capacity to migrate to chemotactic stimuli. The ...

journal_title：Human immunology

authors： Penna G,Vulcano M,Sozzani S,Adorini L

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...

journal_title：Human immunology

authors： Jalalonmuhali M,Caroll R,Deayton S,Emery T,Humphreys I,Lim SJ,Lim SK,Coates T

更新日期：2020-12-01 00:00:00

abstract：:In order to investigate the distribution of epitopes recognized by T-cell clones directed against HLA class II products, bulk primed cell populations were generated using cells matched for class I determinants but disparate for class II determinants. Cells were cloned by single cell deposition (FACS IV) or limiting di...

journal_title：Human immunology

authors： Reinsmoen NL,Bach FH

更新日期：1986-08-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand...

journal_title：Human immunology

authors： Giebel S,Boratyn-Nowicka A,Karabon L,Jedynak A,Pamula-Pilat J,Tecza K,Kula D,Kowal M,Frydecka I,Grzybowska E

更新日期：2014-06-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated ...

journal_title：Human immunology

authors： Papp M,Lakatos PL,Harsfalvi J,Farkas G,Palatka K,Udvardy M,Molnar T,Farkas K,Nagy F,Veres G,Lakatos L,Kovacs A,Dinya T,Kocsis AK,Papp J,Hungarian IBD Study Group.,Altorjay I

更新日期：2010-04-01 00:00:00

abstract：:Idiopathic achalasia is an esophageal motor disorder of unknown etiology. A wealth of evidence supports the concept that achalasia is an immune-mediated disease. According to this evidence, achalasia has been significantly associated with specific alleles of the human leukocyte antigen class II, PTPN22 and IL23R. Seve...

journal_title：Human immunology

authors： Nuñez C,García-González MA,Santiago JL,Benito MS,Mearín F,de la Concha EG,de la Serna JP,de León AR,Urcelay E,Vigo AG

更新日期：2011-09-01 00:00:00