Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population.

abstract：:In vitro primary sensitization of human peripheral blood T-cells to hemocyanins was detected during a 12-14 day culture period with antigen (KLH or HCH)-pulsed macrophages. Primed T-cells proliferate in secondary culture (2-3 days) when restimulated with antigen presented by macrophages. The kinetics of primary sensit...

journal_title：Human immunology

authors： Ford D,Hamblin A,Dumonde D,Burger D

更新日期：1982-06-01 00:00:00

abstract：:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...

journal_title：Human immunology

authors： Nunez G,Stastny P

更新日期：1983-01-01 00:00:00

abstract：:In humans, the in vitro antibody response directed towards mannan, a polysaccharide extracted from the cell wall of Candida albicans, has been previously shown to be dependent on the presence of T lymphocytes and monocytes. Evidence is now given for the existence of a genetic restriction governing this response since ...

journal_title：Human immunology

authors： Durandy A,Fischer A,Charron DJ,Griscelli C

更新日期：1986-05-01 00:00:00

abstract：:Nucleotide sequences of alleles encoding four serologically defined splits of the HLA-A10 group, A26.1, A26.3, A26.4, and A10SA, were determined. It was confirmed that the alleles coding for A26.1 and A26.3 are identical with A*2602 and A*2601, respectively. On the other hand, alleles for A26.4 and A10SA are thus far ...

journal_title：Human immunology

authors： Ishikawa Y,Tokunaga K,Lin L,Imanishi T,Saitou S,Kimura A,Kashiwase K,Akaza T,Tadokoro K,Juji T

更新日期：1994-03-01 00:00:00

abstract：:The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...

journal_title：Human immunology

authors： Frumento G,Molina F,Pernis B,Ferrara GB

更新日期：1994-09-01 00:00:00

abstract：:Human T suppressor cells (Ts), capable of preventing autologous T helper cells (Th) from reacting against xenogeneic pig endothelial cells and pig APC can be generated in vitro. Ts derive from a population of CD3(+)CD8(+)CD28(-) T lymphocytes and specifically recognize the MHC class I antigens of the APC used for in v...

journal_title：Human immunology

authors： Ciubotariu R,Li J,Colovai AI,Platt JL,Cortesini R,Suciu Foca Cortesini N

更新日期：2001-05-01 00:00:00

abstract：:Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...

journal_title：Human immunology

authors： Voorter CE,Drent M,van den Berg-Loonen EM

更新日期：2005-07-01 00:00:00

abstract：:Beta-1,4-galactosyltransferase I (β-1,4-GalT-I) mediates several biological mechanisms as a key enzyme in glycobiology, but the role of β-1,4-GalT-I in immune system remains unclear. We conducted experiments to investigate whether β-1,4-GalT-I is participating in the activation of Jurkat T cell and intercellular conta...

journal_title：Human immunology

authors： Sun X,Wu Y,Wang Y,Xue Q,Cheng X,Zhang G,Zhu Y,Wang X

更新日期：2014-10-01 00:00:00

abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...

journal_title：Human immunology

authors： Grifoni A,Weiskopf D,Lindestam Arlehamn CS,Angelo M,Leary S,Sidney J,Frazier A,Phillips E,Mallal S,Mack SJ,Tippalagama R,Goonewardana S,Premawansa S,Premawansa G,Wijewickrama A,De Silva AD,Sette A

更新日期：2018-02-01 00:00:00

abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...

journal_title：Human immunology

authors： Okamoto N,Ando A,Kawai J,Yoshiwara T,Tsuji K,Inoko H

更新日期：1991-11-01 00:00:00

abstract：:This study aimed at evaluating the functional activation and activating receptors expression on resting, short- and long-term NK and NK-like T cells from blood of ovarian neoplasia patients. Blood from patients with adnexal benign alterations (n = 10) and ovarian cancer (grade I-IV n = 14) were collected after signed ...

journal_title：Human immunology

authors： da Silva RF,Petta CA,Derchain SF,Alici E,Guimarães F

更新日期：2014-08-01 00:00:00

abstract：:Antigen-selected T cell receptor (TCR) repertoires vary in complexity from very limited to extremely diverse. We have previously characterized two different CD8 T cell responses, which are restricted by the same mouse major histocompatibility complex (MHC) class I molecule, H-2 Kd. The TCR repertoire in the response a...

journal_title：Human immunology

authors： Maryanski JL,Casanova JL,Falk K,Gournier H,Jaulin C,Kourilsky P,Lemonnier FA,Lüthy R,Rammensee HG,Rötzschke O,Servis C,López JA

更新日期：1997-05-01 00:00:00

abstract：:The Fas-FasL system plays a crucial role in the maintenance of homeostasis in the immune system. To characterize the Fas/FasL system in macaque monkeys that are commonly used as experimental primates, we cloned and sequenced Fas cDNA derived from the cynomolgus monkey. The predicted amino acid sequence consists of 331...

journal_title：Human immunology

authors： Murayama Y,Terao K,Inoue-Murayama M

更新日期：2000-05-01 00:00:00

abstract：:The tumor necrosis factor (TNF) and TNF receptor (TNF-TNFR) superfamily plays crucial roles in immune regulation and host immune responses. The superfamily has been also associated with many immune-mediated diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and diabetes. In order to investigate...

journal_title：Human immunology

authors： Cho SM,Kim J,Ryu HJ,Kim JJ,Kim HH,Park JH,Kim HT,Kim KH,Cho HY,Oh B,Park C,Kimm K,Jo I,Lee JE,Shin HD,Lee JK

更新日期：2004-07-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection has been associated with enhanced expression of HLA antigens on the endothelium and with cellular infiltrates within the graft following human organ transplantation. We investigated the interactions between human cytomegalovirus-infected cultured endothelial cells and cocultured ...

journal_title：Human immunology

authors： Scholz M,Blaheta RA,Cinatl J,Encke A,Doerr HW,Markus BH

更新日期：1995-11-01 00:00:00

abstract：:The aim of this study was to examine the role of single nucleotide polymorphisms (SNPs) and haplotypes of the tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene in Hungarians with psoriasis and psoriatic arthritis. A case-control study was performed, and five TNFSF15 SNPs (rs3810936, rs6478108, rs647810...

journal_title：Human immunology

authors： Képíró L,Széll M,Kovács L,Keszthelyi P,Kemény L,Gyulai R

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...

journal_title：Human immunology

authors： Jalalonmuhali M,Caroll R,Deayton S,Emery T,Humphreys I,Lim SJ,Lim SK,Coates T

更新日期：2020-12-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine th...

journal_title：Human immunology

authors： Gu D,Chen Z,Zhao H,Du W,Xue F,Ge J,Sui T,Wu H,Liu B,Lu S,Zhang L,Yang R

更新日期：2010-06-01 00:00:00

abstract：:The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 5...

journal_title：Human immunology

authors： Bojko A,Ostasz R,Białecka M,Klimowicz A,Malinowski D,Budawski R,Bojko P,Droździk M,Kurzawski M

更新日期：2018-04-01 00:00:00

abstract：:Recent data puts WNT signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. The key effectors in the WNT signaling pathway are low-density lipoprotein receptor-related protein 5 (LRP5), transcription factor 7-like 2 (TCF7L2), and downstream-r...

journal_title：Human immunology

authors： Wang J,Yan G,Zhang J,Gao K,Zhang M,Li L,Wang Y,Wang Q,Zhai Y,You H,Ren Y,Wang B,Hu D

更新日期：2015-05-01 00:00:00

abstract：:Quechua Amerindians established Inca Empire and chose Cuzco as their capital. Their language is closely related to that of Aymara ethnic group and both of them were originated from Titikaka Lake Altiplano area. In the present study we have analyzed Bolivian Quechua HLA profile and found that it has common characters w...

journal_title：Human immunology

authors： Arnaiz-Villena A,Juarez I,Lopez-Nares A,Crespo-Yuste E,Callado A,Suarez-Trujillo F

更新日期：2020-07-01 00:00:00

abstract：:There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...

journal_title：Human immunology

authors： Bangham CR,Bushell A,Wood KJ,Morris PJ

更新日期：1988-02-01 00:00:00

abstract：:Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...

journal_title：Human immunology

authors： Tassiulas I,Park-Min KH,Hu Y,Kellerman L,Mevorach D,Ivashkiv LB

更新日期：2007-03-01 00:00:00

abstract：:The cytotoxic T-lymphocyte antigen 4 (CTLA4, CD152) gene is a positional and functional candidate gene to susceptibility to systemic lupus erythematosus (SLE) because CTLA4 gene maps in the described SLE risk region 2q33 and CTLA4 molecule has an inhibitory effect on T-cell activation. Several polymorphisms have been ...

journal_title：Human immunology

authors： Aguilar F,Torres B,Sánchez-Román J,Núñez-Roldán A,González-Escribano MF

更新日期：2003-10-01 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disorder characterized by fatigability and weakness of striated muscles. Its association with HLA molecules is well known and varies depending on age, sex and the ethnicity of the patients. A case-control study was performed in 61 Cuban patients and 81 controls using polymeras...

journal_title：Human immunology

authors： Sylvia T,Samuel M,Luis G,Zuzet M

更新日期：2013-08-01 00:00:00

abstract：:While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...

journal_title：Human immunology

authors： Schöfl G,Schmidt AH,Lange V

更新日期：2016-03-01 00:00:00

abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

journal_title：Human immunology

authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

更新日期：1997-09-15 00:00:00

abstract：:Dendritic cells (DCs) play an important role in inducing immune tolerance. Inhibitory receptors, such as ILT2/CD85j, are involved in the tolerogenic effect of DCs and previous studies have indicated the important role of these receptors on the pathogenesis of autoimmune diseases. The aim of this study was to evaluate ...

journal_title：Human immunology

authors： Monsiváis-Urenda A,Gómez-Martin D,Santana-de-Anda K,Cruz-Martínez J,Alcocer-Varela J,González-Amaro R

更新日期：2013-09-01 00:00:00

abstract：:To clarify the molecular relationship between HLA loci and ulcerative colitis (UC) in Japanese patients, we performed HLA-DP genotyping by the PCR-RFLP method and studied tumor necrosis factor beta-chain genetic polymorphism by Southern hybridization, in addition to conventional serologic typing. Significant increase ...

journal_title：Human immunology

authors： Sugimura K,Asakura H,Mizuki N,Inoue M,Hibi T,Yagita A,Tsuji K,Inoko H

更新日期：1993-02-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...

journal_title：Human immunology

authors： Bonfigli S,Fozza C,Contini S,Buzzetti R,Cucca F,Longinotti M

更新日期：2007-05-01 00:00:00