Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis.

abstract：:Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...

journal_title：Human immunology

authors： Miller G,Nepom GT,Reich MB,Thomas JW

更新日期：1993-04-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

journal_title：Human immunology

authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

更新日期：2010-02-01 00:00:00

abstract：:A role of CD4(+) cells in the regulation of immune responses has steadily gained renewed recognition. The understanding of these T-regulatory (T-reg) cells in the generation of antitumor cytolytic T lymphocyte (CTL) response is therefore important. It has been shown that immunization with specific peptides, DNA, or tu...

journal_title：Human immunology

authors： Chakraborty NG,Chattopadhyay S,Mehrotra S,Chhabra A,Mukherji B

更新日期：2004-08-01 00:00:00

abstract：:One of the major categories of disease-causing micro-organisms are viruses. New studies on many different viruses have shown that virus attachment and cell entry is often a multistep process, requiring many interactions between the virus and cell surface molecules. In this study, we have attempted to identify the cell...

journal_title：Human immunology

authors： Triantafilou M,Triantafilou K,Wilson KM

更新日期：2000-09-01 00:00:00

abstract：:Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...

journal_title：Human immunology

authors： Shah AS,Leffell MS,Lucas D,Zachary AA

更新日期：2009-02-01 00:00:00

abstract：:The capacity of MHC class I to protect target cells from NK is well established, but the mechanism by which these molecules influence NK recognition and the physical properties associated with this function remain poorly defined. We have examined this issue using as a model the HLA-A11 allele. HLA-A11 expression corre...

journal_title：Human immunology

authors： Gavioli R,Zhang QJ,Masucci MG

更新日期：1996-08-01 00:00:00

abstract：:The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...

journal_title：Human immunology

authors： Frumento G,Molina F,Pernis B,Ferrara GB

更新日期：1994-09-01 00:00:00

abstract：:T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...

journal_title：Human immunology

authors： Qvigstad E,Gaudernack G,Thorsby E

更新日期：1984-12-01 00:00:00

abstract：:The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors...

journal_title：Human immunology

authors： Müller C,Herbst H,Uchanska-Ziegler B,Ziegler A,Schunter F,Steiert I,Muller C,Wernet P

更新日期：1985-12-01 00:00:00

abstract：:The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...

journal_title：Human immunology

authors： Silveira-Lessa AL,Quinello C,Lima L,Redondo ACC,Ceccon MEJR,Carneiro-Sampaio M,Palmeira P

更新日期：2016-10-01 00:00:00

abstract：:A comprehensive system for genetic typing of the HLA class I A locus is described, based on PCR amplification and typing with nonradioactively labeled SSO probes. Exons 1-3 of the A locus are amplified and typing is performed with a set of 30 nonradioactively labeled oligonucleotide probes. This system resolves 34 of ...

journal_title：Human immunology

authors： Allen M,Liu L,Gyllensten U

更新日期：1994-05-01 00:00:00

abstract：:Neem leaf preparation (NLP) was found to activate natural killer (NK) cells (CD56(+)CD3(-)) to enhance their cytotoxic ability to tumor cells and stimulate the release of interleukin-12 (IL-12) from macrophages from healthy individuals and head-and-neck squamous cell carcinoma patients. NLP upregulated cytotoxic (CD16...

journal_title：Human immunology

authors： Bose A,Baral R

更新日期：2007-10-01 00:00:00

abstract：:Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...

journal_title：Human immunology

authors： Taylor M,Bergemann TL,Hussain A,Thompson PD,Spector L

更新日期：2011-10-01 00:00:00

abstract：:TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...

journal_title：Human immunology

authors： Raaphorst FM,Schelonka RL,Rusnak J,Infante AJ,Teale JM

更新日期：2002-01-01 00:00:00

abstract：:An interesting class of immune responses is that in which an environmental agent modifies a self-protein. Heparin induced thrombocytopenia (HIT) is associated with an antibody response in which the immunogen is a self-protein, platelet factor 4 (PF4), modified by an external agent, heparin. We tested the hypothesis th...

journal_title：Human immunology

authors： Bacsi S,Geoffrey R,Visentin G,De Palma R,Aster R,Gorski J

更新日期：2001-02-01 00:00:00

abstract：:To elucidate the residues important for the binding of peptides to HLA-Cw3, a substitutional analysis of two HLA-Cw*0304-binding peptides was performed. The optimal registry and length for a Cw3-restricted epitope from HIV-1 p24gag was determined to be a nonamer, p24gag 144-152. Substituted analogs of this nonamer pep...

journal_title：Human immunology

authors： Zarling AL,Lee DR

更新日期：1998-08-01 00:00:00

abstract：:To evaluate the role of LMP (low molecular weight protein) genes as susceptibility markers for spondyloarthritis (SpA), LMP gene polymorphisms were analyzed in 223 Mexican patients with SpA (81 undifferentiated SpA [U-SpA], 117 with ankylosing spondylitis [AS], 25 with reactive arthritis) and in 139 ethnically matched...

journal_title：Human immunology

authors： Vargas-Alarcón G,Gamboa R,Zuñiga J,Fragoso JM,Hernández-Pacheco G,Londoño J,Pacheco-Tena C,Cardiel MH,Granados J,Burgos-Vargas R

更新日期：2004-12-01 00:00:00

abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

journal_title：Human immunology

authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

更新日期：1997-09-15 00:00:00

abstract：:Six murine monoclonal antibodies raised against sheep MHC class II molecules were analyzed for reactivity with HLA-D subregion products. All the antibodies reacted with human peripheral blood lymphocytes, monocytes, and B-lymphoblastoid cell lines homozygous for various HLA-DR specificities, suggesting that the antibo...

journal_title：Human immunology

authors： Puri NK,de Kretser T,Brandon MR

更新日期：1987-11-01 00:00:00

abstract：:NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit a considerable degree of genetic polymorphism, and although the functional significance of such allelic variation remains unclear, genetic vari...

journal_title：Human immunology

authors： Antoun A,Jobson S,Cook M,O'Callaghan CA,Moss P,Briggs DC

更新日期：2010-06-01 00:00:00

abstract：:The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective case- control study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associa...

journal_title：Human immunology

authors： Thude H,Tiede P,Sterneck M,Peine S,Nashan B,Koch M

更新日期：2020-12-01 00:00:00

abstract：:Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant re...

journal_title：Human immunology

authors： Holder AL,Wolf S,Walshe C,Pandya P,Stanford RE,Smith JD,Rose ML,Lawson C

更新日期：2008-02-01 00:00:00

abstract：:The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

journal_title：Human immunology

authors： Nordwig H,Kwok WW,Johnson JP

更新日期：1991-06-01 00:00:00

abstract：:Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 w...

journal_title：Human immunology

authors： Chen Q,Yan CQ,Liu FJ,Tong J,Miao SL,Chen JP

更新日期：2008-04-01 00:00:00

abstract：:Indirect immunofluorescence staining with monoclonal antibodies has shown a differential distribution of HLA-DR, DQ, and DP antigens in normal tissues of nonlymphoid origin. The distribution of HLA-DP antigens is similar to that of HLA-DR antigens, while that of HLA-DQ antigens is more restricted. Malignant transforma...

journal_title：Human immunology

authors： Natali P,Bigotti A,Cavalieri R,Nicotra MR,Tecce R,Manfredi D,Chen YX,Nadler LM,Ferrone S

更新日期：1986-02-01 00:00:00

abstract：:HLA-G molecules seem to have a protective effect for the semi-allogeneic fetus by mother immunosuppression. Also, pregnancy pathologies have been associated to HLA-G(∗)01:05N "null allele". In addition, other general regulatory immune functions have been associated to HLA-G in infections, tumors and autoimmunity. Thus...

journal_title：Human immunology

authors： Arnaiz-Villena A,Enriquez-de-Salamanca M,Areces C,Alonso-Rubio J,Abd-El-Fatah-Khalil S,Fernandez-Honrado M,Rey D

更新日期：2013-04-01 00:00:00

abstract：:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...

journal_title：Human immunology

authors： Nunez G,Stastny P

更新日期：1983-01-01 00:00:00

abstract：:A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...

journal_title：Human immunology

authors： Kishi H,Okumura A,Tong JJ,Sugiyama E,Matsuno H,Minowada J,Kanai T,Nishimura Y,Muraguchi A

更新日期：1997-08-01 00:00:00

abstract：:It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...

journal_title：Human immunology

authors： Jason J,Inge KL

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Accurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome. METHODS:HLA genes expression analy...

journal_title：Human immunology

authors： Mine KL,Tedesco-Silva H,Mourão TB,Campos EF,Salzedas LA,Aguiar B,Felipe CR,Medina-Pestana JO,Gerbase-DeLima M

更新日期：2018-08-01 00:00:00