Identification of T cells responding to a self-protein modified by an external agent.

abstract：:Natural killer cells (NK) are pivotal cells of innate immunity. They are potent antileukemic cytotoxic effectors. A defect in their cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma and myelodysplastic syndromes. This defect is at least partially linked...

journal_title：Human immunology

authors： Sanchez C,Baier C,Colle JG,Chelbi R,Rihet P,Le Treut T,Imbert J,Sébahoun G,Venton G,Costello RT

更新日期：2015-09-01 00:00:00

abstract：:To elucidate the residues important for the binding of peptides to HLA-Cw3, a substitutional analysis of two HLA-Cw*0304-binding peptides was performed. The optimal registry and length for a Cw3-restricted epitope from HIV-1 p24gag was determined to be a nonamer, p24gag 144-152. Substituted analogs of this nonamer pep...

journal_title：Human immunology

authors： Zarling AL,Lee DR

更新日期：1998-08-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th17 and associated IL-17 were involved in the pathogenesis of ITP. Runt-related transcription factor 1 (RUNX1), a member of the runt domain-containing family of transcription factors, is required ...

journal_title：Human immunology

authors： Zhong X,Wu Y,Liu Y,Zhu F,Li X,Li D,Li Z,Zeng L,Qiao J,Chen X,Xu K

更新日期：2016-08-01 00:00:00

abstract：:The intriguing observation made by Geczy et al. (1) showing the possibility of generating specific ankylosing spondylitis--cytotoxic T lymphocytes by presenting HLA-B27+AS+ cells as antigen-specific stimulator cells prompted us (by using Geczy's approach) to identify cytotoxic T lymphocytes specific for this apparent ...

journal_title：Human immunology

authors： Breur-Vriesendorp BS,Post FA,de Waal LP,Blokland E,Pool J,van der Linden S,Dekker-Saeys BJ,Goulmy E,Ivanyi P

更新日期：1989-07-01 00:00:00

abstract：:In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common fals...

journal_title：Human immunology

authors： Poland GA,Jacobson RM

更新日期：2012-08-01 00:00:00

abstract：:NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit a considerable degree of genetic polymorphism, and although the functional significance of such allelic variation remains unclear, genetic vari...

journal_title：Human immunology

authors： Antoun A,Jobson S,Cook M,O'Callaghan CA,Moss P,Briggs DC

更新日期：2010-06-01 00:00:00

abstract：:An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with th...

journal_title：Human immunology

authors： Gomez-Casado E,Martinez-Laso J,Vargas-Alarcón G,Varela P,Diaz-Campos N,Alvarez M,Alegre R,Arnaiz-Villena A

更新日期：1997-04-15 00:00:00

abstract：:Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on human T cells. We found that soluble CD52 inhibited T cell signalling by ligating Siglec-10, but the presence of Siglec-10 on human T cells has been questioned. To address this concern, we ex...

journal_title：Human immunology

authors： Bandala-Sanchez E,Bediaga NG,Naselli G,Neale AM,Harrison LC

更新日期：2020-01-01 00:00:00

abstract：:Cumulative evidence indicates that the human interleukin-4 receptor alpha chain gene (IL-4Ralpha, CD124) is highly polymorphic in contrast to other cytokine receptor genes. Our group recently identified the IL-4Ralpha variant R551 as being strongly associated with decreased kidney allograft survival. Due to the key im...

journal_title：Human immunology

authors： Hackstein H,Hofmann H,Bohnert A,Bein G

更新日期：1999-11-01 00:00:00

abstract：:The monoclonal antibodies (MoAbs) KS3 and KS4 are secreted by hybridomas constructed with splenocytes from a BALB/c mouse sequentially immunized with the cultured lymphoid cells JKu and LG-2 which share only the HLA-B27 specificity. Serologic and immunochemical assays have shown that the two MoAbs recognize the same (...

journal_title：Human immunology

authors： Sakaguchi K,Ono R,Tsujisaki M,Richiardi P,Carbonara A,Park MS,Tonai R,Terasaki PI,Ferrone S

更新日期：1988-03-01 00:00:00

abstract：:The relevance of pre-existing HLA-antibodies (HLA-Ab) in liver transplantation (LTx) is controversial. While livers are allocated without HLA match or preoperative crossmatch testing, several studies point to an impact of donor specific antibodies (DSA) for acute rejection, bile duct complications or even graft loss. ...

journal_title：Human immunology

authors： Koch M,Marget M,Sterneck M,Fischer L,Thude H,Nashan B

更新日期：2018-07-01 00:00:00

abstract：:A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of t...

journal_title：Human immunology

authors： Harari A,Zimmerli SC,Pantaleo G

更新日期：2004-05-01 00:00:00

abstract：:A case-control study was performed to establish a potential association of two TNF-α gene promoter SNPs (-238G>A and -308G>A) with occurrence of type 1 Diabetes mellitus (T1DM) in Croatian population (174 patients and 193 healthy controls). Genotypes (obtained by polymerase chain reaction-restriction fragment length p...

journal_title：Human immunology

authors： Korolija M,Hadžija M,Medvidović EP,Pavkovic P,Kapitanović S,Renar IP,Hadžija MP

更新日期：2010-12-01 00:00:00

abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...

journal_title：Human immunology

authors： Okamoto N,Ando A,Kawai J,Yoshiwara T,Tsuji K,Inoko H

更新日期：1991-11-01 00:00:00

abstract：:This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as fo...

journal_title：Human immunology

authors： Capobianchi MR,Ameglio F,Tosi R,Dolei A

更新日期：1985-05-01 00:00:00

abstract：:Resident macrophages are mainly responsible for the clearance of apoptotic cells from tissue by phagocytosis. Phagocytosis of apoptotic cells is not accompanied by activation of inflammatory mechanisms, unlike what happens when necrotic phenomena occur. We analyzed the effect of phagocytosis of apoptotic bodies on mac...

journal_title：Human immunology

authors： Filaci G,Contini P,Fravega M,Fenoglio D,Azzarone B,Julien-Giron M,Fiocca R,Boggio M,Necchi V,De Lerma Barbaro A,Merlo A,Rizzi M,Ghio M,Setti M,Puppo F,Zanetti M,Indiveri F

更新日期：2003-01-01 00:00:00

abstract：:It is generally accepted that dendritic cells can be generated from either myeloid or lymphoid derived progenitors. Ample information has been collected on the development and nature of myeloid DC type 1 (DC1). In contrast, our current understanding on the origin and function of the lymphoid derived DC type 2 (DC2) is...

journal_title：Human immunology

authors： Blom B,Ligthart SJ,Schotte R,Spits H

更新日期：2002-12-01 00:00:00

abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...

journal_title：Human immunology

authors： Edwards CQ,Cartwright GE,Skolnick MH,Amos DB

更新日期：1980-07-01 00:00:00

abstract：:Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...

journal_title：Human immunology

authors： Gedde-Dahl T 3rd,Eriksen JA,Thorsby E,Gaudernack G

更新日期：1992-04-01 00:00:00

abstract：:The HLA-DQA1*05 with DQB1*02 alleles are a major risk factor for celiac disease (CD). To search for additional human leukocyte antigen (HLA) risk factors, we looked on the DR3-DQ2 risk haplotype, selected because it carries both DQ risk alleles in cis and is the more represented among CD patients. In a European consor...

journal_title：Human immunology

authors： Louka AS,Moodie SJ,Karell K,Bolognesi E,Ascher H,Greco L,Momigliano-Richiardi P,Partanen J,Ciclitira PJ,Sollid LM,European Genetics Cluster on Celiac Disease.

更新日期：2003-03-01 00:00:00

abstract：:The difficulty of molecular typing of the HLA class I genes and the relevance of the genes of this region to disease susceptibility and transplantation have provided an impetus to develop useful typing markers. We have characterized by polymerase chain reaction analysis a new highly informative CA repeat localized app...

journal_title：Human immunology

authors： Grimaldi MC,Clayton J,Pontarotti P,Cambon-Thomsen A,Crouau-Roy B

更新日期：1996-12-01 00:00:00

abstract：:The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective case- control study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associa...

journal_title：Human immunology

authors： Thude H,Tiede P,Sterneck M,Peine S,Nashan B,Koch M

更新日期：2020-12-01 00:00:00

abstract：:Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experi...

journal_title：Human immunology

authors： Pesando JM,Nadler LM,Lazarus H,Tomaselli KJ,Stashenko P,Ritz J,Levine H,Yunis EJ,Schlossman SF

更新日期：1981-08-01 00:00:00

abstract：:HLA-B∗15:02 is known as a biomarker for carbamazepine (CBZ) induced Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) in some Asian populations. Hence United States Federal Drug Administration (USFDA) recommends HLA-B∗15:02 screening for Asian and other populations with a high prevalence of HLA-B∗15:02,...

journal_title：Human immunology

authors： Gunathilake KM,Wettasinghe KT,Dissanayake VH

更新日期：2016-05-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients comprise at least 20% of treated patients and are at high risk for coronary artery abnormalities. If identified early in the course of the disease, such patients may benefit from additional anti-inflammatory therapy. The aim of this study was t...

journal_title：Human immunology

authors： Fury W,Tremoulet AH,Watson VE,Best BM,Shimizu C,Hamilton J,Kanegaye JT,Wei Y,Kao C,Mellis S,Lin C,Burns JC

更新日期：2010-09-01 00:00:00

abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

journal_title：Human immunology

authors： Macardle PJ,Wheatland L,Zola H

更新日期：1999-02-01 00:00:00

abstract：:Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...

journal_title：Human immunology

authors： Rebmann V,Switala M,Eue I,Schwahn E,Merzenich M,Grosse-Wilde H

更新日期：2007-04-01 00:00:00

abstract：:While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...

journal_title：Human immunology

authors： Schöfl G,Schmidt AH,Lange V

更新日期：2016-03-01 00:00:00

abstract：:A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We hav...

journal_title：Human immunology

authors： Shaut DM,Ireland J,Scornik JC,Peck AB

更新日期：1983-06-01 00:00:00

abstract：:We have investigated the polymorphism of TAP genes and the distribution of human leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out ...

journal_title：Human immunology

authors： Whang DH,Park H,Roh EY,Park MH

更新日期：2005-09-01 00:00:00