Abstract:
:The intriguing observation made by Geczy et al. (1) showing the possibility of generating specific ankylosing spondylitis--cytotoxic T lymphocytes by presenting HLA-B27+AS+ cells as antigen-specific stimulator cells prompted us (by using Geczy's approach) to identify cytotoxic T lymphocytes specific for this apparent B27+AS+ target structure. Peripheral blood mononuclear cells (PBMC) of 21 healthy B27+ individuals were stimulated in primary and in short-term cultures with PBMC of an HLA-identical sibling suffering from definite AS (n = 12). In addition, PBMC in vitro modified by "Geczy bacterial products" from two healthy B27+ individuals were used to stimulate B27+ AS- lymphocytes (either autologous or from a healthy HLA-identical sibling). Effector cells raised in primary AS- versus AS+ and AS- versus "modified B27" mixed lymphocyte culture combinations showed no proliferative nor cytotoxic activity at all. The scarcely observed cytotoxic reactivity of restimulated mixed lymphocyte culture was not restricted to AS+B27+ cells. These results demonstrate that PBMC from ankylosing spondylitis patients fail to induce disease-specific cytotoxic T lymphocytes and suggest that an ankylosing spondylitis--related "modified B27" structure does not exist, at least in the patient material tested.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Breur-Vriesendorp BS,Post FA,de Waal LP,Blokland E,Pool J,van der Linden S,Dekker-Saeys BJ,Goulmy E,Ivanyi Pdoi
10.1016/0198-8859(89)90078-5subject
Has Abstractpub_date
1989-07-01 00:00:00pages
149-55issue
3eissn
0198-8859issn
1879-1166pii
0198-8859(89)90078-5journal_volume
25pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Rat soluble MHC class I synthesis was studied at both RNA and protein levels to determine whether multiple forms of soluble MHC class I molecules are produced by different mechanisms. RT-PCR and sequencing of MHC class I transcripts identified an alternatively spliced nonclassical MHC class I gene product, lacking bot...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00039-1
更新日期:1998-07-01 00:00:00
abstract::During HLA-DQ oligotyping, the presence of a novel HLA-DQB1 allele was suggested by a pattern of probe hybridization that was inconsistent with the presence of any possible combination of two known alleles. The nucleotide sequence of the second exon of the HLA-DQB1 gene was determined, revealing a novel HLA-DQB1 seque...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90075-x
更新日期:1992-03-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) may be related to chronic inflammation and immune-mediated conditions, and its pathogenesis involves T-cell activation and proliferation. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell act...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.08.007
更新日期:2010-11-01 00:00:00
abstract::Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90128-n
更新日期:1993-04-01 00:00:00
abstract::Monoclonal antibodies have played an important role in studying the biochemistry of the HLA-Class I molecules. Some murine anti-HLA mAbs can identify configurations of HLA epitopes that have never been reported in human allosera. One of these configurations is identified by an IgM mAb designated as: BHA-1441. This ant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00254-3
更新日期:2001-07-01 00:00:00
abstract::Myasthenia gravis (MG) is a neuromuscular disorder characterized by fatigability and weakness of striated muscles. Its association with HLA molecules is well known and varies depending on age, sex and the ethnicity of the patients. A case-control study was performed in 61 Cuban patients and 81 controls using polymeras...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.04.027
更新日期:2013-08-01 00:00:00
abstract:AIMS:We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. PATIENTS AND METHODS:46 IPF patients underwent genotyping, 43 of them had HRCT and 14 patients had a sur...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.07.011
更新日期:2013-10-01 00:00:00
abstract::In our earlier studies, single nucleotide polymorphisms (SNPs) associated with anti-inflammatory cytokines were found to influence risk for breast cancer in western Indian women. Analysis of Interleukin 6 (IL-6) -174G>C polymorphism in this cohort (patients = 182; controls = 236) suggested a protective role for IL-6 -...
journal_title:Human immunology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.humimm.2014.06.018
更新日期:2014-08-01 00:00:00
abstract::Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.03.010
更新日期:2007-07-01 00:00:00
abstract::An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00008-6
更新日期:1997-04-15 00:00:00
abstract:BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.10.014
更新日期:2017-02-01 00:00:00
abstract::Mannose-binding lectin (MBL) role in the carriage of oropharyngeal bacteria is not known. We investigated the association of smoking, MBL2 polymorphisms, and MBL concentrations with oropharyngeal carriage of respiratory bacteria in young men. Oropharyngeal specimens, MBL concentrations, and MBL2 gene polymorphisms wer...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.12.009
更新日期:2010-03-01 00:00:00
abstract::Oxidized low-density lipoproteins and Toll-like receptors (TLR) 2 and 4 are involved in the development of atherosclerosis. The TLR are important in the pro-inflammatory response. The aim of this research was to analyze the activation of CD14, TLR4, and TLR2 in response to minimally modified low-density lipoprotein (m...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.05.005
更新日期:2010-08-01 00:00:00
abstract::Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00028-7
更新日期:1998-06-01 00:00:00
abstract::Heart transplant rejection is routinely defined by histological evaluation of endomyocardial biopsies (EMB). As elevated levels of donor derived sHLA (dsHLA) can be detected in the serum of transplanted patients just before or during rejection, quantification of donor specific soluble counterparts of HLA Class I (sHLA...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00010-5
更新日期:1999-05-01 00:00:00
abstract::Genomic aberrations in the CREBBP (CREB-binding protein - CREBBP or CBP) gene such as point mutations, small insertions or exonic copy number changes are usually associated with Rubinstein-Taybi syndrome (RTs). In this study, the disruption of the CREBBP gene on chromosome 16p13.3, as revealed by CGH-array and FISH, s...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.04.024
更新日期:2013-08-01 00:00:00
abstract::The cellular basis of graft rejection and the development of strategies for specific suppression of T cell responses against allogeneic and xenogeneic transplants represents an area of active investigation. Recently, a population of MHC-class I restricted CD8+CD28- T suppressor cells (Ts) which are able to inhibit spe...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00134-7
更新日期:1999-04-01 00:00:00
abstract::This review discusses the current understanding of biomarkers of immune quiescence based on reviews of published literature in kidney transplant operational tolerance and mechanistic studies based on a better characterization of the stable, well-functioning renal allograft. ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.016
更新日期:2018-05-01 00:00:00
abstract::The cytotoxic T-lymphocyte antigen 4 (CTLA4, CD152) gene is a positional and functional candidate gene to susceptibility to systemic lupus erythematosus (SLE) because CTLA4 gene maps in the described SLE risk region 2q33 and CTLA4 molecule has an inhibitory effect on T-cell activation. Several polymorphisms have been ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00171-x
更新日期:2003-10-01 00:00:00
abstract::The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune mo...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2019.09.006
更新日期:2020-04-01 00:00:00
abstract::Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed antigens. Lysis of cells sensitized with exogenously provided and endo...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90508-x
更新日期:1993-08-01 00:00:00
abstract::To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gram(-)) or gram-positive (gram(+)) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing betwee...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.01.009
更新日期:2009-04-01 00:00:00
abstract::Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.12.002
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:When donor specific HLA antibodies (DSA) are identified, the predictive value of whether a certain strength of reactivity (mean fluorescence intensity, MFI) leads to a positive crossmatch is uncertain. To determine this, we compared the DSA MFI results we generated locally for nationally distributed proficiency...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.05.009
更新日期:2018-08-01 00:00:00
abstract::The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.230
更新日期:2016-10-01 00:00:00
abstract::This study examined the performance of a tuberculosis (TB)-specific enzyme-linked immunospot assay in 48 patients awaiting liver transplantation. They were tested with T-SPOT.TB, tuberculin skin test (TST), and lymphocyte transformation test (LTT) using tuberculin as a stimulus. A questionnaire was used to gain inform...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.10.005
更新日期:2009-01-01 00:00:00
abstract::Dendritic cells (DCs) exposed to tumor antigens followed by treatment with T(h)1-polarizing differentiation signals have paved the way for the development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have i...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.10.001
更新日期:2010-01-01 00:00:00
abstract::The genetic polymorphism of the fourth component of human complement, C4, was studied in 945 unrelated Caucasian individuals. A third allele of the C4F (Rodgers) locus, termed C4F1 was demonstrated. This allele is characterized using immunofixation electrophoresis, by the presence of an additional fast-moving anodal b...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(80)90006-3
更新日期:1980-07-01 00:00:00
abstract::Several risk factors including immune deficiencies, infections, and autoimmune diseases have been established for non-Hodgkin's lymphoma (NHL). For diffuse large B cell lymphoma (DLBCL), the most common type of lymphoma, no risk factors have been described, which may be due to the intrinsic heterogeneity of this disor...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.03.019
更新日期:2006-04-01 00:00:00
abstract::Killer cell immunoglobulin-like receptor (KIR) genes constitute a multigene family whose genomic diversity is achieved through variation in gene content and allelic polymorphism within individual KIR genes. To date, 16 KIR genes and pseudogenes have been identified, and group A and group B haplotypes are characterized...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.10.013
更新日期:2005-02-01 00:00:00