Abstract：
:During HLA-DQ oligotyping, the presence of a novel HLA-DQB1 allele was suggested by a pattern of probe hybridization that was inconsistent with the presence of any possible combination of two known alleles. The nucleotide sequence of the second exon of the HLA-DQB1 gene was determined, revealing a novel HLA-DQB1 sequence differing from the DQB1*0301 allele by a single nucleotide substitution at codon 57. All published HLA-DQ oligotyping systems could assign inaccurate oligotypes when this allele is present. An additional amplification primer was utilized to achieve discrimination of all possible combinations of known HLA-DQB1 alleles.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Fenske TS,Baxter-Lowe LAdoi
10.1016/0198-8859(92)90075-xsubject
Has Abstractpub_date
1992-03-01 00:00:00pages
224-7issue
3eissn
0198-8859issn
1879-1166pii
0198-8859(92)90075-Xjournal_volume
33pub_type
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