TCRBV12 genes are polymorphic but the protein products encoded by each gene are conserved.

Abstract:

:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are conservative. Although allelic variants exist for each of the three BV12 genes, only one protein product is encoded by each gene.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Deulofeut H,Wilderson JL,Barron KS,Robinson MA

doi

10.1016/0198-8859(94)00152-g

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

227-30

issue

3

eissn

0198-8859

issn

1879-1166

pii

0198-8859(94)00152-G

journal_volume

43

pub_type

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