DNA sequence analysis of the HLA-DRw12 allele.

abstract：:The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors...

journal_title：Human immunology

authors： Müller C,Herbst H,Uchanska-Ziegler B,Ziegler A,Schunter F,Steiert I,Muller C,Wernet P

更新日期：1985-12-01 00:00:00

abstract：:T lymphoblasts sensitized in vitro to tetanus toxoid (TT) in 6 day cultures, acquire the capacity of stimulating the blastogenic response of "resting" autologous T lymphocytes in primary AMLC reactions. The response of lymphocytes primed against autologous-TT-sensitized-lymphoblasts (ATTSL) seems to be specific for id...

journal_title：Human immunology

authors： Suciu-Foca N,Rohowsky C,Kung P,King DW

更新日期：1984-01-01 00:00:00

abstract：:HLA-G was described as a molecule inhibiting NK and T cells functions through its receptor, ILT2. However, most functional studies of HLA-G were so far performed on heterogeneous immune populations and regardless of ILT2 expression. This may lead to an underestimation of the effect of HLA-G. Thus, considering the immu...

journal_title：Human immunology

authors： Jacquier A,Dumont C,Carosella ED,Rouas-Freiss N,LeMaoult J

更新日期：2020-04-01 00:00:00

abstract：:The first program of bone marrow transplantation in Latin America was started 5 years ago at the Federal University Hospital, Curitiba, Paraná. The results of 62 patients who underwent bone marrow transplantation are presented and discussed. ...

journal_title：Human immunology

authors： Ferreira E,Dulley FL,Morsoletto F,Neto JZ,Pasquini R

更新日期：1985-11-01 00:00:00

abstract：:This report describes a new MHC class II allele, HLA-DR beta 1*0306, discovered in a 31-year-old Norwegian male. The allele typed serologically as DRw52 (DR3) and amplified in PCR using DR52-associated group primers. This product could not be identified using established restriction digests, however. Use of Asp 700, M...

journal_title：Human immunology

authors： Fenske B,Lemieux J,Hoar D,Fitzpatrick J,Keown P

更新日期：1996-03-01 00:00:00

abstract：:TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...

journal_title：Human immunology

authors： Dave VP,Larché M,Rencher SD,Koop BF,Hurwitz JL

更新日期：1993-07-01 00:00:00

abstract：:Development of tolerance protocols requires assays or biomarkers that distinguish tolerant recipients from non-tolerant ones to be established. In addition, a thorough understanding of the plausible mechanisms associated with clinical transplant tolerance is necessary to take the field forward. Unlike the majority of ...

journal_title：Human immunology

authors： Mathew JM,Ansari MJ,Gallon L,Leventhal JR

更新日期：2018-05-01 00:00:00

abstract：:Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...

journal_title：Human immunology

authors： Tanahashi M,Yokoyama T,Kobayashi Y,Yamakawa Y,Maeda M,Fujii Y

更新日期：2001-08-01 00:00:00

abstract：:Previous studies showed that different HLA-A and -B antigens are differentially expressed in cells. Their relative quantities are genetically predetermined and inherited according to Mendelian laws. To investigate mechanisms responsible for this differential expression, a correlation study between the relative quantit...

journal_title：Human immunology

authors： Liu K,Kao KJ

更新日期：2000-08-01 00:00:00

abstract：:Accurate identification of HLA antibodies using the single antigen bead (SAB) assay is critical for assessment of pre/post-transplant immunological risk and successful virtual crossmatching. Unfortunately, high titer HLA antibodies can be missed or underestimated in the SAB assay as a result of interference with the d...

journal_title：Human immunology

authors： Greenshields AL,Liwski RS

更新日期：2019-07-01 00:00:00

abstract：:The polymorphic nature of the KIR3DL1/S1 gene complex has been investigated through the development of a polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) allele typing system. The KIR3DL1/S1 system was applied to a healthy group of Northern Irish individuals to establish allele frequencies...

journal_title：Human immunology

authors： Halfpenny IA,Middleton D,Barnett YA,Williams F

更新日期：2004-06-01 00:00:00

abstract：:The strategy of studying the putative role of RA susceptibility genetic factors in the development of juvenile idiopathic arthritis (JIA), an autoimmune disease characterized by persistent chronic arthritis, has been proven highly successful so far. Moreover, accumulated evidence indicates that an ethnic heterogeneity...

journal_title：Human immunology

authors： Dimopoulou DG,Zervou MI,Trachana M,Myrthianou E,Pratsidou-Gertsi P,Kardassis D,Garyfallos A,Goulielmos GN

更新日期：2013-09-01 00:00:00

abstract：:The existence of dendritic cell (DC) subsets is firmly established, but their trafficking properties are still largely unknown. We have indicated that myeloid dendritic cells (M-DCs) and plasmacytoid dendritic cells (P-DCs) isolated from human blood differ widely in the capacity to migrate to chemotactic stimuli. The ...

journal_title：Human immunology

authors： Penna G,Vulcano M,Sozzani S,Adorini L

更新日期：2002-12-01 00:00:00

abstract：:The aim of this study was to investigate the possible association between the inducible nitric oxide synthase (NOS2) gene promoter polymorphism, CCTTTn microsatellite, with celiac disease susceptibility. We carried out a familial study in which 53 Spanish families were genotyped by a polymerase chain reaction (PCR)-ba...

journal_title：Human immunology

authors： Rueda B,López-Nevot MA,Pascual M,Ortega E,Maldonado J,López ML,Koeleman BP,Martín J

更新日期：2002-11-01 00:00:00

abstract：:DOCK10 is a member of the dedicator of cytokinesis (DOCK) family of Rho GTPase activators preferentially expressed in lymphocytes. In this paper, we analyzed DOCK10 mRNA diversity produced because of alternative splicing. Alternative first coding exon usage led to 2 main protein-coding transcripts, DOCK10.1 and DOCK10...

journal_title：Human immunology

authors： Alcaraz-García MJ,Ruiz-Lafuente N,Sebastián-Ruiz S,Majado MJ,González-García C,Bernardo MV,Alvarez-López MR,Parrado A

更新日期：2011-07-01 00:00:00

abstract：:Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...

journal_title：Human immunology

authors： Voorter CE,Drent M,van den Berg-Loonen EM

更新日期：2005-07-01 00:00:00

abstract：:The C-type lectins DC-SIGN and L-SIGN are important pathogen-recognition receptors of the human innate immune system. Both lectins have been shown to interact with a vast range of infectious agents, including Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. In addition, DC-SIGN and L-SIGN pos...

journal_title：Human immunology

authors： Barreiro LB,Neyrolles O,Babb CL,van Helden PD,Gicquel B,Hoal EG,Quintana-Murci L

更新日期：2007-02-01 00:00:00

abstract：:Recent data puts WNT signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. The key effectors in the WNT signaling pathway are low-density lipoprotein receptor-related protein 5 (LRP5), transcription factor 7-like 2 (TCF7L2), and downstream-r...

journal_title：Human immunology

authors： Wang J,Yan G,Zhang J,Gao K,Zhang M,Li L,Wang Y,Wang Q,Zhai Y,You H,Ren Y,Wang B,Hu D

更新日期：2015-05-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB ...

journal_title：Human immunology

authors： Spurrell DR,Oldford SA,Frost T,Larsen B,Codner D,Edgecombe A,Drover S

更新日期：2004-12-01 00:00:00

abstract：:Pronase treatment is used in the flow cytometry crossmatch (FCXM) to prevent nonspecific antibody binding on B cells. However, we have observed unexpected positive results with pronase-treated T cells in human immunodeficiency virus (HIV)-infected patients. In this study, 25 HIV-infected patients without HLA antibodie...

journal_title：Human immunology

authors： Szewczyk K,Barrios K,Magas D,Sieg K,Labuda B,Jendrisak MD,Jaramillo A

更新日期：2016-06-01 00:00:00

abstract：:There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...

journal_title：Human immunology

authors： Bangham CR,Bushell A,Wood KJ,Morris PJ

更新日期：1988-02-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...

journal_title：Human immunology

authors： Bonfigli S,Fozza C,Contini S,Buzzetti R,Cucca F,Longinotti M

更新日期：2007-05-01 00:00:00

abstract：:Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...

journal_title：Human immunology

authors： Migita K,Abiru S,Maeda Y,Nakamura M,Komori A,Ito M,Fujiwara S,Yano K,Yatsuhashi H,Eguchi K,Ishibashi H

更新日期：2007-07-01 00:00:00

abstract：:Five techniques, the direct and the antiglobulin enhanced cytotoxicity assays, indirect immunofluorescence, the enzyme-linked immunosorbent assay, and the radioimmunoassay, were evaluated in a workshop to determine their utility in studies of the interactions of monoclonal antibodies with HLA antigens expressed on lym...

journal_title：Human immunology

authors： Krakauer H,Hartzman RJ,Johnson AH

更新日期：1982-04-01 00:00:00

abstract：:MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...

journal_title：Human immunology

authors： Di Rosa F,D'Oro U,Ruggiero G,Racioppi L,Acquaviva A,Ferrone S,Fontana S,Zappacosta S

更新日期：1993-12-01 00:00:00

abstract：:We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...

journal_title：Human immunology

authors： Gragert L,Madbouly A,Freeman J,Maiers M

更新日期：2013-10-01 00:00:00

abstract：:We have investigated the distribution of genotypes of a restriction fragment length polymorphism of the T-cell receptor beta-subunit gene in Caucasoid controls and patients with insulin-dependent diabetes mellitus, celiac disease, dermatitis herpetiformis, and idiopathic membranous nephropathy and also in South Indian...

journal_title：Human immunology

authors： Niven MJ,Caffrey C,Moore RH,Sachs JA,Mohan V,Festenstein H,Hoover ML,Hitman GA

更新日期：1990-04-01 00:00:00

abstract：:Antibody-mediated rejection (ABMR) is associated with poor transplant outcome. Pathogenic alloantibodies are usually directed against human leukocyte antigens (HLAs). Histological findings suggestive of ABMR usually demonstrate an anti-HLA donor-specific antibody (DSA)-mediated injury, while a small subset of patients...

journal_title：Human immunology

authors： Delville M,Charreau B,Rabant M,Legendre C,Anglicheau D

更新日期：2016-11-01 00:00:00

abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent ha...

journal_title：Human immunology

authors： Solís-Martínez R,Barquera R,Ponnandai-Shanmugavel KS,Vega-Martínez MDR,Vázquez-Castillo TV,Arrieta-Bolaños E,Clayton S,Hernández-Zaragoza DI,Bravo-Acevedo A,Immel A,Salgado-Galicia N,Zúñiga J,Yunis EJ,Bekker-Méndez C,Granados

更新日期：2020-09-01 00:00:00

abstract：:It has been reported that collagen II (CII) derived peptide CII263-272 induced T-cell activation via its amino acids responsible for T-cell receptor (TCR) recognition. The impact of substitution of the TCR contacting amino acids of CII263-272 on T-cell activation was evaluated in this study using a panel of altered CI...

journal_title：Human immunology

authors： Zhou Q,Cheng Y,Lü H,Zhou W,Li Z

更新日期：2003-09-01 00:00:00