Abstract:
:The HLA-DQA1*05 with DQB1*02 alleles are a major risk factor for celiac disease (CD). To search for additional human leukocyte antigen (HLA) risk factors, we looked on the DR3-DQ2 risk haplotype, selected because it carries both DQ risk alleles in cis and is the more represented among CD patients. In a European consortium, we identified 109 families with a parent homozygous for DQA1*05-DQB1*02. We typed ten microsatellites in the extended HLA complex, and applied the homozygous-parent transmission disequilibrium test (HPTDT) and extended-TDT to transmissions from homozygous parents. These methods eliminate confounding due to linkage disequilibrium between candidate disease loci and the known risk factor DQA1*05-DQB1*02, and are favorable when sufficient families are available. We did not find evidence of association with any single marker or allele, although weak evidence for additional risk was observed, represented by preferential transmission of six adjacent markers. We tested the largest ever reported HPTDT population in CD, providing unprecedented power. We did not find significant evidence of additional risk-modifying factors on the DR3 haplotype, independent of DQA1*05-DQB1*02, although a weak tendency was observed for the B8-DR3 haplotype. This effect should be tested in large populations with significant representations of both B8-DR3 and non-B8 DR3 haplotypes.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Louka AS,Moodie SJ,Karell K,Bolognesi E,Ascher H,Greco L,Momigliano-Richiardi P,Partanen J,Ciclitira PJ,Sollid LM,European Genetics Cluster on Celiac Disease.doi
10.1016/s0198-8859(02)00822-4subject
Has Abstractpub_date
2003-03-01 00:00:00pages
350-8issue
3eissn
0198-8859issn
1879-1166pii
S0198885902008224journal_volume
64pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90334-j
更新日期:1992-04-01 00:00:00
abstract::The role of HLA antigens in lymphocyte differentiation is strongly suggested by the existence of a recently identified immunodeficiency associated with, and probably resulting from, the lack of expression of HLA-A, B, and C antigens as well as beta2 microglobulin on various cells of hematopoietic origin. This "bare ly...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90061-6
更新日期:1981-03-01 00:00:00
abstract::Rearrangements of the T-cell Rearranging Gene (TRG) or T-cell-receptor gamma-chain genes were analyzed in 24 in vivo-sensitized alloreactive T-cell clones. This analysis represents the first complete assignment of TRG gene rearrangements to given variable and joining gene segments in nonleukemic T cells and provides s...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90050-5
更新日期:1989-02-01 00:00:00
abstract::MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90552-c
更新日期:1993-12-01 00:00:00
abstract::In vitro primary sensitization of human peripheral blood T-cells to hemocyanins was detected during a 12-14 day culture period with antigen (KLH or HCH)-pulsed macrophages. Primed T-cells proliferate in secondary culture (2-3 days) when restimulated with antigen presented by macrophages. The kinetics of primary sensit...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90035-0
更新日期:1982-06-01 00:00:00
abstract::We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and h...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.06.007
更新日期:2020-09-01 00:00:00
abstract::Our objective was to study a possible contribution of MHC genes to S-HLA-I secretion in patients with Type I diabetes. Quantitatively, we used a highly sensitive enzyme-linked immunoassay to measure S-HLA-I in the serum of a total of 39 patients with Type I diabetes, as well as 36 kinships of 12 diabetic patients and ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00096-7
更新日期:1997-07-01 00:00:00
abstract::Human leukocyte antigen-G (HLA-G) is a nonclassical tolerogenic molecule that can be expressed either as membrane bound (HLA-G1) or secreted (HLA-G5) isoforms. Upregulation of HLA-G1 or HLA-G5 expression by tumor cells constitutes an efficient way to escape from antitumoral immune responses. The inhibitory role of HLA...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.019
更新日期:2009-12-01 00:00:00
abstract::A reliable method for high-resolution HLA-DQB1 typing using a combination of PCR- restriction fragment length polymorphism (RFLP) and PCR-single strand conformation polymorphism (SSCP) analysis is described. The second exon of the DQB1 gene was subjected to PCR using generic primers and digested with two restriction e...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00069-5
更新日期:1999-09-01 00:00:00
abstract::T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90060-0
更新日期:1984-12-01 00:00:00
abstract::Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.01.005
更新日期:2011-04-01 00:00:00
abstract::The intriguing observation made by Geczy et al. (1) showing the possibility of generating specific ankylosing spondylitis--cytotoxic T lymphocytes by presenting HLA-B27+AS+ cells as antigen-specific stimulator cells prompted us (by using Geczy's approach) to identify cytotoxic T lymphocytes specific for this apparent ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90078-5
更新日期:1989-07-01 00:00:00
abstract::The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.05.001
更新日期:2017-01-01 00:00:00
abstract::Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.03.018
更新日期:2006-01-01 00:00:00
abstract::In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90005-0
更新日期:1989-12-01 00:00:00
abstract::We compared the T cell receptor (TCR) V beta gene family repertoire in peripheral blood mononuclear cells (PBMC) and lymph node (LN) cells from 7 human immunodeficiency virus (HIV)-infected patients and 3 seronegative healthy controls. Virtually all the V beta family specificities were represented in patient PBMC and ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00205-x
更新日期:1997-10-01 00:00:00
abstract::The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90046-r
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Accurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome. METHODS:HLA genes expression analy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.05.002
更新日期:2018-08-01 00:00:00
abstract::The aim of this study was to determine the prognostic significance of soluble human leukocyte antigen (HLA) class I (sHLA-I) and HLA-G molecules in lung cancer patients. A total of 23 small-cell lung cancer (SCLC) and 114 non-small-cell lung cancer (NSCLC) patients, including 55 adenocarcinoma, 46 squamous cell carcin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.015
更新日期:2010-05-01 00:00:00
abstract::The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)00152-g
更新日期:1995-07-01 00:00:00
abstract::HLA-B703 (BPOT) is a B7-like antigen segregating within families. To determine the complete B*0703 nucleotide sequence, HLA-ABC-cDNAs derived from the EBV cell line POT71 have been cloned. Four B*0703-positive clones were sequenced to obtain an accurate consensus sequence. With respect to the isoelectric focusing-iden...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90533-7
更新日期:1993-10-01 00:00:00
abstract::Perforin (PRF1) gene mutations have been associated with Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2). Substitution p.A91V (c.272C>T) in exon 2 was first described as a neutral polymorphism. Nonetheless, recent clinical evidence and functional assays, suggest a potential pathogenic role for p.A91V, especi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.10.011
更新日期:2013-01-01 00:00:00
abstract::The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We ...
journal_title:Human immunology
pub_type: 杂志文章,meta分析
doi:10.1016/j.humimm.2014.09.005
更新日期:2014-12-01 00:00:00
abstract::The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 5...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.02.003
更新日期:2018-04-01 00:00:00
abstract::Accurate identification of HLA antibodies using the single antigen bead (SAB) assay is critical for assessment of pre/post-transplant immunological risk and successful virtual crossmatching. Unfortunately, high titer HLA antibodies can be missed or underestimated in the SAB assay as a result of interference with the d...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.04.019
更新日期:2019-07-01 00:00:00
abstract::Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.011
更新日期:2016-06-01 00:00:00
abstract::Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed antigens. Lysis of cells sensitized with exogenously provided and endo...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90508-x
更新日期:1993-08-01 00:00:00
abstract::The objective of this study was to investigate whether there is an association between IL1RN polymorphism and disease susceptibility for three age-related inflammatory conditions: polymyalgia rheumatica (PMR), giant cell arteritis (GCA), and elderly-onset rheumatoid arthritis (EORA). A tandem-repeat polymorphism withi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.10.011
更新日期:2009-01-01 00:00:00
abstract::This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.018
更新日期:2008-11-01 00:00:00
abstract::A typing system for HLA-D/DR-associated PLT-defined determinants, which have been called "DP" antigens, is reported. Some of the results concerning a data interpretation system, the reproducibility of PLT results, and the correlations between the results of HLA-D, -DR, and DP typing are presented. Also, a "new" human ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90035-5
更新日期:1981-07-01 00:00:00