Abstract:
:This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as follows: class II molecules are markedly increased by IFN gamma; IFN beta has a lower enhancing effect, and IFN alpha has only a slight, if any, effect. Kinetically, the action of IFN gamma is prompter and longer lasting than that of IFN beta. DQ expression is much more enhanced by IFN gamma than either DR or BR; IFN beta has the same effect on all three subsets. Parallel changes of the cellular expression and of the shedding of these molecules are observed. A melanoma and a lymphoblastoid cell line and peripheral blood mononuclear cells show qualitatively similar modifications.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Capobianchi MR,Ameglio F,Tosi R,Dolei Adoi
10.1016/0198-8859(85)90022-9subject
Has Abstractpub_date
1985-05-01 00:00:00pages
1-11issue
1eissn
0198-8859issn
1879-1166pii
0198-8859(85)90022-9journal_volume
13pub_type
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