Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma: comparison to other interferons.

Abstract:

:This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as follows: class II molecules are markedly increased by IFN gamma; IFN beta has a lower enhancing effect, and IFN alpha has only a slight, if any, effect. Kinetically, the action of IFN gamma is prompter and longer lasting than that of IFN beta. DQ expression is much more enhanced by IFN gamma than either DR or BR; IFN beta has the same effect on all three subsets. Parallel changes of the cellular expression and of the shedding of these molecules are observed. A melanoma and a lymphoblastoid cell line and peripheral blood mononuclear cells show qualitatively similar modifications.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Capobianchi MR,Ameglio F,Tosi R,Dolei A

doi

10.1016/0198-8859(85)90022-9

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

1-11

issue

1

eissn

0198-8859

issn

1879-1166

pii

0198-8859(85)90022-9

journal_volume

13

pub_type

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