Abstract:
:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alleles have now been defined prompted us to ask the question of where polymorphism really occurs in a class I molecule. We have used a database of 275 HLA-A, HLA-B and HLA-C alleles to illustrate how extensive the polymorphism is. The data is presented here for comparison of alleles and allele families and to facilitate studies of class I structure and function.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DVdoi
10.1016/s0198-8859(97)00175-4subject
Has Abstractpub_date
1997-09-15 00:00:00pages
1-18issue
1eissn
0198-8859issn
1879-1166pii
S0198-8859(97)00175-4journal_volume
57pub_type
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