Abstract：
:In humans, the in vitro antibody response directed towards mannan, a polysaccharide extracted from the cell wall of Candida albicans, has been previously shown to be dependent on the presence of T lymphocytes and monocytes. Evidence is now given for the existence of a genetic restriction governing this response since antibody production is achieved provided that monocytes and T lymphocytes on one side and monocytes and B lymphocytes on the other side are of the same origin. In order to delineate the restriction element governing these interactions, blocking experiments have been designed using well-defined monoclonal antibody, anti-HLA class II molecules. The results clearly indicate that the restriction element belongs to the HLA-DQ molecular series, as shown in T-cell proliferation and antibody production assays in the presence of either T cells or T-cell supernatants. Incubation of isolated cell populations (T, B lymphocytes and monocytes) with the monoclonal antibody have indicated that DQ determinants are involved in the mannan presentation by monocytes to T and B cells. The HLA-DQ mediated restriction of the in vitro immune response to mannan has been observed in all the subjects tested, suggesting that mannan epitopes are preferentially, or even only, recognized in association with an unique group of HLA-class II molecules, namely HLA-DQ.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Durandy A,Fischer A,Charron DJ,Griscelli Cdoi
10.1016/0198-8859(86)90040-6subject
Has Abstractpub_date
1986-05-01 00:00:00pages
114-25issue
1eissn
0198-8859issn
1879-1166pii
0198-8859(86)90040-6journal_volume
16pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:Our objective was to study a possible contribution of MHC genes to S-HLA-I secretion in patients with Type I diabetes. Quantitatively, we used a highly sensitive enzyme-linked immunoassay to measure S-HLA-I in the serum of a total of 39 patients with Type I diabetes, as well as 36 kinships of 12 diabetic patients and ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(97)00096-7
更新日期：1997-07-01 00:00:00
abstract：:HLA-B703 (BPOT) is a B7-like antigen segregating within families. To determine the complete B*0703 nucleotide sequence, HLA-ABC-cDNAs derived from the EBV cell line POT71 have been cloned. Four B*0703-positive clones were sequenced to obtain an accurate consensus sequence. With respect to the isoelectric focusing-iden...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90533-7
更新日期：1993-10-01 00:00:00
abstract：:There is a growing body of information about the soluble forms of HLA in serum but there are only a few reports discussing sHLA in other body fluids. We quantitated sHLA-I and sHLA-II concentrations in sweat, saliva and tear samples from five normal individuals with known HLA-phenotypes. We also studied sweat samples ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00122-0
更新日期：1999-03-01 00:00:00
abstract：:Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00028-7
更新日期：1998-06-01 00:00:00
abstract：:Virus-specific T cells have been shown to cross-react with allogeneic HLA (allo-HLA) at a clonal level. However, the impact of a single virus on the allorepertoire has never been investigated at the polyclonal level. We made an inventory of the incidence and specificity of allo-HLA-cross-reactive-virus-specific CD8+ T...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.10.014
更新日期：2019-02-01 00:00:00
abstract：:In attempts to examine the relationships between serologic and structural polymorphisms of HLA-DQ molecules we have analyzed several monoclonal antibodies generated against polymorphic determinants on HLA-DQ molecules. One antibody, SFR20-DQw3, has a serologic reactivity like that of the previously characterized anti-...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(87)90076-0
更新日期：1987-04-01 00:00:00
abstract：:A two stage PCR-SSOP typing procedure, that permitted HLA-B allele assignment, was applied to DNA samples obtained from six diverse populations -Brazilian, Mexican (Series and Mestizos), Cuban (Caucasoid and Mulatto), South African Zulu, Omani, and Singapore Chinese. HLA-B allele frequencies and HLA-A/B two locus hapl...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00247-6
更新日期：2001-06-01 00:00:00
abstract：:The eotaxin gene family (eotaxin, eotaxin-2, and eotaxin-3) has been implicated in the recruitment of eosinophils, basophiles and Th2 lymphocytes that is a central aspect of allergic diseases. We previously suggested that Eo2+179T>C and Eo2+275C>T of the eotaxin-2, and Eo3+2497T>G of the eotaxin-3 were significantly a...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.01.002
更新日期：2005-03-01 00:00:00
abstract：:Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma. To determine whether HLA class II alleles are associated with atopic asthma in a population from southeast Spain (Murcia region), 213 atopic asthmatic patients and 150 controls were selected for HLA typ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(03)00109-5
更新日期：2003-08-01 00:00:00
abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.08.267
更新日期：2013-12-01 00:00:00
abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haploty...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.07.280
更新日期：2020-09-01 00:00:00
abstract：:The immunomodulatory properties of soluble human leukocyte antigen G (sHLA-G) explain its potential interest in malignancies. HLA-G frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. In this article, we will demonstrate that the plasmatic level of soluble HLA-G was significant...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2003.08.345
更新日期：2003-11-01 00:00:00
abstract：:By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2008.08.279
更新日期：2008-11-01 00:00:00
abstract：:Human leukocyte antigen (HLA) antibodies are epitope specific and not antigen specific. This work presents a case of intra-allele (IA) sensitization. A 40-year-old-man underwent transplantion with identical "broad" DR. He was apparently not sensitized to HLA antigens by complement-dependent cytotoxicity (CDC), with on...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.05.018
更新日期：2010-09-01 00:00:00
abstract：:It is generally accepted that dendritic cells can be generated from either myeloid or lymphoid derived progenitors. Ample information has been collected on the development and nature of myeloid DC type 1 (DC1). In contrast, our current understanding on the origin and function of the lymphoid derived DC type 2 (DC2) is...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(02)00745-0
更新日期：2002-12-01 00:00:00
abstract：:Routine HLA typing by serology has been supported by DNA or protein analysis of the respective molecules in cases when serologic typing was inconclusive or difficult to perform. DNA analysis by RFLP, SSO, or PCR amplification with SSP is a reliable tool for the identification of alleles. Because DNA sequences may now ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90503-s
更新日期：1993-08-01 00:00:00
abstract：:Human B cells nonspecifically activated by Epstein Barr virus (EBV) can present tetanus toxoid (TT) antigen to TT specific helper T cell lines and T cell clones. Presentation of TT antigen by EBV-B cells did not require the presence of TT specific B cells and did not involve B cell surface immunoglobulins. Immunosorbe...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(83)90039-3
更新日期：1983-11-01 00:00:00
abstract：:Dendritic cells (DCs) play an important role in inducing immune tolerance. Inhibitory receptors, such as ILT2/CD85j, are involved in the tolerogenic effect of DCs and previous studies have indicated the important role of these receptors on the pathogenesis of autoimmune diseases. The aim of this study was to evaluate ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.05.006
更新日期：2013-09-01 00:00:00
abstract：:Tumor-infiltrating lymphocytes (TIL) freshly isolated from human ovarian carcinomas were phenotyped (up to 75% CD3+ HLA-DR+ cells) and cultured in the presence of recombinant interleukin 2 and tumor necrosis factor alpha. In short-term cultures, an initial outgrowth of CD3+ CD8+ T lymphocytes resulted in the enrichmen...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90022-h
更新日期：1990-06-01 00:00:00
abstract：:Only 10% of persons infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB), indicating the existence of host genetic factors regulating disease expression. We investigated the association of human leukocyte antigen (HLA) class II genes with the susceptibility to pulmonary TB in Koreans, with speci...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.08.242
更新日期：2005-10-01 00:00:00
abstract：:The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.08.297
更新日期：2006-11-01 00:00:00
abstract：:Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. Differences in disease association profiles of its low expression alleles have been observed in populations from different re...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.02.001
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2020.07.005
更新日期：2020-12-01 00:00:00
abstract：:FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing self-reactivity. With the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding thei...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2009.02.007
更新日期：2009-05-01 00:00:00
abstract：:Many studies have shown that Human leukocyte antigen (HLA) class I alleles are associated with the development of various cancers. However, its role in hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class I allelic polymorphism is related to the development of hepatitis B virus(HBV)-associ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.02.007
更新日期：2013-06-01 00:00:00
abstract：:Idiopathic achalasia is an esophageal motor disorder of unknown etiology. A wealth of evidence supports the concept that achalasia is an immune-mediated disease. According to this evidence, achalasia has been significantly associated with specific alleles of the human leukocyte antigen class II, PTPN22 and IL23R. Seve...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.05.017
更新日期：2011-09-01 00:00:00
abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent ha...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.07.286
更新日期：2020-09-01 00:00:00
abstract：:Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2008.12.005
更新日期：2009-02-01 00:00:00
abstract：:This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as fo...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(85)90022-9
更新日期：1985-05-01 00:00:00
abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00094-9
更新日期：1999-01-01 00:00:00
