Prevalence of AT1R antibody (AT1R-Ab) among Malaysian multi-ethnic population.

Abstract:

BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of AT1R-Ab among the Malaysian population. METHODOLOGY:All sera for AT1R-Ab were collected at the University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia. The sera were centrifuged and kept refrigerated at -80 °C before being transported to the South Australian Transplantation and Immunogenetics Laboratory (SATIS). Enzyme-linked immunosorbent assay kit (One Lambda) was used for the detection of AT1R-Ab, and it was performed according to the manufacturer's instructions. The level of >17.1 U/mL was considered to be AT1R-Ab positive; 10.0-17.1 U/mL at risk, and <10.0 U/mL negative. RESULTS:A total of 115 samples were collected from 99 patients pre and post-kidney transplant recipients. From the pre-transplant sera (n = 68) 17.7% were positive, 35.3% were at risk and 47.0% were negative. The positive AT1R-Ab cohort were relatively younger, with a mean age of 34.7 ± 8.3 years old and statistically significant, with a p-value of 0.028. Among the sera that were tested positive, 19.0% were from the Chinese ethnicity, 6.7% from Malay and 16.7% from Indian. There was no difference in the rejection episodes, persistent or de novo HLA-DSA, and graft function between the group (AT1R-Ab negative vs AT1R-Ab at risk and positive) and the results were consistent in a model adjusted for all potential confounders. CONCLUSION:The prevalence of positive (>17.1 U/mL) pre-transplant AT1R-Ab was 17.7% and 35.3% were at risk (10.0-17.1 U/mL) in our pre-transplant cohort.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Jalalonmuhali M,Caroll R,Deayton S,Emery T,Humphreys I,Lim SJ,Lim SK,Coates T

doi

10.1016/j.humimm.2020.07.005

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

679-684

issue

12

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(20)30358-X

journal_volume

81

pub_type

杂志文章
  • Conversion of a human immunodeficiency virus cytotoxic T lymphocyte epitope into a high affinity HLA-Cw3 ligand.

    abstract::To elucidate the residues important for the binding of peptides to HLA-Cw3, a substitutional analysis of two HLA-Cw*0304-binding peptides was performed. The optimal registry and length for a Cw3-restricted epitope from HIV-1 p24gag was determined to be a nonamer, p24gag 144-152. Substituted analogs of this nonamer pep...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(98)00053-6

    authors: Zarling AL,Lee DR

    更新日期:1998-08-01 00:00:00

  • Soluble HLA-DR levels in serum are associated with therapy and genetic factors in rheumatoid arthritis.

    abstract::As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(02)00431-7

    authors: Verbruggen LA,Versaen H,Rebmann V,Duquet W,De Cock S,Grosse-Wilde H,Demanet C

    更新日期:2002-09-01 00:00:00

  • Analysis of the cord blood T lymphocyte response to superantigen.

    abstract::We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(98)00107-4

    authors: Macardle PJ,Wheatland L,Zola H

    更新日期:1999-02-01 00:00:00

  • Effect of delayed graft function in hypersensitized kidney transplant recipients.

    abstract::There is increased evidence about the deleterious effect of delayed graft function (DGF) in both short- and long-term kidney graft outcome. Among the mechanisms involved in the production of DGF, immune factors play a role, especially in the level of hypersensitization. From the 1389 patients transplanted at our hospi...

    journal_title:Human immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humimm.2005.01.026

    authors: López-Hoyos M,Fernández-Fresnedo G,Rodrigo E,Ruiz JC,Arias M

    更新日期:2005-04-01 00:00:00

  • Expression of extra class I major histocompatibility antigens on T-cell acute lymphoblastic leukemia (ALL) lymphoblasts.

    abstract::The presence of extra HLA antigens has been demonstrated, serologically and biochemically, on the surface of lymphoblasts from a patient with acute lymphoblastic leukemia of the T-cell subtype (T-ALL). Family analysis of this patient revealed the presence of the expected antigens, plus an additional HLA antigen (A24) ...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(85)90331-3

    authors: Orgad S,Yang SY,Gazit E,Relias V,Zaizov R,Lyson S,Yunis EJ

    更新日期:1985-03-01 00:00:00

  • Frequencies of gene variant CCR5-Δ32 in 87 countries based on next-generation sequencing of 1.3 million individuals sampled from 3 national DKMS donor centers.

    abstract::Homozygous carriers of CCR5-Δ32, a gene variant of CC-type chemokine receptor 5 (CCR5), are highly resistant to infections with human immunodeficiency virus type 1 (HIV-1) and therefore preferred stem cell donors for HIV-infected patients. We analyzed CCR5 typing data of 1,333,035 potential hematopoietic stem cell don...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2017.10.001

    authors: Solloch UV,Lang K,Lange V,Böhme I,Schmidt AH,Sauter J

    更新日期:2017-11-01 00:00:00

  • Antigen-specific T cell clones restricted by DR, DRw53 (MT), or DP (SB) Class II HLA molecules. Inhibition studies with monoclonal HLA-specific antibodies.

    abstract::T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(84)90060-0

    authors: Qvigstad E,Gaudernack G,Thorsby E

    更新日期:1984-12-01 00:00:00

  • T-cell receptor V beta selectivity in T-cell clones alloreactive to HLA-Dw14.

    abstract::The HLA-DR4 subtypes Dw14 and Dw4 are T-cell-defined allospecificities encoded by the DRB1*0404 and DRB1*0401 genes, respectively. Although these allelic subtypes differ in only two amino acids, allorecognition between Dw14 and Dw4-positive individuals is brisk. This provides an opportunity to analyze T-cell receptor ...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(92)90052-o

    authors: Yamanaka K,Kwok WW,Mickelson EM,Masewicz S,Nepom GT

    更新日期:1992-01-01 00:00:00

  • Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome.

    abstract::Felty's syndrome (FS) is a rare complication of rheumatoid arthritis (RA) previously shown to be strongly associated with HLA-DR4 and less significantly with HLA-DQw7. To map more precisely the HLA locus responsible for susceptibility to FS, we have examined HLA-DR4 and DQ beta-chain polymorphisms in FS patients and c...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(91)90117-r

    authors: Lanchbury JS,Jaeger EE,Sansom DM,Hall MA,Wordsworth P,Stedeford J,Bell JI,Panayi GS

    更新日期:1991-09-01 00:00:00

  • DR-restricted T-cell reactivities associated with the Dw19 specificity can be directed against the products of either locus DRB3 (DRw52c) or locus DRB1.

    abstract::HLA-Dw 19 antigen presenting cells express two different DR beta chains encoded respectively by DRB1 and DRB3 genes. In the present study we determined which of these two DR beta chains is recognized by DR-restricted T-cell clones. First we selected influenza-specific, DR-restricted T-cell clones of which restriction ...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(90)90029-o

    authors: Zeliszewski D,Tiercy JM,Dorval I,Kaplan C,Mach B,Sterkers G

    更新日期:1990-08-01 00:00:00

  • Interaction of penicillin with HLA-A and -B antigens.

    abstract::When lymphocytes of healthy donors were incubated with penicillin and washed before HLA typing, the cytotoxic reactivity of some typing sera with their corresponding antigen was blocked. When the penicillin was added to the cytotoxicity assay at different times, competition between penicillin and alloantiserum for bin...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(82)90033-7

    authors: Claas FH,Runia-van Nieuwkoop R,van den Berge W,van Rood JJ

    更新日期:1982-08-01 00:00:00

  • Multidrug resistance activity in human lymphocytes.

    abstract::The multidrug resistance gene (mdr1) is a member of the recently described ATP binding cassette (ABC) superfamily of transporters. Family members include: (1) the cystic fibrosis transmembrane conductance regulator gene; (2) the hlyB gene of bacteria, and (3) the histocompatibility antigen modifier (HAM) gene. The lev...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(91)90110-u

    authors: Coon JS,Wang YZ,Bines SD,Markham PN,Chong AS,Gebel HM

    更新日期:1991-10-01 00:00:00

  • Human allograft-derived T-cell lines: donor class I- and class II-directed cytotoxicity and repertoire stability in sequential biopsies.

    abstract::In order to characterize directly the T-cell repertoire utilized in human renal allograft rejection, we analyzed 20 long-term T-cell lines established from lymphocytic infiltrates present in renal tissue obtained by needle biopsy from transplant patients with rejection indications. All cell lines are strongly cytotoxi...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(88)90028-6

    authors: Miceli MC,Barry TS,Finn OJ

    更新日期:1988-07-01 00:00:00

  • Natural killer cells in patients with polycythemia vera.

    abstract::Natural killer cells (NK) are pivotal cells of innate immunity. They are potent antileukemic cytotoxic effectors. A defect in their cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma and myelodysplastic syndromes. This defect is at least partially linked...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2015.09.010

    authors: Sanchez C,Baier C,Colle JG,Chelbi R,Rihet P,Le Treut T,Imbert J,Sébahoun G,Venton G,Costello RT

    更新日期:2015-09-01 00:00:00

  • Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells.

    abstract::During T-cell maturation, thymocytes interact with thymic stromal major histocompatibility complex (MHC) determinants and thymic hormones, and proliferate, apparently in response to MHC gene products, in the absence of antigen. The maturing thymocytes also express a series of cell surface molecules, at one stage coexp...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(86)90304-6

    authors: Richardson B

    更新日期:1986-12-01 00:00:00

  • TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

    abstract:INTRODUCTION:Tyrosine kinase 2 gene (TYK2) is part of the janus kinase (JAK) that binds to the type I interferon-α receptor (IFNAR) on the cell surface of IFN-producing cells, and have crucial importance in the etiology of autoimmune and inflammatory diseases. Many polymorphisms of the TYK2 gene have been identified, a...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2012.09.007

    authors: Peluso C,Christofolini DM,Goldman CS,Mafra FA,Cavalcanti V,Barbosa CP,Bianco B

    更新日期:2013-01-01 00:00:00

  • T-cell receptor bias in patients with allergic bronchopulmonary aspergillosis.

    abstract::CD4(+) Th2 helper cell mediated immune responses have been shown to play a crucial role in the pathogenesis of ABPA. HLA and TCR are the candidate genes, which can influence the specificity of these responses. We have previously established a strong association of HLA DR2/5 in ABPA susceptibility. The study was design...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(02)00361-0

    authors: Chauhan B,Hutcheson PS,Slavin RG,Bellone CJ

    更新日期:2002-04-01 00:00:00

  • Characterization of an expressible nonclassical class I HLA gene.

    abstract::Screening of a human cosmid library representing genomic DNA from an individual homozygous for the HLA-DR2 B7 A2 haplotype yielded 109 class I HLA-specific clones. One cosmid clone, Ice 6.23, had a full-length nonclassical class I gene within a 5.4-kb HindIII fragment. The Ice 6.23-5.4H gene was cloned into the unique...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(91)90106-j

    authors: Pook MA,Woodcock V,Tassabehji M,Campbell RD,Summers CW,Taylor M,Strachan T

    更新日期:1991-10-01 00:00:00

  • Gm markers in celiac disease.

    abstract::The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(83)90065-4

    authors: Carbonara AO,DeMarchi M,van Loghem E,Ansaldi N

    更新日期:1983-02-01 00:00:00

  • Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28- T suppressor cells.

    abstract::Alloantigen specific CD8+CD28- T suppressor (TS) cells differ from naturally occurring CD4+CD25+ T-regulatory (natural TR) cells not only by their phenotype but also by their mechanism of action. Natural TR have been extensively studied, leading to the identification of characteristic "molecular markers" such as Forkh...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2004.09.004

    authors: Scotto L,Naiyer AJ,Galluzzo S,Rossi P,Manavalan JS,Kim-Schulze S,Fang J,Favera RD,Cortesini R,Suciu-Foca N

    更新日期:2004-11-01 00:00:00

  • Impact on mid-term kidney graft outcomes of pretransplant anti-HLA antibodies detected by solid-phase assays: Do donor-specific antibodies tell the whole story?

    abstract::The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant ...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2017.07.011

    authors: Malheiro J,Tafulo S,Dias L,Martins S,Fonseca I,Beirão I,Castro-Henriques A,Cabrita A

    更新日期:2017-09-01 00:00:00

  • Identification of the amino acid residues contributing to monoclonal antibody-defined DQw1 epitopes.

    abstract::The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(91)90009-x

    authors: Nordwig H,Kwok WW,Johnson JP

    更新日期:1991-06-01 00:00:00

  • Restriction fragment length polymorphism in HLA class II genes of Latin-American Caucasian celiac disease patients.

    abstract::In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(89)90005-0

    authors: Herrera M,Chertkoff L,Palavecino E,Mota A,Guala MC,Fainboim L,Satz ML

    更新日期:1989-12-01 00:00:00

  • Influence on antibody recognition of amino acid substitutions in the cleft of HLA-DQ2 molecules. Suggestive evidence of peptide-dependent epitopes.

    abstract::The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wil...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(95)00047-8

    authors: Viken HD,Paulsen G,Drover S,Marshall WH,Sollid LM,Gaudernack G,Thorsby E

    更新日期:1995-10-01 00:00:00

  • Cell-mediated cytotoxicity and the reorientation of effector cell granules towards the target cell are inhibited by the protonophore carbonylcyanide m-chlorophenylhydrazone.

    abstract::Cell-mediated cytotoxicity involves a localized secretory process in which lytic agents stored in specialized granules of the effector cells are released upon contact with the appropriate target cell membrane and cause membrane damage. The protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP) inhibits cytotoxici...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(88)90039-0

    authors: McKinnon KP,Dunlevy JR,Dawson JR,Argon Y

    更新日期:1988-06-01 00:00:00

  • Mannose-binding lectin gene polymorphisms are not associated with susceptibility to severe early childhood caries.

    abstract::Our purpose was to investigate a possible relationship between severe early childhood caries (S-ECC) and polymorphism of the mannose binding lectin gene and investigate the role of allele variant as a possible factor in the susceptibility to S-ECC. Sixty-two Chinese children with S-ECC and 68 caries-free control child...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2012.08.012

    authors: Yang Y,Wang W,Qin M

    更新日期:2013-01-01 00:00:00

  • Association of rs12979860 and rs8099917 polymorphisms near IL28B with SVR in hepatic allograft recipients with HCV recurrence undergoing PEG-IFN/RBV therapy: a meta-analysis.

    abstract::The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We ...

    journal_title:Human immunology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.humimm.2014.09.005

    authors: Zhang L,Lu Q,Yang Z,Wang X,Cai L,Liu X,Liao R,Yang X,Chen Y,Yang Z

    更新日期:2014-12-01 00:00:00

  • Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells.

    abstract::The 2',5'-oligoadenylate synthetase 1 (OAS1) is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection. A single nucleotide polymorphism (SNP), rs10774671, presumably responsible for alternate splicing of this gene, has frequently been associated with...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2012.11.011

    authors: Noguchi S,Hamano E,Matsushita I,Hijikata M,Ito H,Nagase T,Keicho N

    更新日期:2013-03-01 00:00:00

  • Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.

    abstract:OBJECTIVE:We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). METHODS:We performed a meta-analysis on the association between the four gene polymorphisms and RA. RESULTS:Nineteen studies ...

    journal_title:Human immunology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.humimm.2015.01.023

    authors: Lee YH,Bae SC,Song GG

    更新日期:2015-03-01 00:00:00

  • TLR2 and TLR4 polymorphisms in familial Mediterranean fever.

    abstract::It has been suggested that MEVF mutations offer advantage against infections, including tuberculosis. Bearing in mind the central role of TLR-2 and TLR-4 in the recognition of pathogens, we conducted this study to examine whether the TLR2-R753Q, TLR4-D299G, TLR4-T399I common polymorphisms are associated with susceptib...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2009.05.004

    authors: Speletas M,Kalala F,Mitroulis I,Papadopoulos V,Merentiti V,Germenis AE,Ritis K

    更新日期:2009-09-01 00:00:00