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HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma.

Abstract：

:Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma. To determine whether HLA class II alleles are associated with atopic asthma in a population from southeast Spain (Murcia region), 213 atopic asthmatic patients and 150 controls were selected for HLA typing. Significant association of the DRB1*01 and DQB1*0501 alleles was found in Artemisia vulgaris allergic patients (p(c) = 0.00052 and p(c) = 0.00023, respectively). No significant correlation was found in other atopic patients allergic to pollens (Phleum pratense, Olea europaea, and Salsola kali), house dust mites (Dermatophagoides pteronyssinus, D. farinae), molds (Alternaria alternata, Cladosporium herbarum), or animal danders (dog, cat). The results reveal that the DRB1*01-DQB1*0501 genotype is strongly associated with a positive response to Artemisia vulgaris in the population studied.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Torío A,Sánchez-Guerrero I,Muro M,Villar LM,Minguela A,Marín L,Moya-Quiles MR,Montes-Ares O,Pagán J,Alvarez-López MR

doi

10.1016/s0198-8859(03)00109-5

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

811-5

issue

8

eissn

0198-8859

issn

1879-1166

pii

S0198885903001095

journal_volume

64

pub_type

杂志文章

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