Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco.

Abstract:

:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Tabasco are Native American (67.79 ± 1.59% by ML; 56.25% of Native American haplotypes) and European (27.21 ± 3.97% by ML; 29.91% of European haplotypes), and a less prominent African genetic component (5.01 ± 4.42% by ML; 8.93% of African haplotypes).

journal_name

Hum Immunol

journal_title

Human immunology

authors

Solís-Martínez R,Barquera R,Ponnandai-Shanmugavel KS,Vega-Martínez MDR,Vázquez-Castillo TV,Arrieta-Bolaños E,Clayton S,Hernández-Zaragoza DI,Bravo-Acevedo A,Immel A,Salgado-Galicia N,Zúñiga J,Yunis EJ,Bekker-Méndez C,Granados

doi

10.1016/j.humimm.2019.07.286

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

560-562

issue

9

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(19)30963-2

journal_volume

81

pub_type

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