Abstract：
:Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant rejection, and diabetes. However, the functional significance of these polymorphisms has not been determined. ICAM-1 cell surface expression and ICAM-1-mediated leukocyte adhesion were investigated using Cos7 transfected with ICAM-1 polymorphic variants or human umbilical vein endothelial cells (HUVEC) of different ICAM-1 genotypes. There was significantly higher expression of surface ICAM-1 on Cos7 transfected with a plasmid encoding the GE (G241/E469) ICAM-1 variant or untreated HUVEC of GEGE (G241/E469 homozygous genotype). ICAM-1-mediated adhesion of peripheral blood mononuclear cells (PBMC) to GE-Cos7 cells or TNF-treated GEGE HUVEC was significantly increased. However, there was no significant difference in adhesion of PBMC to recombinant ICAM-1 of each polymorphic variant plated onto plastic wells. We conclude that the GE genotype of ICAM-1 is associated with greater cell surface expression of ICAM-1, which in turn leads to greater adhesion of leukocytes. This may explain the previously described associations of ICAM-1 polymorphisms with chronic inflammatory disease.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Holder AL,Wolf S,Walshe C,Pandya P,Stanford RE,Smith JD,Rose ML,Lawson Cdoi
10.1016/j.humimm.2007.12.004subject
Has Abstractpub_date
2008-02-01 00:00:00pages
71-8issue
2eissn
0198-8859issn
1879-1166pii
S0198-8859(07)00497-1journal_volume
69pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis. Here, we investigate the clinical significance of FCN2 in African children with either mild or severe malaria (n = 130 and n = 108, respectively) from Gabon by analyzing three promote...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.10.003
更新日期：2011-01-01 00:00:00
abstract：:This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FcγRIIa, CD209, VDR, TNF-α, IL-4, IL-6 and IFN-γ genes with symptom ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2015.09.026
更新日期：2015-10-01 00:00:00
abstract：:MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90552-c
更新日期：1993-12-01 00:00:00
abstract：:In this study, the polymorphisms of the HLA DMA and DMB genes in patients with rheumatoid arthritis (RA) were examined.DMA and DMB typing was performed in 120 white RA patients from eastern France and 100 healthy controls, using PCR-SSO (sequence specific oligonucleotide probes) method for DMA determination and PCR-RF...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00126-3
更新日期：2000-03-01 00:00:00
abstract：:The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.11.005
更新日期：2017-02-01 00:00:00
abstract：:In an attempt to develop a suitable model for increasing the yield of human anti-HLA mAbs, we have used mice with SCID for i.p. injection of two human-mouse heterohybridomas. HMP1 hybridoma secretes a DQB1*0201 allele-specific human mAb whereas HMP12 secretes a human mAb recognizing the DRB1*1101, 1102, 1103, and 1104...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(92)90008-b
更新日期：1992-12-01 00:00:00
abstract：:Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90128-n
更新日期：1993-04-01 00:00:00
abstract：:HLA-G molecules seem to have a protective effect for the semi-allogeneic fetus by mother immunosuppression. Also, pregnancy pathologies have been associated to HLA-G(∗)01:05N "null allele". In addition, other general regulatory immune functions have been associated to HLA-G in infections, tumors and autoimmunity. Thus...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2012.12.013
更新日期：2013-04-01 00:00:00
abstract：:Induction of donor type chimerism in mildly prepared hosts without graft-versus-host disease (GvHD) is a most desirable goal in bone morrow transplantation. We have recently demonstrated in a mouse model that donor veto cytotoxic T lymphocytes (CTLs) can facilitate the induction of donor type chimerism in sublethally ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.03.004
更新日期：2005-06-01 00:00:00
abstract：:We have investigated if recombinant granulocyte-macrophage colony stimulating factor (GM-CSF), alone or in concert with recombinant gamma interferon, affects the endothelial cell expression of class I major histocompatibility complex antigen. Results obtained show that the GM-CSF increases class I expression on the en...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90016-i
更新日期：1990-06-01 00:00:00
abstract：:The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cells. Recent studies ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2015.03.010
更新日期：2015-05-01 00:00:00
abstract：:Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate ge...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.03.017
更新日期：2011-07-01 00:00:00
abstract：:The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.05.001
更新日期：2017-01-01 00:00:00
abstract：:HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.02.038
更新日期：2006-04-01 00:00:00
abstract：:We followed 138 Spanish patients (37 men and 101 women) with rheumatoid arthritis (RA) to analyze whether patient sex influenced the HLA-DRB1 associations with disease susceptibility. Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specifi...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00119-6
更新日期：1999-12-01 00:00:00
abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00124-9
更新日期：1995-05-01 00:00:00
abstract：:Monoclonal antibodies (DA-2 and CA-2) and xenoantisera (rabbit anti-human, p23,30) specific for HLA-DR framework determinants were added to primary and secondary mixed lymphocyte cultures. Although such antisera were shown to inhibit primary MLC, primed lymphocytes were much less sensitive to the blocking effects of t...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(81)90050-1
更新日期：1981-10-01 00:00:00
abstract：:This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2008.07.018
更新日期：2008-11-01 00:00:00
abstract：:rs151290 in KCNQ1 and rs972283 in KLF14 have been evaluated in terms of risk of type 2 diabetes mellitus (T2DM), but the results are inconsistent. We performed an meta-analysis to assess the contributions of rs151290 in KCNQ1 and rs972283 in KLF14 to risk of T2DM. We searched the worldwide literature published from 20...
journal_title：Human immunology
pub_type： 杂志文章,meta分析
doi：10.1016/j.humimm.2014.01.008
更新日期：2014-04-01 00:00:00
abstract：:Development of tolerance protocols requires assays or biomarkers that distinguish tolerant recipients from non-tolerant ones to be established. In addition, a thorough understanding of the plausible mechanisms associated with clinical transplant tolerance is necessary to take the field forward. Unlike the majority of ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2018.01.009
更新日期：2018-05-01 00:00:00
abstract：:Conventional matching is based on numbers of alleles shared between donor and recipient. This approach, however, ignores the degree of relationship between alleles and haplotypes, and therefore the actual degree of difference. To address this problem, we have compared family members using a block matching technique wh...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(97)00231-0
更新日期：1998-01-01 00:00:00
abstract：:The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wil...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(95)00047-8
更新日期：1995-10-01 00:00:00
abstract：:To elucidate the residues important for the binding of peptides to HLA-Cw3, a substitutional analysis of two HLA-Cw*0304-binding peptides was performed. The optimal registry and length for a Cw3-restricted epitope from HIV-1 p24gag was determined to be a nonamer, p24gag 144-152. Substituted analogs of this nonamer pep...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00053-6
更新日期：1998-08-01 00:00:00
abstract：:Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.12.008
更新日期：2007-03-01 00:00:00
abstract：:This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.04.007
更新日期：2010-07-01 00:00:00
abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(89)90046-3
更新日期：1989-01-01 00:00:00
abstract：:Alloantigen specific CD8+CD28- T suppressor (TS) cells differ from naturally occurring CD4+CD25+ T-regulatory (natural TR) cells not only by their phenotype but also by their mechanism of action. Natural TR have been extensively studied, leading to the identification of characteristic "molecular markers" such as Forkh...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2004.09.004
更新日期：2004-11-01 00:00:00
abstract：:Besides central tolerance peripheral tolerance is an important mechanism to avoid development of autoimmunity. Naturally occurring thymic-derived regulatory T cells (nTreg) mediate peripheral tolerance by suppressing autoreactive T cells clones having escaped thymic deletional control. This implies that nTreg have the...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2015.06.015
更新日期：2015-08-01 00:00:00
abstract：:TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00361-5
更新日期：2002-01-01 00:00:00
abstract：:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.11.014
更新日期：2010-02-01 00:00:00
