当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Influence on antibody recognition of amino acid substitutions in the cleft of HLA-DQ2 molecules. Suggestive evidence of peptide-dependent epitopes.

Influence on antibody recognition of amino acid substitutions in the cleft of HLA-DQ2 molecules. Suggestive evidence of peptide-dependent epitopes.

Abstract：

:The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wild-type or mutated DQ beta 1 *0202. Several aa substitutions were found to influence the binding of DQ2 mAbs. All but one of the mAbs were clearly sensitive to the introduced aa substitutions, but individual mAbs were differentially influenced, suggesting that they recognized different epitopes on the DQ2 molecule. Substitutions in positions 30 and 37 of the peptide-binding cleft were also found to influence the binding of some mAbs. Second, two mAbs, NFLD.M71 and NFLD.M102, which bound to DQ(alpha 1*0501, beta 1*0202) expressed in human cells and were sensitive to the introduction of aa substitutions in the cleft, bound weakly to the DQ(alpha 1*0501, beta 1*0202) heterodimer when expressed in a transfected murine NIH 3T3 cell line. Together this indicates that some DQ2-reactive mAbs may recognize peptide-dependent epitopes.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Viken HD,Paulsen G,Drover S,Marshall WH,Sollid LM,Gaudernack G,Thorsby E

doi

10.1016/0198-8859(95)00047-8

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

63-9

issue

2

eissn

0198-8859

issn

1879-1166

pii

0198-8859(95)00047-8

journal_volume

44

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII.

    abstract：:The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90058-h

    authors： Klein D,Vincek V,Kasahara M,Schönbach C,O'hUigin C,Klein J

    更新日期：1991-11-01 00:00:00

  • HLA class I polymorphism: structure and function and still questions.

    abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(97)00175-4

    authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

    更新日期：1997-09-15 00:00:00

  • Human T4+ T-lymphocyte clones specific for the B fragment of tetanus toxin.

    abstract：:Two T4+ cloned T-lymphocyte lines specific for a papain digest product of tetanus toxin are functionally characterized. The two clones were obtained from peripheral blood mononuclear cells activated in vitro by tetanus toxoid, expanded with IL-2, and cloned in soft agar. Both clones could be induced to undergo blastog...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(87)90042-5

    authors： Scrivner D,Kristof S,Rodey G

    更新日期：1987-08-01 00:00:00

  • Expression of human leukocyte antigen-G in systemic lupus erythematosus.

    abstract：:The purpose of this study was to examine the expression of human leukocyte antigen-G (HLA-G) in patients with systemic lupus erythematosus (SLE) and its relation with interleukin-10 (IL-10) production. The study included 50 female SLE patients and 59 healthy female donors. HLA-G expression in peripheral blood and cuta...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.11.001

    authors： Rosado S,Perez-Chacon G,Mellor-Pita S,Sanchez-Vegazo I,Bellas-Menendez C,Citores MJ,Losada-Fernandez I,Martin-Donaire T,Rebolleda N,Perez-Aciego P

    更新日期：2008-01-01 00:00:00

  • HLA-G regulatory haplotypes and implantation outcome in couples who underwent assisted reproduction treatment.

    abstract：:The role of HLA-G in several clinical conditions related to reproduction has been investigated. Important polymorphisms have been found within the 5'URR and 3'UTR regions of the HLA-G promoter. The aim of the present study was to investigate 16 SNPs in the 5'URR and 14-bp insertion/deletion (ins/del) polymorphism loca...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.06.002

    authors： Costa CH,Gelmini GF,Wowk PF,Mattar SB,Vargas RG,Roxo VM,Schuffner A,Bicalho Mda G

    更新日期：2012-09-01 00:00:00

  • Lack of shared lymphocyte-stimulating determinants between H-2I and HLA-D/DR using mouse primed lymphocyte typing cells.

    abstract：:A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We hav...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(83)80011-1

    authors： Shaut DM,Ireland J,Scornik JC,Peck AB

    更新日期：1983-06-01 00:00:00

  • Partial activation of human T cells by peptide analogs on live APC: induction of clonal anergy associated with protein tyrosine dephosphorylation.

    abstract：:T-cell clonal anergy induced by peptide analogs in the presence of live APC in murine systems was reported to be associated with incomplete tyrosine phosphorylation of the CD3 zeta chain followed by a lack of subsequent ZAP-70 recruitment. Furthermore, protein tyrosine phosphatase SHP-1 was associated with ZAP-70 upon...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/S0198-8859(96)00273-X

    authors： Matsushita S,Nishimura Y

    更新日期：1997-03-01 00:00:00

  • Elevated pretransplantation soluble CD30 is associated with decreased early allograft function after human lung transplantation.

    abstract：:Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2008.12.005

    authors： Shah AS,Leffell MS,Lucas D,Zachary AA

    更新日期：2009-02-01 00:00:00

  • Conversion of a human immunodeficiency virus cytotoxic T lymphocyte epitope into a high affinity HLA-Cw3 ligand.

    abstract：:To elucidate the residues important for the binding of peptides to HLA-Cw3, a substitutional analysis of two HLA-Cw*0304-binding peptides was performed. The optimal registry and length for a Cw3-restricted epitope from HIV-1 p24gag was determined to be a nonamer, p24gag 144-152. Substituted analogs of this nonamer pep...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00053-6

    authors： Zarling AL,Lee DR

    更新日期：1998-08-01 00:00:00

  • TLR expression, phagocytosis and oxidative burst in healthy and septic newborns in response to Gram-negative and Gram-positive rods.

    abstract：:The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.07.230

    authors： Silveira-Lessa AL,Quinello C,Lima L,Redondo ACC,Ceccon MEJR,Carneiro-Sampaio M,Palmeira P

    更新日期：2016-10-01 00:00:00

  • CD28 gene polymorphisms and acute cellular rejection after liver transplantation.

    abstract：:The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective case- control study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associa...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.10.002

    authors： Thude H,Tiede P,Sterneck M,Peine S,Nashan B,Koch M

    更新日期：2020-12-01 00:00:00

  • Transnational validation of the Australian algorithm for virtual crossmatch allocation in kidney paired donation.

    abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.01.029

    authors： Böhmig GA,Fidler S,Christiansen FT,Fischer G,Ferrari P

    更新日期：2013-05-01 00:00:00

  • Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population.

    abstract：:Polymorphisms of interleukin-23 receptor (IL23R) gene have recently been reported to be associated with the susceptibility to several immune-related diseases. The aim of this study was to determine the association of IL23R polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome, a disease presumably mediated by autoimm...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.01.026

    authors： Jiang Z,Yang P,Hou S,Li F,Zhou H

    更新日期：2010-04-01 00:00:00

  • Limited impact of pre-existing donor specific HLA-antibodies (DSA) on long term allograft survival after first adult liver transplantation.

    abstract：:The relevance of pre-existing HLA-antibodies (HLA-Ab) in liver transplantation (LTx) is controversial. While livers are allocated without HLA match or preoperative crossmatch testing, several studies point to an impact of donor specific antibodies (DSA) for acute rejection, bile duct complications or even graft loss. ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.04.009

    authors： Koch M,Marget M,Sterneck M,Fischer L,Thude H,Nashan B

    更新日期：2018-07-01 00:00:00

  • Association analysis of class II cytokine and receptor genes in vitiligo patients.

    abstract：:The loss of melanocytes in vitiligo is mainly attributed to defective autoimmune mechanisms and lately autoinflammatory mediators have become more emphasized. Among these, a number of class II cytokines and their receptors have displayed altered expression patterns in vitiligo. Thus, we selected 30 SNPs from the regio...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2015.09.050

    authors： Traks T,Karelson M,Reimann E,Rätsep R,Silm H,Vasar E,Kõks S,Kingo K

    更新日期：2016-05-01 00:00:00

  • Cd4(+) T cell response to Leishmania spp. in non-infected individuals.

    abstract：:T cell mediated immunity is known to play a central role in the host response to control intra-cellular pathogens. This work demonstrates the presence of specific CD4(+) T cells to Leishmania spp. antigens in peripheral mononuclear cells of naïve individuals (normal volunteers from non-endemic regions). The responder ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00119-1

    authors： Gabaglia CR,Valle MT,Fenoglio D,Barcinski MA,Manca F

    更新日期：2000-06-01 00:00:00

  • Cytofluorometric analysis of major histocompatibility antigens on human monocytes using monoclonal antibodies.

    abstract：:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(83)90069-1

    authors： Nunez G,Stastny P

    更新日期：1983-01-01 00:00:00

  • Characterization of skin-infiltrating T lymphocytes during acute graft-versus-host disease.

    abstract：:A panel of 34 clones was established from a cell line derived from the skin biopsy of a patient (genotype: A1, A2, B7, B8, DR3, DR6) undergoing acute graft-versus-host disease after semiallogeneic bone marrow transplantation with his mother's bone marrow (genotype: A1, A1, B7, B8, DR3, DR6). The T-cell line obtained p...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90074-y

    authors： Vié HP,Millpied N,Devilder MC,Mahe B,Hallet MM,Moreau JF,Soulillou JP

    更新日期：1990-10-01 00:00:00

  • Activation of TLR2 and TLR4 by minimally modified low-density lipoprotein in human macrophages and monocytes triggers the inflammatory response.

    abstract：:Oxidized low-density lipoproteins and Toll-like receptors (TLR) 2 and 4 are involved in the development of atherosclerosis. The TLR are important in the pro-inflammatory response. The aim of this research was to analyze the activation of CD14, TLR4, and TLR2 in response to minimally modified low-density lipoprotein (m...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.05.005

    authors： Chávez-Sánchez L,Madrid-Miller A,Chávez-Rueda K,Legorreta-Haquet MV,Tesoro-Cruz E,Blanco-Favela F

    更新日期：2010-08-01 00:00:00

  • gamma-aminobutyric acid-transaminase activity in the human thymus after administration of interferons.

    abstract：:The purpose of this article is to study the amounts of gamma-aminobutyric acid-transaminase (GABA-t) during immune response in the human thymus. GABA-t was studied by biochemical and histochemical methods in 7 immunostimulated (treated) and 7 non-immunostimulated (untreated) patients (4 young adult, age range: 24-36 y...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00130-0

    authors： Cavallotti D,Artico M,D'Andrea V,Cavallotti C

    更新日期：2000-07-01 00:00:00

  • Mitogen-induced modulation of CD3, CD4, and CD8(1).

    abstract：:It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00128-7

    authors： Jason J,Inge KL

    更新日期：2000-03-01 00:00:00

  • Concomitant augmentation of type 1 CD4+ and CD8+ T-cell responses during successful interferon-alpha and ribavirin treatment for chronic hepatitis C virus infection.

    abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(03)00041-7

    authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

    更新日期：2003-05-01 00:00:00

  • HLA-A11-mediated protection from NK cell-mediated lysis: role of HLA-A11-presented peptides.

    abstract：:The capacity of MHC class I to protect target cells from NK is well established, but the mechanism by which these molecules influence NK recognition and the physical properties associated with this function remain poorly defined. We have examined this issue using as a model the HLA-A11 allele. HLA-A11 expression corre...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(96)00031-6

    authors： Gavioli R,Zhang QJ,Masucci MG

    更新日期：1996-08-01 00:00:00

  • Interleukin 10 gene single nucleotide polymorphisms in Polish patients with chronic hepatitis C: Analysis of association with severity of disease and treatment outcome.

    abstract：:It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nuc...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.10.015

    authors： Świątek-Kościelna B,Kałużna E,Strauss E,Januszkiewicz-Lewandowska D,Bereszyńska I,Wysocki J,Rembowska J,Barcińska D,Antosik D,Mozer-Lisewska I,Nowak J

    更新日期：2017-02-01 00:00:00

  • MICA A8: a new allele within MHC class I chain-related A transmembrane region with eight GCT repeats.

    abstract：:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.10.007

    authors： Gambelunghe G,Brozzetti AL,Ghaderi M,Tortoioli C,Falorni A

    更新日期：2006-12-01 00:00:00

  • HLA-G haplotype structure shows good conservation between different populations and good correlation with high, normal and low soluble HLA-G expression.

    abstract：:HLA-G molecule has considerable impact in various clinical fields, therefore many studies attempted to predict its expression based on HLA-G genotype. These studies have focused on polymorphisms in either the coding region or in one of the two untranslated regions (UTR) of the gene. The aim of our study was to determi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.10.027

    authors： Di Cristofaro J,El Moujally D,Agnel A,Mazières S,Cortey M,Basire A,Chiaroni J,Picard C

    更新日期：2013-02-01 00:00:00

  • Association of IL10 promoter polymorphisms with idiopathic achalasia.

    abstract：:Idiopathic achalasia is an esophageal motor disorder of unknown etiology. A wealth of evidence supports the concept that achalasia is an immune-mediated disease. According to this evidence, achalasia has been significantly associated with specific alleles of the human leukocyte antigen class II, PTPN22 and IL23R. Seve...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.05.017

    authors： Nuñez C,García-González MA,Santiago JL,Benito MS,Mearín F,de la Concha EG,de la Serna JP,de León AR,Urcelay E,Vigo AG

    更新日期：2011-09-01 00:00:00

  • Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes.

    abstract：:Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.04.011

    authors： Lee N,Shin MS,Kang Y,Park K,Maeda T,Nishioka H,Fujii H,Kang I

    更新日期：2016-06-01 00:00:00

  • Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.

    abstract：:Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.12.008

    authors： Tassiulas I,Park-Min KH,Hu Y,Kellerman L,Mevorach D,Ivashkiv LB

    更新日期：2007-03-01 00:00:00

  • Human cell lines express multiple populations of Ia-like molecules.

    abstract：:Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(81)90044-6

    authors： Pesando JM,Nadler LM,Lazarus H,Tomaselli KJ,Stashenko P,Ritz J,Levine H,Yunis EJ,Schlossman SF

    更新日期：1981-08-01 00:00:00